Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses
Systems vaccinology has defined molecular signatures and mechanisms of immunity to vaccination. However, comparative analysis of immunity to different vaccines is lacking. We integrated transcriptional data of over 3,000 samples, from 820 adults across 28 studies of 13 vaccines and analyzed vaccinat...
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Published in | Nature immunology Vol. 23; no. 12; pp. 1788 - 1798 |
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Main Authors | , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Nature Publishing Group US
01.12.2022
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | Systems vaccinology has defined molecular signatures and mechanisms of immunity to vaccination. However, comparative analysis of immunity to different vaccines is lacking. We integrated transcriptional data of over 3,000 samples, from 820 adults across 28 studies of 13 vaccines and analyzed vaccination-induced signatures of antibody responses. Most vaccines induced signatures of innate immunity and plasmablasts at days 1 and 7, respectively, after vaccination. However, the yellow fever vaccine induced an early transient signature of T and B cell activation at day 1, followed by delayed antiviral/interferon and plasmablast signatures that peaked at days 7 and 14–21, respectively. Thus, there was no evidence for a ‘universal signature’ that predicted antibody response to all vaccines. However, accounting for the asynchronous nature of responses, we defined a time-adjusted signature that predicted antibody responses across vaccines. These results provide a transcriptional atlas of immunity to vaccination and define a common, time-adjusted signature of antibody responses.
Pulendran and colleagues perform a comparative analysis of transcriptional responses of healthy young adults across 13 different vaccines. They find that while a common transcriptional program is shared across many vaccines, there is significant heterogeneity especially in the kinetics of immune responses. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conception or design of the work: BP, SHK. Analysis: TH, BG, LET, AL. Acquisition: EH, HERM, JDA, PD, HIPC, OL, RG, MMS, JST, MSF, SF, MPM, DGC, DR. Interpretation of the data and manuscript writing: TH, BP, SHK, RPS. These authors jointly supervised this work List of authors and their affiliations appear at the end of the paper. Author Contributions |
ISSN: | 1529-2908 1529-2916 1529-2916 |
DOI: | 10.1038/s41590-022-01328-6 |