Chemical-induced epigenome resetting for regeneration program activation in human cells

• Published in: Cell reports (Cambridge) Vol. 42; no. 6; p. 112547
• Main Authors: Wang, Guan, Wang, Yanglu, Lyu, Yulin, He, Huanjing, Liuyang, Shijia, Wang, Jinlin, Sun, Shicheng, Cheng, Lin, Fu, Yao, Zhu, Jialiang, Zhong, Xinxing, Yang, Zhihan, Chen, Qijing, Li, Cheng, Guan, Jingyang, Deng, Hongkui
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.06.2023; Elsevier
• Subjects: activation of regeneration-like program; chemical reprogramming; CP: Stem cell research; enhancer recommissioning; epigenome remodeling; reboot regeneration potential; epigenome remodeling; enhancer recommissioning; CP: Stem cell research; chemical reprogramming; activation of regeneration-like program; reboot regeneration potential

Human somatic cells can be reprogrammed to pluripotent stem cells by small molecules through an intermediate stage with a regeneration signature, but how this regeneration state is induced remains largely unknown. Here, through integrated single-cell analysis of transcriptome, we demonstrate that th...