Positive feedback regulation of lncRNA PVT1 and HIF2α contributes to clear cell renal cell carcinoma tumorigenesis and metastasis

• Published in: Oncogene Vol. 40; no. 37; pp. 5639 - 5650
• Main Authors: Zhang, Ming-xiao, Zhang, Li-zhen, Fu, Liang-min, Yao, Hao-hua, Tan, Lei, Feng, Zi-hao, Li, Jia-ying, Lu, Jun, Pan, Yi-hui, Shu, Guan-nan, Li, Peng-ju, Tang, Yi-ming, Liao, Zhuang-yao, Wei, Jin-huan, Chen, Wei, Guo, Jian-ping, Luo, Jun-hang, Chen, Zhen-hua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.09.2021; Nature Publishing Group
• Subjects: 13/51; 13/89; 14/32; 14/5; 38/77; 59/5; 631/67/322; 631/67/589/1588/1351; 64/60; 692/53/2422; 82/1; 82/29; 82/58; Angiogenesis; Apoptosis; Cell Biology; Cell migration; Cell proliferation; Clear cell-type renal cell carcinoma; Feedback; Human Genetics; Internal Medicine; Kidney cancer; Medicine; Medicine & Public Health; Metastases; Oncology; Tumorigenesis; Ubiquitination; VHL protein

Long noncoding RNAs (lncRNAs) have been reported to exert important roles in tumors, including clear cell renal cell carcinoma (ccRCC). PVT1 is an important oncogenic lncRNA which has critical effects on onset and development of various cancers, however, the underlying mechanism of PVT1 functioning...