Mesenchymal stem cells influence monocyte/macrophage phenotype: Regulatory mode and potential clinical applications

• Published in: Biomedicine & pharmacotherapy Vol. 165; p. 115042
• Main Authors: Lu, Dejin, Jiao, Xue, Jiang, Wenjian, Yang, Li, Gong, Qian, Wang, Xiaobin, Wei, Minjie, Gong, Shiqiang
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.09.2023; Elsevier
• Subjects: M1/M2 phenotype; Mesenchymal stem cells; Mitochondrial transfer; Monocytes/macrophages; Paracrine action; Phagocytosis; Mitochondrial transfer; GVHD; SLE; LPS; MSCs; IDO; NSAIDs; NLRP3; Hb; KOA; Ly6C; Mesenchymal stem cells; CCR2; PGE2; EVs; Paracrine action; PKM2; M1/M2 phenotype; RDEB; Monocytes/macrophages; MVs; PBMCs; ECM; IL-10; MPs; CXCL12; HLA-DR; TNF-α; TLR4; Phagocytosis; TNTs

Mesenchymal stem cells (MSCs) are pluripotent stem cells derived from a variety of tissues, such as umbilical cord, fat, and bone marrow. Today, MSCs are widely recognized for their prominent anti-inflammatory properties in a variety of acute and chronic inflammatory diseases. In inflammatory diseas...