Cigarette smoke affects the onco-suppressor DAB2IP expression in bronchial epithelial cells of COPD patients

• Published in: Scientific reports Vol. 9; no. 1; pp. 15682 - 14
• Main Authors: Anzalone, Giulia, Arcoleo, Giuseppe, Bucchieri, Fabio, Montalbano, Angela M., Marchese, Roberto, Albano, Giusy D., Di Sano, Caterina, Moscato, Monica, Gagliardo, Rosalia, Ricciardolo, Fabio L. M., Profita, Mirella
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.10.2019; Nature Publishing Group
• Subjects: 13; 13/106; 13/2; 13/31; 13/51; 692/420/256; 692/420/755; 82; 82/1; 82/79; 96; 96/31; A549 Cells; Alveolar Epithelial Cells - drug effects; Alveolar Epithelial Cells - pathology; Apoptosis; Apoptosis - drug effects; Chronic obstructive pulmonary disease; Cigar Smoking - adverse effects; Cigarette smoke; Cigarettes; DNA methylation; Enhancer of Zeste Homolog 2 Protein - genetics; Epithelial cells; Epithelium; Gene Expression Regulation, Neoplastic - drug effects; Histone H3; Humanities and Social Sciences; Humans; Immunoreactivity; Invasiveness; Jumonji Domain-Containing Histone Demethylases - genetics; Lung cancer; Lung Neoplasms - chemically induced; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Lysine; Mesenchyme; Molecular modelling; multidisciplinary; Neoplasm Invasiveness - genetics; Neoplasm Invasiveness - pathology; Pulmonary Disease, Chronic Obstructive - chemically induced; Pulmonary Disease, Chronic Obstructive - genetics; Pulmonary Disease, Chronic Obstructive - pathology; ras GTPase-Activating Proteins - genetics; Respiratory tract diseases; Risk Factors; Science; Science (multidisciplinary); Tobacco smoke; Tumor cell lines; Vimentin

Cigarette smoke is a risk factor for COPD and lung cancer. In cancer, epigenetic modifications affect the expression of Enhancer of Zester Homolog 2 (EZH2), and silenced disabled homolog 2 interacting protein gene (DAB2IP) (onco-suppressor gene) by Histone H3 tri-methylation in lysine 27 (H3K27me3)....