Trimethylamine N-Oxide, Circulating Endothelial Progenitor Cells, and Endothelial Function in Patients with Stable Angina

• Published in: Scientific reports Vol. 9; no. 1; p. 4249
• Main Authors: Chou, Ruey-Hsing, Chen, Chi-Yu, Chen, I-Chun, Huang, Hsin-Lei, Lu, Ya-Wen, Kuo, Chin-Sung, Chang, Chun-Chin, Huang, Po-Hsun, Chen, Jaw-Wen, Lin, Shing-Jong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.03.2019; Nature Publishing Group
• Subjects: 13/31; 631/45/127; 692/4019/592/75/593/2100; 82/51; Aged; Angina; Angina pectoris; Angina, Stable - blood; Angina, Stable - diagnosis; Angina, Stable - immunology; Angina, Stable - physiopathology; Angiography; Arteriosclerosis; Atherosclerosis; C-Reactive Protein - analysis; C-Reactive Protein - immunology; Choline; Coronary Angiography; Endothelial Progenitor Cells - metabolism; Endothelium, Vascular - physiopathology; Female; Humanities and Social Sciences; Humans; IL-1β; Inflammation; Male; Metabolites; Methylamines - blood; Methylamines - metabolism; Middle Aged; multidisciplinary; Oxidants - blood; Oxidants - metabolism; Oxidative stress; Progenitor cells; Retrospective Studies; Science; Science (multidisciplinary); Stem cells; Toxicity; Trimethylamine; Vasodilation; Vasodilation - physiology

Trimethylamine N-oxide (TMAO) is a metabolite originated from bacterial metabolism of choline-rich foods. Evidence suggests an association between TMAO and atherosclerosis, but the relationship between TMAO and endothelial progenitor cells (EPCs) remains unclear. This study aimed to identify the rel...