Relationship between amyloid and tau levels and its impact on tau spreading

• Published in: European journal of nuclear medicine and molecular imaging Vol. 48; no. 7; pp. 2225 - 2232
• Main Authors: Doré, Vincent, Krishnadas, Natasha, Bourgeat, Pierrick, Huang, Kun, Li, Shenpeng, Burnham, Samantha, Masters, Colin L., Fripp, Jurgen, Villemagne, Victor L., Rowe, Christopher C.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2021; Springer Nature B.V
• Subjects: Alzheimer's disease; Amygdala; Cardiology; Cerebral cortex; Cortex (entorhinal); Fluorine isotopes; Imaging; Medicine; Medicine & Public Health; Neocortex; Neuroimaging; Neurology – Dementia; Nuclear Medicine; Oncology; Original; Original Article; Orthopedics; Parahippocampal gyrus; Radiology; Temporal lobe; Tau imaging; Tauopathies; Aβ-amyloid imaging; Alzheimer’s disease; Neurodegeneration; Positron emission tomography

Purpose Previous studies have shown that Aβ-amyloid (Aβ) likely promotes tau to spread beyond the medial temporal lobe. However, the Aβ levels necessary for tau to spread in the neocortex is still unclear. Methods Four hundred sixty-six participants underwent tau imaging with [18F]MK6420 and Aβ imag...