Nonalcoholic fatty liver disease: an overview of current insights in pathogenesis, diagnosis and treatment

• Published in: World journal of gastroenterology : WJG Vol. 14; no. 16; pp. 2474 - 2486
• Main Authors: Schreuder, Tim C M A, Verwer, Bart J, van Nieuwkerk, Carin M J, Mulder, Chris J J
• Format: Journal Article
• Language: English
• Published: United States Department of Gastroenterology and Hepatology,VU University Medical Center, Amsterdam 1007, The Netherlands 28.04.2008; The WJG Press and Baishideng
• Subjects: Adipocytes - cytology; Adipocytes - pathology; Adipocytes - physiology; Fatigue - etiology; Fatty Acids, Nonesterified - blood; Fatty Liver - classification; Fatty Liver - diagnosis; Fatty Liver - etiology; Fatty Liver - therapy; Humans; Insulin Resistance; Leptin - physiology; Lipids - biosynthesis; Liver - physiology; Liver Failure - etiology; Liver Failure - pathology; Liver Failure - physiopathology; Pain - etiology; Reference Values; Review; Obesity; Insulin resistance; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Liver; Steatosis

Estimates of people suffering from overweight (one billion) and obesity (300 million) are increasing. The accumulation of triglycerides in the liver, in the absence of excess alcohol intake, has been described in the early sixties. It was not until 1980, however, that Ludwig et al named this conditi...