TRIM5α: A Protean Architect of Viral Recognition and Innate Immunity

• Published in: Viruses Vol. 16; no. 7; p. 997
• Main Authors: Spada, Stephanie J., Grigg, Michael E., Bouamr, Fadila, Best, Sonja M., Zhang, Peijun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.07.2024
• Subjects: Analysis; Animals; Antiviral activity; Antiviral agents; Antiviral drugs; antiviral properties; Antiviral Restriction Factors - metabolism; Autophagy; capsid; Capsids; Cellular proteins; Cytokines; Disease transmission; domain; Evolution, Molecular; Genes; Genetic diversity; Genomes; Health aspects; HIV; Host-Pathogen Interactions - immunology; Human immunodeficiency virus; Humans; Immune system; Immunity, Innate; Innate immunity; Kinases; Lentivirus; Molecular dynamics; Monkeys & apes; orthoflaviviruses; orthopoxviruses; Pathogens; Phylogeny; plasticity; Positive selection; Protein arrays; Proteins; Retroviridae - genetics; Retroviridae - immunology; Retroviridae - physiology; retroviruses; structure; TRIM5α; Tripartite Motif Proteins - metabolism; Ubiquitin-Protein Ligases - metabolism; Viral infections; Viruses; United States; TRIM5α; innate immunity; orthopoxviruses; orthoflaviviruses; structure; retroviruses

The evolutionary pressures exerted by viral infections have led to the development of various cellular proteins with potent antiviral activities, some of which are known as antiviral restriction factors. TRIpartite Motif-containing protein 5 alpha (TRIM5α) is a well-studied restriction factor of ret...