TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation

• Published in: Cell reports (Cambridge) Vol. 43; no. 8; p. 114604
• Main Authors: Hou, Jihuan, Mei, Kunrong, Wang, Daxuan, Ke, Sunkui, Chen, Xiong, Shang, Jin, Li, Guixia, Gao, Yan, Xiong, Huifang, Zhang, Haoran, Chen, Lu, Zhang, Wenqing, Deng, Yabin, Hong, Xiaoting, Liu, Di-Ao, Hu, Tianhui, Guo, Wei, Zhan, Yan-yan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.08.2024; Elsevier
• Subjects: AMP-Activated Protein Kinase Kinases; Animals; Cell Line, Tumor; Cell Movement - drug effects; CP: Cancer; CP: Cell biology; Exo70; Humans; LKB1; metastasis; Mice; Mice, Nude; Neoplasm Metastasis; Phosphorylation - drug effects; Protein Serine-Threonine Kinases - metabolism; transamidation; transglutaminase; Transglutaminases - metabolism; Vesicular Transport Proteins - genetics; Vesicular Transport Proteins - metabolism; Exo70; transglutaminase; CP: Cell biology; metastasis; CP: Cancer; LKB1; transamidation

Exo70, a key exocyst complex component, is crucial for cell motility and extracellular matrix (ECM) remodeling in cancer metastasis. Despite its potential as a drug target, Exo70’s post-translational modifications (PTMs) are poorly characterized. Here, we report that Exo70 is transamidated on Gln5 w...