Combining transcatheter arterial embolization with iodized oil containing Apatinib inhibits HCC growth and metastasis

• Published in: Scientific reports Vol. 10; no. 1; p. 2964
• Main Authors: Zhou, Chen, Yao, Qi, Zhang, Hongsen, Guo, Xiaopeng, Liu, Jiacheng, Shi, Qin, Huang, Songjiang, Xiong, Bin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.02.2020; Nature Publishing Group
• Subjects: 1-Phosphatidylinositol 3-kinase; 13/2; 692/4028/67/1059/602; 692/4028/67/2327; 692/4028/67/2328; 82/51; AKT protein; Angiogenesis; Animal research; Animals; Antineoplastic Agents - administration & dosage; Antitumor activity; Apoptosis; Apoptosis - drug effects; Bioassays; Carcinoma, Hepatocellular - blood supply; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - therapy; Cell adhesion & migration; Cell migration; Cell Movement - drug effects; Cell Proliferation - drug effects; Chemoembolization, Therapeutic - methods; Embolization; Endothelial cells; Gene Expression Regulation, Neoplastic - drug effects; Hep G2 Cells; Human Umbilical Vein Endothelial Cells; Humanities and Social Sciences; Humans; Hypoxia; Iodized Oil - administration & dosage; Liver cancer; Liver Neoplasms - blood supply; Liver Neoplasms - genetics; Liver Neoplasms - therapy; MAP Kinase Signaling System - drug effects; Metastases; Metastasis; Mice; multidisciplinary; Neovascularization, Pathologic - therapy; Oil; Phosphorylation; Phosphorylation - drug effects; Pyridines - administration & dosage; Raf protein; Science; Science (multidisciplinary); Tumor Microenvironment - drug effects; Tumors; Umbilical vein; Wound healing; Xenograft Model Antitumor Assays

Transcatheter arterial embolization (TAE) plays an important role in clinical liver tumor therapy. However, hypoxia after TAE limit the medium-long term efficacy of TAE. Thus, in our study, we explored the treatment effect and mechanism of combining transcatheter arterial embolization with adopted i...