Fibrin(ogen) in human disease: both friend and foe

• Published in: Haematologica (Roma) Vol. 105; no. 2; pp. 284 - 296
• Main Authors: Vilar, Rui, Fish, Richard J., Casini, Alessandro, Neerman-Arbez, Marguerite
• Format: Journal Article
• Language: English
• Published: Italy Ferrata Storti Foundation 01.02.2020
• Subjects: Fibrin; Fibrinogen; Humans; Review; Thrombin

Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 days. With fibrin, produced by thrombin-mediated cleavage, fibrinogen plays important roles in many physiological p...