Transcriptomic profiles reveal differences in zinc metabolism, inflammation, and tight junction proteins in duodenum from cholesterol gallstone subjects

• Published in: Scientific reports Vol. 10; no. 1; p. 7448
• Main Authors: Riveras, Eleodoro, Azocar, Lorena, Moyano, Tomas C., Ocares, Marcia, Molina, Hector, Romero, Diego, Roa, Juan C., Valbuena, Jose R., Gutiérrez, Rodrigo A., Miquel, Juan F.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.05.2020; Nature Publishing Group
• Subjects: 631/337/2019; 692/308/2056; 692/4020/1503/1328/1498/1376; Adult; Biopsy; Calculi; Cholelithiasis - diagnostic imaging; Cholelithiasis - metabolism; Cholelithiasis - pathology; Cholesterol; Cholesterol - metabolism; Crystallization; Duodenum; Duodenum - metabolism; Female; Gallbladder; Gallstones; Gene expression; Gene Expression Regulation; Humanities and Social Sciences; Humans; Immunofluorescence; Immunohistochemistry; Inflammation - metabolism; Male; Membrane Transport Proteins - metabolism; Metallothionein; Metallothionein - metabolism; Microbiota; Molecular modelling; multidisciplinary; Pathogenesis; Prevalence; Risk Factors; RNA-Seq; Science; Science (multidisciplinary); Small intestine; Supplements; Tight Junction Proteins - metabolism; Tight Junctions - metabolism; Transcription; Transcriptome; Ultrasonography; Young Adult; Zinc; Zinc - metabolism

Cholesterol Gallstone Disease (GSD) is a common multifactorial disorder characterized by crystallization and aggregation of biliary cholesterol in the gallbladder. The global prevalence of GSD is ~10–20% in the adult population but rises to 28% in Chile (17% among men and 30% among women). The small...