Novel and revisited approaches in nanoparticle systems for buccal drug delivery

• Published in: Journal of controlled release Vol. 320; pp. 125 - 141
• Main Authors: Macedo, Ana S., Castro, Pedro M., Roque, Luís, Thomé, Natália G., Reis, Catarina P., Pintado, Manuela E., Fonte, Pedro
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.04.2020
• Subjects: bioavailability; Buccal delivery; Drug delivery; encapsulation; gastrointestinal system; Lipid; lipids; metabolism; mucosa; Nanoparticle; nanoparticles; patients; permeability; Permeation enhancer; Polymer; polymers; saliva; therapeutics; tongue; C; STC; D; NLC; o/w/o; PLA; Buccal delivery; Nanoparticle; Drug delivery; J; Permeation enhancer; K; PVP; SDGC; MTT; PEG-b-PLA; SC; BSA; SLN; o/w; w/o; CMC; ɛ; CLSM; w/o/w; Da; Ch-PLA; SDTC; h; Polymer; ER; Lipid; SGC; MCG; LMWH; PEG; PLGA; PdI; EFF-Cg; Log P; PVA; GRAS; HPMC

The buccal route is considered patient friendly due to its non-invasive nature and ease of administration. Such delivery route has been used as an alternative for the delivery of drugs that undergo first-pass metabolism or are susceptible to pH and enzymatic degradation, such as occurs in the gastro...