Silk fibroin nanocomposites as tissue engineering scaffolds – A systematic review

Silk fibroin is a protein with intrinsic characteristics that make it a good candidate as a scaffold for tissue engineering. Recent works have enhanced its benefits by adding inorganic phases that interact with silk fibroin in different ways. A systematic review was performed in four databases to st...

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Published inBiomedicine & pharmacotherapy Vol. 141; p. 111924
Main Authors Zuluaga-Vélez, Augusto, Quintero-Martinez, Adrián, Orozco, Lina M., Sepúlveda-Arias, Juan C.
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.09.2021
Elsevier
Subjects
Animals
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - chemical synthesis
Biocompatible Materials - administration & dosage
Biocompatible Materials - chemical synthesis
Cell Proliferation - drug effects
Cell Proliferation - physiology
Fibroins - administration & dosage
Fibroins - chemical synthesis
Humans
Immunologic Factors - administration & dosage
Immunologic Factors - chemical synthesis
Nanocomposite
Nanocomposites - administration & dosage
Nanocomposites - chemistry
Neovascularization, Physiologic - drug effects
Neovascularization, Physiologic - physiology
Regenerative medicine
Silk fibroin
Tissue engineering
Tissue Engineering - methods
Tissue scaffold
Tissue Scaffolds - chemistry
Tissue scaffold
Silk fibroin
Nanocomposite
Tissue engineering
Regenerative medicine
Online AccessGet full text

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Abstract Silk fibroin is a protein with intrinsic characteristics that make it a good candidate as a scaffold for tissue engineering. Recent works have enhanced its benefits by adding inorganic phases that interact with silk fibroin in different ways. A systematic review was performed in four databases to study the physicochemical and biological performance of silk fibroin nanocomposites. In the last decade, only 51 articles contained either in vitro cell culture models or in vivo tests. The analysis of such works resulted in their classification into the following scaffold types: particles, mats and textiles, films, hydrogels, sponge-like structures, and mixed conformations. From the physicochemical perspective, the inorganic phase imbued in silk fibroin nanocomposites resulted in better stability and mechanical performance. This review revealed that the inorganic phase may be associated with specific biological responses, such as neovascularisation, cell differentiation, cell proliferation, and antimicrobial and immunomodulatory activity. The study of nanocomposites as tissue engineering scaffolds is a highly active area mostly focused on bone and cartilage regeneration with promising results. Nonetheless, there are still many challenges related to their application in other tissues, a better understanding of the interaction between the inorganic and organic phases, and the associated biological response. [Display omitted] •A systematic review on the use of silk fibroin nanocomposites as tissue engineering scaffolds was carried out.•A total of 51 studies were included after exclusion criteria.•The inorganic phase in silk fibroin nanocomposites resulted in better physicochemical stability and biological responses.•Silk fibroin nanocomposites have enormous potential as scaffolds for tissue engineering.
AbstractList Silk fibroin is a protein with intrinsic characteristics that make it a good candidate as a scaffold for tissue engineering. Recent works have enhanced its benefits by adding inorganic phases that interact with silk fibroin in different ways. A systematic review was performed in four databases to study the physicochemical and biological performance of silk fibroin nanocomposites. In the last decade, only 51 articles contained either in vitro cell culture models or in vivo tests. The analysis of such works resulted in their classification into the following scaffold types: particles, mats and textiles, films, hydrogels, sponge-like structures, and mixed conformations. From the physicochemical perspective, the inorganic phase imbued in silk fibroin nanocomposites resulted in better stability and mechanical performance. This review revealed that the inorganic phase may be associated with specific biological responses, such as neovascularisation, cell differentiation, cell proliferation, and antimicrobial and immunomodulatory activity. The study of nanocomposites as tissue engineering scaffolds is a highly active area mostly focused on bone and cartilage regeneration with promising results. Nonetheless, there are still many challenges related to their application in other tissues, a better understanding of the interaction between the inorganic and organic phases, and the associated biological response.
Silk fibroin is a protein with intrinsic characteristics that make it a good candidate as a scaffold for tissue engineering. Recent works have enhanced its benefits by adding inorganic phases that interact with silk fibroin in different ways. A systematic review was performed in four databases to study the physicochemical and biological performance of silk fibroin nanocomposites. In the last decade, only 51 articles contained either in vitro cell culture models or in vivo tests. The analysis of such works resulted in their classification into the following scaffold types: particles, mats and textiles, films, hydrogels, sponge-like structures, and mixed conformations. From the physicochemical perspective, the inorganic phase imbued in silk fibroin nanocomposites resulted in better stability and mechanical performance. This review revealed that the inorganic phase may be associated with specific biological responses, such as neovascularisation, cell differentiation, cell proliferation, and antimicrobial and immunomodulatory activity. The study of nanocomposites as tissue engineering scaffolds is a highly active area mostly focused on bone and cartilage regeneration with promising results. Nonetheless, there are still many challenges related to their application in other tissues, a better understanding of the interaction between the inorganic and organic phases, and the associated biological response. [Display omitted] •A systematic review on the use of silk fibroin nanocomposites as tissue engineering scaffolds was carried out.•A total of 51 studies were included after exclusion criteria.•The inorganic phase in silk fibroin nanocomposites resulted in better physicochemical stability and biological responses.•Silk fibroin nanocomposites have enormous potential as scaffolds for tissue engineering.
ArticleNumber 111924
Author Sepúlveda-Arias, Juan C.
Zuluaga-Vélez, Augusto
Quintero-Martinez, Adrián
Orozco, Lina M.
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  givenname: Adrián
  surname: Quintero-Martinez
  fullname: Quintero-Martinez, Adrián
  organization: Grupo Infección e Inmunidad, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira, Pereira, Colombia
– sequence: 3
  givenname: Lina M.
  surname: Orozco
  fullname: Orozco, Lina M.
  organization: Grupo Infección e Inmunidad, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira, Pereira, Colombia
– sequence: 4
  givenname: Juan C.
  surname: Sepúlveda-Arias
  fullname: Sepúlveda-Arias, Juan C.
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  organization: Grupo Infección e Inmunidad, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira, Pereira, Colombia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34328093$$D View this record in MEDLINE/PubMed
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Keywords Tissue scaffold
Silk fibroin
Nanocomposite
Tissue engineering
Regenerative medicine
Language English
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Snippet Silk fibroin is a protein with intrinsic characteristics that make it a good candidate as a scaffold for tissue engineering. Recent works have enhanced its...
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SubjectTerms Animals
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - chemical synthesis
Biocompatible Materials - administration & dosage
Biocompatible Materials - chemical synthesis
Cell Proliferation - drug effects
Cell Proliferation - physiology
Fibroins - administration & dosage
Fibroins - chemical synthesis
Humans
Immunologic Factors - administration & dosage
Immunologic Factors - chemical synthesis
Nanocomposite
Nanocomposites - administration & dosage
Nanocomposites - chemistry
Neovascularization, Physiologic - drug effects
Neovascularization, Physiologic - physiology
Regenerative medicine
Silk fibroin
Tissue engineering
Tissue Engineering - methods
Tissue scaffold
Tissue Scaffolds - chemistry
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Title Silk fibroin nanocomposites as tissue engineering scaffolds – A systematic review
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