A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells

• Published in: Scientific reports Vol. 7; no. 1; pp. 9873 - 13
• Main Authors: Zhang, Saiyang, Li, Tingyu, Zhang, Li, Wang, Xiangyu, Dong, Hangqi, Li, Lili, Fu, Dongjun, Li, Yongchun, Zi, Xiaolin, Liu, Hong-Min, Zhang, Yanbing, Xu, Hongde, Jin, Cheng-Yun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.08.2017; Nature Publishing Group
• Subjects: 13/1; 13/109; 13/2; 13/31; 13/51; 14/1; 14/19; 14/34; 14/35; 631/67/1059/153; 631/80/82/23; 96/1; 96/2; Acetylcysteine; Apoptosis; Bcl-2 protein; Caspase; Caspase-9; Cytotoxicity; Epithelial cells; Gastric cancer; Humanities and Social Sciences; multidisciplinary; Rodents; Science; Science (multidisciplinary); Toxicity; Tumor cell lines; Xenografts

A new series of etherification chalcone derivatives were designed and synthesized through Willimison etherification and Claisen-Schmidt condensation. Among them, compound 2-c which was given chemical name of S17 , has been successfully screened out as the most potent one on gastric cancer cell line(...