Type 1 diabetes in Africa: an immunogenetic study in the Amhara of North-West Ethiopia

• Published in: Diabetologia Vol. 63; no. 10; pp. 2158 - 2168
• Main Authors: Balcha, Shitaye A., Demisse, Abayneh G., Mishra, Rajashree, Vartak, Tanwi, Cousminer, Diana L., Hodge, Kenyaita M., Voight, Benjamin F., Lorenz, Kim, Schwartz, Stanley, Jerram, Samuel T., Gamper, Arla, Holmes, Alice, Wilson, Hannah F., Williams, Alistair J. K., Grant, Struan F. A., Leslie, R. David, Phillips, David I. W., Trimble, Elisabeth R.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2020; Springer Nature B.V
• Subjects: Adolescent; Adult; Age of Onset; Autoantibodies; Autoantibodies - immunology; Autoimmunity; Black People - genetics; C-Peptide - blood; Child; Diabetes; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Drb1 protein; Ethiopia; Female; Genome-wide association studies; Genome-Wide Association Study; Genomes; Genotyping; Glutamate decarboxylase; Heritability; Histocompatibility antigen HLA; HLA-DRB1 Chains - genetics; Human Physiology; Humans; Immunogenetics; Immunogenicity; Insulin; Internal Medicine; Major histocompatibility complex; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Peptides; Population studies; Principal Component Analysis; Principal components analysis; Single-nucleotide polymorphism; Young Adult; Zinc Transporter 8 - immunology; Ethiopia; Rural; Autoantibodies; Type 1 diabetes; Africa; Genomes; HLA; Ethiopia

Aims/hypothesis We aimed to characterise the immunogenic background of insulin-dependent diabetes in a resource-poor rural African community. The study was initiated because reports of low autoantibody prevalence and phenotypic differences from European-origin cases with type 1 diabetes have raised...