Novel and revisited approaches in nanoparticle systems for buccal drug delivery

The buccal route is considered patient friendly due to its non-invasive nature and ease of administration. Such delivery route has been used as an alternative for the delivery of drugs that undergo first-pass metabolism or are susceptible to pH and enzymatic degradation, such as occurs in the gastro...

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Published inJournal of controlled release Vol. 320; pp. 125 - 141
Main Authors Macedo, Ana S., Castro, Pedro M., Roque, Luís, Thomé, Natália G., Reis, Catarina P., Pintado, Manuela E., Fonte, Pedro
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 10.04.2020
Subjects
bioavailability
Buccal delivery
Drug delivery
encapsulation
gastrointestinal system
Lipid
lipids
metabolism
mucosa
Nanoparticle
nanoparticles
patients
permeability
Permeation enhancer
Polymer
polymers
saliva
therapeutics
tongue
C
STC
D
NLC
o/w/o
PLA
Buccal delivery
Nanoparticle
Drug delivery
J
Permeation enhancer
K
PVP
SDGC
MTT
PEG-b-PLA
SC
BSA
SLN
o/w
w/o
CMC
ɛ
CLSM
w/o/w
Da
Ch-PLA
SDTC
h
Polymer
ER
Lipid
SGC
MCG
LMWH
PEG
PLGA
PdI
EFF-Cg
Log P
PVA
GRAS
HPMC
Online AccessGet full text

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Abstract The buccal route is considered patient friendly due to its non-invasive nature and ease of administration. Such delivery route has been used as an alternative for the delivery of drugs that undergo first-pass metabolism or are susceptible to pH and enzymatic degradation, such as occurs in the gastrointestinal tract. However, the drug concentration absorbed in the buccal mucosa is often low to obtain an acceptable therapeutic effect, mainly due to the saliva turnover, tongue and masticatory movements, phonation, enzymatic degradation and lack of epithelium permeation. Therefore, the encapsulation of drugs into nanoparticles is an important strategy to avoid such problems and improve their buccal delivery. Different materials from lipids to natural or synthetic polymers and others have been used to protect and deliver drugs in a sustained, controlled or targeted manner, and enhance their uptake through the buccal mucosa improving their bioavailability and therapeutic outcome. Overall, the main aim of this review is to perform an overview about the nanotechnological approaches developed so far to improve the buccal delivery of drugs. Herein, several types of nanoparticles and delivery strategies are addressed, and a special focus on pipeline products is also given. [Display omitted] •Buccal drug delivery is an important non-invasive route for drug delivery.•Nanoparticles are good carriers to avoid the disadvantages of buccal drug delivery.•Nanoparticles are usually incorporated into matrix/gel systems for buccal delivery.•Permeation enhancers and enzyme inhibitors enhance buccal drug delivery.•Nanoparticle features may define the fate of drugs in the oral cavity.
AbstractList The buccal route is considered patient friendly due to its non-invasive nature and ease of administration. Such delivery route has been used as an alternative for the delivery of drugs that undergo first-pass metabolism or are susceptible to pH and enzymatic degradation, such as occurs in the gastrointestinal tract. However, the drug concentration absorbed in the buccal mucosa is often low to obtain an acceptable therapeutic effect, mainly due to the saliva turnover, tongue and masticatory movements, phonation, enzymatic degradation and lack of epithelium permeation. Therefore, the encapsulation of drugs into nanoparticles is an important strategy to avoid such problems and improve their buccal delivery. Different materials from lipids to natural or synthetic polymers and others have been used to protect and deliver drugs in a sustained, controlled or targeted manner, and enhance their uptake through the buccal mucosa improving their bioavailability and therapeutic outcome. Overall, the main aim of this review is to perform an overview about the nanotechnological approaches developed so far to improve the buccal delivery of drugs. Herein, several types of nanoparticles and delivery strategies are addressed, and a special focus on pipeline products is also given.
The buccal route is considered patient friendly due to its non-invasive nature and ease of administration. Such delivery route has been used as an alternative for the delivery of drugs that undergo first-pass metabolism or are susceptible to pH and enzymatic degradation, such as occurs in the gastrointestinal tract. However, the drug concentration absorbed in the buccal mucosa is often low to obtain an acceptable therapeutic effect, mainly due to the saliva turnover, tongue and masticatory movements, phonation, enzymatic degradation and lack of epithelium permeation. Therefore, the encapsulation of drugs into nanoparticles is an important strategy to avoid such problems and improve their buccal delivery. Different materials from lipids to natural or synthetic polymers and others have been used to protect and deliver drugs in a sustained, controlled or targeted manner, and enhance their uptake through the buccal mucosa improving their bioavailability and therapeutic outcome. Overall, the main aim of this review is to perform an overview about the nanotechnological approaches developed so far to improve the buccal delivery of drugs. Herein, several types of nanoparticles and delivery strategies are addressed, and a special focus on pipeline products is also given. [Display omitted] •Buccal drug delivery is an important non-invasive route for drug delivery.•Nanoparticles are good carriers to avoid the disadvantages of buccal drug delivery.•Nanoparticles are usually incorporated into matrix/gel systems for buccal delivery.•Permeation enhancers and enzyme inhibitors enhance buccal drug delivery.•Nanoparticle features may define the fate of drugs in the oral cavity.
The buccal route is considered patient friendly due to its non-invasive nature and ease of administration. Such delivery route has been used as an alternative for the delivery of drugs that undergo first-pass metabolism or are susceptible to pH and enzymatic degradation, such as occurs in the gastrointestinal tract. However, the drug concentration absorbed in the buccal mucosa is often low to obtain an acceptable therapeutic effect, mainly due to the saliva turnover, tongue and masticatory movements, phonation, enzymatic degradation and lack of epithelium permeation. Therefore, the encapsulation of drugs into nanoparticles is an important strategy to avoid such problems and improve their buccal delivery. Different materials from lipids to natural or synthetic polymers and others have been used to protect and deliver drugs in a sustained, controlled or targeted manner, and enhance their uptake through the buccal mucosa improving their bioavailability and therapeutic outcome. Overall, the main aim of this review is to perform an overview about the nanotechnological approaches developed so far to improve the buccal delivery of drugs. Herein, several types of nanoparticles and delivery strategies are addressed, and a special focus on pipeline products is also given.The buccal route is considered patient friendly due to its non-invasive nature and ease of administration. Such delivery route has been used as an alternative for the delivery of drugs that undergo first-pass metabolism or are susceptible to pH and enzymatic degradation, such as occurs in the gastrointestinal tract. However, the drug concentration absorbed in the buccal mucosa is often low to obtain an acceptable therapeutic effect, mainly due to the saliva turnover, tongue and masticatory movements, phonation, enzymatic degradation and lack of epithelium permeation. Therefore, the encapsulation of drugs into nanoparticles is an important strategy to avoid such problems and improve their buccal delivery. Different materials from lipids to natural or synthetic polymers and others have been used to protect and deliver drugs in a sustained, controlled or targeted manner, and enhance their uptake through the buccal mucosa improving their bioavailability and therapeutic outcome. Overall, the main aim of this review is to perform an overview about the nanotechnological approaches developed so far to improve the buccal delivery of drugs. Herein, several types of nanoparticles and delivery strategies are addressed, and a special focus on pipeline products is also given.
Author Castro, Pedro M.
Reis, Catarina P.
Macedo, Ana S.
Fonte, Pedro
Pintado, Manuela E.
Roque, Luís
Thomé, Natália G.
Author_xml – sequence: 1
  givenname: Ana S.
  surname: Macedo
  fullname: Macedo, Ana S.
  organization: LAQV, REQUIMTE, Department of Chemical Sciences - Applied Chemistry Lab, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal
– sequence: 2
  givenname: Pedro M.
  surname: Castro
  fullname: Castro, Pedro M.
  organization: CBQF — Centro de Biotecnologia e Química Fina — Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Rua Arquiteto Lobão Vital, 172, 4200-374 Porto, Portugal
– sequence: 3
  givenname: Luís
  surname: Roque
  fullname: Roque, Luís
  organization: CBIOS, Universidade Lusófona Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749-024 Lisboa, Portugal
– sequence: 4
  givenname: Natália G.
  surname: Thomé
  fullname: Thomé, Natália G.
  organization: Center for Marine Sciences (CCMar), University of Algarve, Gambelas Campus, 8005-139 Faro, Portugal
– sequence: 5
  givenname: Catarina P.
  surname: Reis
  fullname: Reis, Catarina P.
  organization: iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649–003 Lisboa, Portugal
– sequence: 6
  givenname: Manuela E.
  surname: Pintado
  fullname: Pintado, Manuela E.
  organization: CBQF — Centro de Biotecnologia e Química Fina — Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Rua Arquiteto Lobão Vital, 172, 4200-374 Porto, Portugal
– sequence: 7
  givenname: Pedro
  orcidid: 0000-0002-1115-9282
  surname: Fonte
  fullname: Fonte, Pedro
  email: prfonte@ualg.pt
  organization: Center for Marine Sciences (CCMar), University of Algarve, Gambelas Campus, 8005-139 Faro, Portugal
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31917295$$D View this record in MEDLINE/PubMed
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Snippet The buccal route is considered patient friendly due to its non-invasive nature and ease of administration. Such delivery route has been used as an alternative...
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SubjectTerms bioavailability
Buccal delivery
Drug delivery
encapsulation
gastrointestinal system
Lipid
lipids
metabolism
mucosa
Nanoparticle
nanoparticles
patients
permeability
Permeation enhancer
Polymer
polymers
saliva
therapeutics
tongue
Title Novel and revisited approaches in nanoparticle systems for buccal drug delivery
URI https://dx.doi.org/10.1016/j.jconrel.2020.01.006
https://www.ncbi.nlm.nih.gov/pubmed/31917295
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Volume 320
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