Reciprocal regulation of TWIST1 and OGT determines the decitabine efficacy in MDS/AML

• Published in: Cell communication and signaling Vol. 21; no. 1; pp. 1 - 12
• Main Authors: Li, Hongjiao, Wang, Yi, Feng, Shuang, Chang, Kaijing, Yu, Xinwen, Yang, Fenfang, Huang, Haozhe, Wang, Yuanbo, Li, Xiang, Guan, Feng
• Format: Journal Article
• Language: English
• Published: London BioMed Central 22.09.2023; BMC
• Subjects: 5-aza-2'-deoxycytidine; Acute myeloid leukemia; Antibodies; CD34 antigen; Cells; Chemoresistance; DAC resistance; DNA methyltransferase; Leukemia; MDS/AML; Myelodysplastic syndrome; O-GlcNAc; O-GlcNAcylation; OGT; Peptides; Proteins; TWIST1; Ubiquitin-protein ligase; United States > US; China

Chemoresistance poses a significant impediment to effective treatment strategies for myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Our previous study unveiled that oncogene TWIST1 interacted with DNA methyltransferase 3a (DNMT3a) to regulate the decitabine (DAC) resistance in MDS...