Radiosynthesis and Evaluation of a C-11 Radiotracer for Transient Receptor Potential Canonical 5 in the Brain

• Vydáno v: Molecular imaging and biology Ročník 25; číslo 2; s. 334 - 342
• Hlavní autoři: Yu, Yanbo, Jiang, Hao, Liang, Qianwa, Qiu, Lin, Huang, Tianyu, Hu, Hongzhen, Bolshakov, Vadim Y., Perlmutter, Joel S., Tu, Zhude
• Typ dokumentu: Článek v odborném časopise
• Jazyk: angličtina
• Vydáno: Cham Springer International Publishing 01.04.2023; Springer Nature B.V
• Témata: Animals; Autoradiography; Biodistribution; Brain; Brain - metabolism; Calcium channels; Calcium ions; Calcium permeability; Carbon Radioisotopes - chemistry; Clearances; Data acquisition; Humans; Imaging; Intravenous administration; Male; Mammals - metabolism; Medicine; Medicine & Public Health; Methylation; Mice; Mice, Knockout; Neuroimaging; Pharmacokinetics; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Primates; Primates - metabolism; Radioactive tracers; Radiochemistry; Radiology; Radiopharmaceuticals - pharmacokinetics; Rats; Rats, Sprague-Dawley; Receptors; Research Article; Rodents; Tissue Distribution; Transient receptor potential proteins; TRPC Cation Channels - metabolism; TRPC 5; Carbon-11 Radiotracer; PET Imaging; Ionic Channel
• On-line přístup: Získat plný text
• ISSN: 1536-1632; 1860-2002; 1860-2002
• DOI: 10.1007/s11307-022-01760-y

Purpose TRPC5 belongs to the mammalian superfamily of transient receptor potential (TRP) Ca 2+ -permeable cationic channels and it has been implicated in various CNS disorders. As part of our ongoing interest in the development of a PET radiotracer for imaging TRPC5, herein, we explored the radiosyn...