The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent

• Published in: Scientific reports Vol. 10; no. 1; p. 7908
• Main Authors: Skopelja-Gardner, Sladjana, An, Jie, Tai, Joyce, Tanaka, Lena, Sun, Xizhang, Hermanson, Payton, Baum, Rebecca, Kawasumi, Masaoki, Green, Richard, Gale Jr, Michael, Kalus, Andrea, Werth, Victoria P., Elkon, Keith B.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.05.2020; Nature Publishing Group
• Subjects: 631/250; 692/4023; Animals; Blood; Cytokines - metabolism; Dermatitis - etiology; Dermatitis - metabolism; Dermatitis - pathology; Disease Models, Animal; Disease Susceptibility; Environmental Exposure; Female; Humanities and Social Sciences; Humans; Inflammation; Inflammation Mediators - metabolism; Interferon; Interferon Type I - biosynthesis; Kidneys; Male; Mice; Mice, Knockout; multidisciplinary; Nucleotidyltransferases - genetics; Nucleotidyltransferases - metabolism; Science; Science (multidisciplinary); Sex Factors; Skin - metabolism; Skin - pathology; Skin - radiation effects; Skin diseases; Systemic lupus erythematosus; Ultraviolet radiation; Ultraviolet Rays - adverse effects

Most systemic lupus erythematosus (SLE) patients are photosensitive and ultraviolet B light (UVB) exposure worsens cutaneous disease and precipitates systemic flares of disease. The pathogenic link between skin disease and systemic exacerbations in SLE remains elusive. In an acute model of UVB-trigg...