Loss of CD14 leads to disturbed epithelial-B cell crosstalk and impairment of the intestinal barrier after E. coli Nissle monoassociation
The TLR4 co-receptor CD14 was identified as an IBD candidate gene. Here, its influence on the intestinal barrier was addressed utilizing E. coli Nissle (EcN), which induces severe inflammation in germfree TLR4 −/− mice. After monoassociation, EcN was detected in spleens and livers of TLR4 −/− and CD...
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Published in | Scientific reports Vol. 8; no. 1; pp. 719 - 14 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
15.01.2018
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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