Rheumatoid arthritis patient antibodies highly recognize IL-2 in the immune response pathway involving IRF5 and EBV antigens

• Published in: Scientific reports Vol. 8; no. 1; pp. 1789 - 8
• Main Authors: Bo, Marco, Niegowska, Magdalena, Erre, Gian Luca, Piras, Marco, Longu, Maria Giovanna, Manchia, Pierangela, Manca, Mario, Passiu, Giuseppe, Sechi, Leonardo A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.01.2018; Nature Publishing Group
• Subjects: 14; 631/250/38; 692/4023; 82/1; 82/75; 82/79; Antibodies; Antibodies, Viral - immunology; Antigens; Antigens, Viral - immunology; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - virology; Autoimmune diseases; Autoimmune Diseases - immunology; Autoimmune Diseases - virology; Case-Control Studies; Cross Reactions - immunology; Cross-reaction; Environmental factors; Epitopes; Epitopes - immunology; Epstein-Barr virus; Epstein-Barr Virus Infections - immunology; Female; Genomes; Herpesvirus 4, Human - immunology; Humanities and Social Sciences; Humans; Immune response; Immunological tolerance; Interferon regulatory factor; Interferon Regulatory Factors - immunology; Interleukin 2; Interleukin-2 - immunology; Lymphocytes T; Male; Middle Aged; Mimicry; Molecular Mimicry - immunology; multidisciplinary; Rheumatoid arthritis; Science; Science (multidisciplinary)

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a progressive joint damage due to largely unknown environmental factors acting in concert with risk alleles conferring genetic susceptibility. A major role has been attributed to viral infections that include past contacts wi...