Abnormal expression of miR-3653-3p, caspase 1, IL-1β in peripheral blood of schizophrenia

• Published in: BMC psychiatry Vol. 23; no. 1; pp. 1 - 10
• Main Authors: Zhao, Xin-ling, Liu, Yi-lin, Long, Qing, Zhang, Yun-qiao, You, Xu, Guo, Ze-yi, Cao, Xiang, Yu, Lei, Qin, Fu-yi, Teng, Zhao-wei, Zeng, Yong
• Format: Journal Article
• Language: English
• Published: London BioMed Central 09.11.2023; BMC
• Subjects: Antipsychotics; Binding sites; Biomarkers; Caspase 1; Correlation analysis; Emotional behavior; Enzymes; Gene expression; IL-1β; Inflammation; Mental disorders; MicroRNAs; miR-3653-3p; miRNA; Molecular modelling; mRNA; Next-generation sequencing; NLRP3; Patients; Peripheral blood; Psychiatry; Psychopathology; Psychotropic drugs; qPCR; Schizophrenia; Statistical analysis

Schizophrenia (SCZ) is a chronic, highly relapsing, severe mental disorder with an unclear etiology. Cytokine-mediated neuroimmune abnormalities have been repeatedly revealed. IL-1β was reported to play a vital role in expanding the inflammatory response. However, the underlying molecular mechanism...