The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality

• Published in: Haematologica (Roma) Vol. 106; no. 11; pp. 2971 - 2985
• Main Authors: Issaian, Aaron, Hay, Ariel, Dzieciatkowska, Monika, Roberti, Domenico, Perrotta, Silverio, Darula, Zsuzsanna, Redzic, Jasmina, Busch, Micheal P., Page, Grier P., Rogers, Stephen C., Doctor, Allan, Hansen, Kirk C., Eisenmesser, Elan Z., Zimring, James C., D’Alessandro, Angelo
• Format: Journal Article
• Language: English
• Published: Italy Fondazione Ferrata Storti 01.11.2021; Ferrata Storti Foundation
• Subjects: Animals; Anion Exchange Protein 1, Erythrocyte - chemistry; Blood Banks; Erythrocytes - metabolism; Hemolysis; Humans; Mice; Oxidation-Reduction; Pentose Phosphate Pathway

Band 3 (anion exchanger 1; AE1) is the most abundant membrane protein in red blood cells, which in turn are the most abundant cells in the human body. A compelling model posits that, at high oxygen saturation, the N-terminal cytosolic domain of AE1 binds to and inhibits glycolytic enzymes, thus dive...