Disrupted social memory ensembles in the ventral hippocampus underlie social amnesia in autism-associated Shank3 mutant mice

• Published in: Molecular psychiatry Vol. 27; no. 4; pp. 2095 - 2105
• Main Authors: Tao, Kentaro, Chung, Myung, Watarai, Akiyuki, Huang, Ziyan, Wang, Mu-Yun, Okuyama, Teruhiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2022; Nature Publishing Group
• Subjects: 631/378; 64/60; 692/699/476/1373; 9/30; Amnesia; Animals; Autism; Autistic Disorder; Behavioral Sciences; Biological Psychology; Cognitive ability; Conspecifics; Firing pattern; Hippocampus; Hippocampus - physiology; Medicine; Medicine & Public Health; Memory; Mice; Microfilament Proteins; Nerve Tissue Proteins; Neurons; Neurons - physiology; Neurosciences; Pharmacotherapy; Psychiatry; Social behavior; Social interactions; Theta rhythms

The ability to remember conspecifics is critical for adaptive cognitive functioning and social communication, and impairments of this ability are hallmarks of autism spectrum disorders (ASDs). Although hippocampal ventral CA1 (vCA1) neurons are known to store social memories, how their activities ar...