Protective role of curcumin on aflatoxin B1-induced TLR4/RIPK pathway mediated-necroptosis and inflammation in chicken liver

• Published in: Ecotoxicology and environmental safety Vol. 233; p. 113319
• Main Authors: Li, Sihong, Liu, Ruimeng, Xia, Shun, Wei, Gaoqiang, Ishfaq, Muhammad, Zhang, Yixin, Zhang, Xiuying
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.03.2022; Elsevier
• Subjects: Aflatoxin B1; Aflatoxin B1 - toxicity; Animals; Chickens - metabolism; Curcumin; Curcumin - pharmacology; Inflammation - chemically induced; Inflammation - metabolism; Liver; Necroptosis; TLR4/RIPK pathway; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - metabolism; Aflatoxin B1; Curcumin; TLR4/RIPK pathway; Necroptosis; Liver

This study set out to assess the mitigative effects of curcumin on AFB1-induced necroptosis and inflammation in chicken liver. Ninety-six one-day-old AA broiler chickens were separated into four groups, including control group, AFB1 (1 mg/kg) group, curcumin (300 mg/kg) + AFB1 (1 mg/kg) group and cu...