Prioritization of causal genes for coronary artery disease based on cumulative evidence from experimental and in silico studies

• Published in: Scientific reports Vol. 10; no. 1; p. 10486
• Main Authors: Shadrina, Alexandra S., Shashkova, Tatiana I., Torgasheva, Anna A., Sharapov, Sodbo Z., Klarić, Lucija, Pakhomov, Eugene D., Alexeev, Dmitry G., Wilson, James F., Tsepilov, Yakov A., Joshi, Peter K., Aulchenko, Yurii S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.06.2020; Nature Publishing Group
• Subjects: 631/208/2489/144; 692/699/75/593/15; Cardiovascular disease; Computer Simulation; Coronary artery; Coronary Artery Disease - genetics; Coronary vessels; Etiology; Gene expression; Gene loci; Genetic Predisposition to Disease - genetics; Genome-wide association studies; Genome-Wide Association Study - methods; Genomes; Genomics - methods; Heart diseases; Humanities and Social Sciences; Humans; multidisciplinary; Polymorphism, Single Nucleotide - genetics; Quantitative Trait Loci - genetics; Risk Factors; Science; Science (multidisciplinary)

Genome-wide association studies have led to a significant progress in identification of genomic loci affecting coronary artery disease (CAD) risk. However, revealing the causal genes responsible for the observed associations is challenging. In the present study, we aimed to prioritize CAD-relevant g...