Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice

• Published in: Cell death and differentiation Vol. 28; no. 5; pp. 1466 - 1476
• Main Authors: Alvarez-Diaz, Silvia, Preaudet, Adele, Samson, Andre L., Nguyen, Paul M., Fung, Ka Yee, Garnham, Alexandra L., Alexander, Warren S., Strasser, Andreas, Ernst, Matthias, Putoczki, Tracy L., Murphy, James M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2021; Nature Publishing Group
• Subjects: 13/51; 631/250/256/2516; 631/67/70; 64/60; 82; 96/63; Animal models; Animals; Apoptosis; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Analysis; Cell death; Colitis; Colon cancer; Colonic Neoplasms - genetics; Colorectal cancer; Colorectal carcinoma; Dextran; Disease Models, Animal; Gastrointestinal tract; Inflammation; Inflammation - genetics; Inflammatory bowel disease; Inflammatory bowel diseases; Large intestine; Life Sciences; Mice; Necroptosis; Necroptosis - genetics; Sodium sulfate; Stem Cells; Tumorigenesis

Chronic inflammation of the large intestine is associated with an increased risk of developing colorectal cancer (CRC), the second most common cause of cancer-related deaths worldwide. Necroptosis has emerged as a form of lytic programmed cell death that, distinct from apoptosis, triggers an inflamm...