YAP/TAZ drives cell proliferation and tumour growth via a polyamine–eIF5A hypusination–LSD1 axis
Metabolic reprogramming is central to oncogene-induced tumorigenesis by providing the necessary building blocks and energy sources, but how oncogenic signalling controls metabolites that play regulatory roles in driving cell proliferation and tumour growth is less understood. Here we show that oncog...
Saved in:
Published in | Nature cell biology Vol. 24; no. 3; pp. 373 - 383 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.03.2022
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Metabolic reprogramming is central to oncogene-induced tumorigenesis by providing the necessary building blocks and energy sources, but how oncogenic signalling controls metabolites that play regulatory roles in driving cell proliferation and tumour growth is less understood. Here we show that oncogene YAP/TAZ promotes polyamine biosynthesis by activating the transcription of the rate-limiting enzyme ornithine decarboxylase 1. The increased polyamine levels, in turn, promote the hypusination of eukaryotic translation factor 5A (eIF5A) to support efficient translation of histone demethylase LSD1, a transcriptional repressor that mediates a bulk of YAP/TAZ-downregulated genes including tumour suppressors in YAP/TAZ-activated cells. Accentuating the importance of the YAP/TAZ–polyamine–eIF5A hypusination–LSD1 axis, inhibiting polyamine biosynthesis or LSD1 suppressed YAP/TAZ-induced cell proliferation and tumour growth. Given the frequent upregulation of YAP/TAZ activity and polyamine levels in diverse cancers, our identification of YAP/TAZ as an upstream regulator and LSD1 as a downstream effector of the oncometabolite polyamine offers a molecular framework in which oncogene-induced metabolic and epigenetic reprogramming coordinately drives tumorigenesis, and suggests potential therapeutic strategies in YAP/TAZ- or polyamine-dependent human malignancies.
Li et al. show that YAP/TAZ directly promotes polyamine biosynthesis and activates eIF5A activity to upregulate LSD1 expression, thereby suppressing various genes including tumour suppressors to enhance tumour growth. |
---|---|
AbstractList | Metabolic reprogramming is central to oncogene-induced tumorigenesis by providing the necessary building blocks and energy sources, but how oncogenic signalling controls metabolites that play regulatory roles in driving cell proliferation and tumour growth is less understood. Here we show that oncogene YAP/TAZ promotes polyamine biosynthesis by activating the transcription of the rate-limiting enzyme ornithine decarboxylase 1. The increased polyamine levels, in turn, promote the hypusination of eukaryotic translation factor 5A (eIF5A) to support efficient translation of histone demethylase LSD1, a transcriptional repressor that mediates a bulk of YAP/TAZ-downregulated genes including tumour suppressors in YAP/TAZ-activated cells. Accentuating the importance of the YAP/TAZ–polyamine–eIF5A hypusination–LSD1 axis, inhibiting polyamine biosynthesis or LSD1 suppressed YAP/TAZ-induced cell proliferation and tumour growth. Given the frequent upregulation of YAP/TAZ activity and polyamine levels in diverse cancers, our identification of YAP/TAZ as an upstream regulator and LSD1 as a downstream effector of the oncometabolite polyamine offers a molecular framework in which oncogene-induced metabolic and epigenetic reprogramming coordinately drives tumorigenesis, and suggests potential therapeutic strategies in YAP/TAZ- or polyamine-dependent human malignancies.Li et al. show that YAP/TAZ directly promotes polyamine biosynthesis and activates eIF5A activity to upregulate LSD1 expression, thereby suppressing various genes including tumour suppressors to enhance tumour growth. Metabolic reprogramming is central to oncogene-induced tumorigenesis by providing the necessary building blocks and energy sources, but how oncogenic signalling controls metabolites that play regulatory roles in driving cell proliferation and tumour growth is less understood. Here we show that oncogene YAP/TAZ promotes polyamine biosynthesis by activating the transcription of the rate-limiting enzyme ornithine decarboxylase 1. The increased polyamine levels, in turn, promote the hypusination of eukaryotic translation factor 5A (eIF5A) to support efficient translation of histone demethylase LSD1, a transcriptional repressor that mediates a bulk of YAP/TAZ-downregulated genes including tumour suppressors in YAP/TAZ-activated cells. Accentuating the importance of the YAP/TAZ–polyamine–eIF5A hypusination–LSD1 axis, inhibiting polyamine biosynthesis or LSD1 suppressed YAP/TAZ-induced cell proliferation and tumour growth. Given the frequent upregulation of YAP/TAZ activity and polyamine levels in diverse cancers, our identification of YAP/TAZ as an upstream regulator and LSD1 as a downstream effector of the oncometabolite polyamine offers a molecular framework in which oncogene-induced metabolic and epigenetic reprogramming coordinately drives tumorigenesis, and suggests potential therapeutic strategies in YAP/TAZ- or polyamine-dependent human malignancies. Li et al. show that YAP/TAZ directly promotes polyamine biosynthesis and activates eIF5A activity to upregulate LSD1 expression, thereby suppressing various genes including tumour suppressors to enhance tumour growth. Metabolic reprogramming is central to oncogene-induced tumorigenesis by providing the necessary building blocks and energy sources, but how oncogenic signalling controls metabolites that play regulatory roles in driving cell proliferation and tumour growth is less understood. Here we show that oncogene YAP/TAZ promotes polyamine biosynthesis by activating the transcription of the rate-limiting enzyme ornithine decarboxylase 1. The increased polyamine levels, in turn, promote the hypusination of eukaryotic translation factor 5A (eIF5A) to support efficient translation of histone demethylase LSD1, a transcriptional repressor that mediates a bulk of YAP/TAZ-downregulated genes including tumour suppressors in YAP/TAZ-activated cells. Accentuating the importance of the YAP/TAZ-polyamine-eIF5A hypusination-LSD1 axis, inhibiting polyamine biosynthesis or LSD1 suppressed YAP/TAZ-induced cell proliferation and tumour growth. Given the frequent upregulation of YAP/TAZ activity and polyamine levels in diverse cancers, our identification of YAP/TAZ as an upstream regulator and LSD1 as a downstream effector of the oncometabolite polyamine offers a molecular framework in which oncogene-induced metabolic and epigenetic reprogramming coordinately drives tumorigenesis, and suggests potential therapeutic strategies in YAP/TAZ- or polyamine-dependent human malignancies. Metabolic reprogramming is central to oncogene-induced tumorigenesis by providing the necessary building blocks and energy sources, but how oncogenic signaling controls metabolites that play regulatory roles in driving cell proliferation and tumor growth is less understood. Here we show that oncogene YAP/TAZ promotes polyamine biosynthesis by activating the transcription of the rate-limiting enzyme ornithine decarboxylase 1. The increased polyamine levels, in turn, promote the hypusination of eukaryotic translation factor 5A (eIF5A) to support efficient translation of histone demethylase LSD1, a transcriptional repressor that mediates a bulk of YAP/TAZ-downregulated genes including tumor suppressors in YAP/TAZ-activated cells. Accentuating the importance of the YAP/TAZ-polyamine-eIF5A hypusination-LSD1 axis, inhibiting polyamine biosynthesis or LSD1 suppressed YAP/TAZ-induced cell proliferation and tumor growth significantly. Given the frequent upregulation of YAP/TAZ activity and polyamine levels in diverse cancers, our identification of YAP/TAZ as an upstream regulator and LSD1 as a downstream effector of the oncometabolite polyamine offers a molecular framework in which oncogene-induced metabolic and epigenetic reprogramming coordinately drives tumorigenesis, and suggests potential therapeutic strategies in YAP/TAZ- or polyamine-dependent human malignancies. |
Author | Wu, Bo-Kuan Cai, Jing Wang, Li Li, Hongde Zheng, Yonggang Kanchwala, Mohammed Pan, Duojia Xing, Chao |
AuthorAffiliation | 1 Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9040, USA 2 Eugene McDermott Center for Human Growth and Development/Center for Human Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9040, USA |
AuthorAffiliation_xml | – name: 2 Eugene McDermott Center for Human Growth and Development/Center for Human Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9040, USA – name: 1 Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9040, USA |
Author_xml | – sequence: 1 givenname: Hongde orcidid: 0000-0003-1256-2513 surname: Li fullname: Li, Hongde organization: Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center – sequence: 2 givenname: Bo-Kuan surname: Wu fullname: Wu, Bo-Kuan organization: Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center – sequence: 3 givenname: Mohammed orcidid: 0000-0001-6035-2970 surname: Kanchwala fullname: Kanchwala, Mohammed organization: Eugene McDermott Center for Human Growth and Development/Center for Human Genetics, University of Texas Southwestern Medical Center – sequence: 4 givenname: Jing surname: Cai fullname: Cai, Jing organization: Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center – sequence: 5 givenname: Li surname: Wang fullname: Wang, Li organization: Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center – sequence: 6 givenname: Chao orcidid: 0000-0002-1838-0502 surname: Xing fullname: Xing, Chao organization: Eugene McDermott Center for Human Growth and Development/Center for Human Genetics, University of Texas Southwestern Medical Center – sequence: 7 givenname: Yonggang orcidid: 0000-0002-3326-4614 surname: Zheng fullname: Zheng, Yonggang organization: Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center – sequence: 8 givenname: Duojia orcidid: 0000-0003-2890-4645 surname: Pan fullname: Pan, Duojia email: duojia.pan@utsouthwestern.edu organization: Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35177822$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kbtuFDEUhi0URC7wAhTIEg3NEN89bpBWIYFIK4FEKKCxPGPvrqMZe7BnNtku78Ab5knizYZwKahs-Xz_f3zOfwj2QgwOgJcYvcWI1seZYc5FhQipEKpZXfEn4AAzKSompNrb3gWvJFVkHxzmfIkQZgzJZ2CfcixlTcgBsN9mn48vZt-hTX7tMmxd18Ehxc4vXDKjjwGaYOE49XFKcJni1biCa2-ggUPsNqb3wd3e_HTnZ3wGV5thyj7cy8rj_Mt7DM21z8_B04XpsnvxcB6Br2enFycfq_mnD-cns3nVMsnGSjDqGkmobSSuUU2bxmJGamkMIg2nkpFWidZIJ61EhighsFWWLrizhDYE0SPwbuc7TE3vbOvCmEynh-R7kzY6Gq__rgS_0su41rWiiCNaDN48GKT4Y3J51L3P25WY4OKUNREUKawQlwV9_Q96WTYUynhbSmGKakwKRXZUm2LOyS0eP4OR3oaodyHqEqK-D1HzInr15xiPkl-pFYDugFxKYenS797_sb0DS26rTQ |
CitedBy_id | crossref_primary_10_3390_ijms25126340 crossref_primary_10_1007_s12672_024_00947_9 crossref_primary_10_3390_cells13080707 crossref_primary_10_3390_jpm12101544 crossref_primary_10_2139_ssrn_4135063 crossref_primary_10_1038_s41580_023_00644_5 crossref_primary_10_1038_s41388_023_02810_7 crossref_primary_10_1038_s41467_024_46776_w crossref_primary_10_1177_20420188231220134 crossref_primary_10_1515_oncologie_2023_0562 crossref_primary_10_1016_j_biopha_2022_113903 crossref_primary_10_1186_s12943_024_02031_w crossref_primary_10_1186_s13046_023_02704_2 crossref_primary_10_1053_j_gastro_2023_05_041 crossref_primary_10_1016_j_pharmthera_2022_108334 crossref_primary_10_1164_rccm_202401_0195ED crossref_primary_10_1016_j_cbd_2024_101236 crossref_primary_10_1038_s41467_023_44542_y crossref_primary_10_3389_fimmu_2023_1170773 crossref_primary_10_3390_ijms24020970 crossref_primary_10_1038_s41467_023_39009_z crossref_primary_10_1007_s40820_022_00894_6 crossref_primary_10_1016_j_ijbiomac_2024_132473 crossref_primary_10_1016_j_radmp_2023_10_006 crossref_primary_10_1002_smtd_202301295 crossref_primary_10_1016_j_biopha_2023_114549 crossref_primary_10_1016_j_ejphar_2024_176804 crossref_primary_10_1242_bio_059647 crossref_primary_10_1096_fj_202302251R crossref_primary_10_1016_j_intimp_2022_109405 crossref_primary_10_1002_advs_202301645 crossref_primary_10_3390_pharmaceutics14061215 crossref_primary_10_1093_nsr_nwad028 crossref_primary_10_1016_j_apsb_2024_01_005 |
Cites_doi | 10.1074/jbc.R500031200 10.1073/pnas.78.5.2869 10.1126/science.aaw5473 10.1101/gad.1664408 10.1038/ncb3216 10.1016/j.cmet.2015.12.006 10.1016/j.cell.2004.12.012 10.1074/jbc.M900843200 10.1016/j.it.2020.09.007 10.1016/j.ccell.2016.05.005 10.1016/j.devcel.2019.06.003 10.1016/j.cmet.2018.07.010 10.1016/j.molcel.2019.08.005 10.1080/15548627.2018.1520546 10.1073/pnas.0912203107 10.1016/S0021-9258(19)38631-4 10.1126/science.aan2788 10.1016/j.cell.2007.07.019 10.1038/ncomms11961 10.1016/j.molcel.2013.04.021 10.1016/j.molcel.2015.09.001 10.1016/j.tem.2018.04.006 10.1093/nar/gkx247 10.1038/s41568-018-0050-3 10.1016/j.celrep.2016.06.002 10.1007/s00726-019-02719-0 10.1126/sciadv.aar2606 10.1016/j.cell.2015.10.044 10.1016/j.cell.2016.12.039 10.1073/pnas.1707514115 10.1186/s13059-016-0897-0 10.1101/gad.1602907 10.1146/annurev-cancerbio-070820-035832 10.1016/j.celrep.2015.03.015 10.7554/eLife.02564 10.1038/nrc.2016.82 10.1073/pnas.0911427107 10.1038/s41586-018-0658-1 10.1002/cpbi.86 10.1016/S0021-9258(17)35750-2 10.1038/nrc2824 10.1016/j.cell.2014.11.021 10.2217/epi-2016-0009 10.1016/j.devcel.2020.06.025 10.1074/jbc.270.15.8660 10.1038/nature14222 10.1038/nature10137 10.1016/j.cell.2018.03.035 10.1038/onc.2011.8 10.1038/nature22964 10.1038/nature08617 10.1016/j.cell.2013.03.004 10.1038/nrc1454 10.1101/gad.1978810 10.1038/nature14217 10.1093/nar/gkz348 10.1016/S0021-9258(18)48472-4 10.1038/s41591-018-0158-8 10.1016/j.cell.2018.05.052 10.1016/j.celrep.2021.109347 10.1186/s13059-018-1519-9 |
ContentType | Journal Article |
Copyright | The Author(s), under exclusive licence to Springer Nature Limited 2022 2022. The Author(s), under exclusive licence to Springer Nature Limited. The Author(s), under exclusive licence to Springer Nature Limited 2022. |
Copyright_xml | – notice: The Author(s), under exclusive licence to Springer Nature Limited 2022 – notice: 2022. The Author(s), under exclusive licence to Springer Nature Limited. – notice: The Author(s), under exclusive licence to Springer Nature Limited 2022. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QL 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7X7 7XB 88A 88E 8AO 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7N M7P P64 PQEST PQQKQ PQUKI RC3 7X8 5PM |
DOI | 10.1038/s41556-022-00848-5 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection AUTh Library subscriptions: ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest Central Student Oncogenes and Growth Factors Abstracts Technology Research Database ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection Environmental Sciences and Pollution Management ProQuest Biology Journals (Alumni Edition) ProQuest Central Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Collection AIDS and Cancer Research Abstracts Chemoreception Abstracts ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | ProQuest Central Student MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: AUTh Library subscriptions: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 1476-4679 |
EndPage | 383 |
ExternalDocumentID | 10_1038_s41556_022_00848_5 35177822 |
Genre | Research Support, U.S. Gov't, Non-P.H.S Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
GrantInformation_xml | – fundername: Howard Hughes Medical Institute (HHMI) funderid: https://doi.org/10.13039/100000011 – fundername: U.S. Department of Health & Human Services | National Institutes of Health (NIH) grantid: R01EY015708 funderid: https://doi.org/10.13039/100000002 – fundername: NEI NIH HHS grantid: R01 EY015708 – fundername: Howard Hughes Medical Institute |
GroupedDBID | --- .55 .GJ 0R~ 123 29M 36B 39C 3V. 4.4 53G 5BI 5RE 70F 7X7 88A 88E 8AO 8FE 8FH 8FI 8FJ 8R4 8R5 AAEEF AARCD AAZLF ABAWZ ABCQX ABDBF ABEFU ABJNI ABLJU ABUWG ABVXF ACGFS ACIWK ACNCT ACPRK ADBBV ADQMX AENEX AFBBN AFFNX AFKRA AFRAH AFSHS AFWHJ AGAYW AGEZK AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ AIYXT ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS ARMCB ASPBG AVWKF AXYYD AZFZN B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CS3 D0L DB5 DU5 EAD EAP EBC EBD EBS EE. EJD EMB EMK EMOBN EPL ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA HCIFZ HMCUK HVGLF HZ~ IAO IGS IHR INH INR ISR ITC J5H L-9 L7B LK8 M0L M1P M7P N9A NNMJJ O9- ODYON P2P PQQKQ PROAC PSQYO Q2X QF4 QM4 QN7 QO4 RNS RNT RNTTT SHXYY SIXXV SKT SNYQT SV3 TAOOD TBHMF TDRGL TSG TUS UKHRP X7M Y6R ZGI ~02 ~8M AAYZH CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QL 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. M7N P64 PQEST PQUKI RC3 7X8 AAEXX ABEEJ ADZGE 5PM |
ID | FETCH-LOGICAL-c474t-643eb723db718083bbd14287aa02b53742c96ca7e7d70a29661d9d3f5ed23b203 |
IEDL.DBID | BENPR |
ISSN | 1465-7392 |
IngestDate | Tue Sep 17 21:28:51 EDT 2024 Fri Aug 16 11:43:40 EDT 2024 Thu Oct 10 20:45:30 EDT 2024 Thu Sep 26 18:03:42 EDT 2024 Wed Oct 16 00:40:57 EDT 2024 Fri Oct 11 20:53:08 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Language | English |
License | 2022. The Author(s), under exclusive licence to Springer Nature Limited. Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c474t-643eb723db718083bbd14287aa02b53742c96ca7e7d70a29661d9d3f5ed23b203 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 H.L. and D.P. conceived the project; H.L. and Y.Z. designed experiments; H.L., J.C., L.W. and B.W. performed the experiments; M.K. and C.X. analyzed RNA-seq and ChIP-seq data. D.P. supervised the study; H.L., Y.Z. and D.P. wrote the manuscript. Author contributions |
ORCID | 0000-0001-6035-2970 0000-0002-1838-0502 0000-0003-2890-4645 0000-0002-3326-4614 0000-0003-1256-2513 |
OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC8930503 |
PMID | 35177822 |
PQID | 2639130812 |
PQPubID | 45779 |
PageCount | 11 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_8930503 proquest_miscellaneous_2630919057 proquest_journals_2639130812 crossref_primary_10_1038_s41556_022_00848_5 pubmed_primary_35177822 springer_journals_10_1038_s41556_022_00848_5 |
PublicationCentury | 2000 |
PublicationDate | 2022-03-01 |
PublicationDateYYYYMMDD | 2022-03-01 |
PublicationDate_xml | – month: 03 year: 2022 text: 2022-03-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | London |
PublicationPlace_xml | – name: London – name: England |
PublicationTitle | Nature cell biology |
PublicationTitleAbbrev | Nat Cell Biol |
PublicationTitleAlternate | Nat Cell Biol |
PublicationYear | 2022 |
Publisher | Nature Publishing Group UK Nature Publishing Group |
Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
References | Gutierrez (CR25) 2013; 51 Latour, Gobert, Wilson (CR45) 2020; 52 Zanconato (CR27) 2018; 24 Park, Cooper, Folk (CR22) 1981; 78 Proietti, Rossini, Grohmann, Mondanelli (CR44) 2020; 41 Van der Heiden, De Berardinis (CR4) 2017; 168 Pegg (CR14) 2006; 281 Zhang (CR26) 2019; 76 Casero, Murray Stewart, Pegg (CR13) 2018; 18 Kinnaird, Zhao, Wellen, Michelakis (CR34) 2016; 16 Dupont (CR19) 2011; 474 Zanconato (CR53) 2015; 17 Madeo, Eisenberg, Pietrocola, Kroemer (CR47) 2018; 359 Lee (CR15) 2010; 107 Dong (CR12) 2007; 130 Abbruzzese, Park, Folk (CR23) 1986; 261 Ardestani, Lupse, Maedler (CR11) 2018; 29 Silvera, Formenti, Schneider (CR40) 2010; 10 Zanconato, Cordenonsi, Piccolo (CR6) 2016; 29 Yu, Zhao, Guan (CR5) 2015; 163 Zabala-Letona (CR39) 2017; 547 Chong, Wishart, Xia (CR51) 2019; 68 Qing (CR29) 2014; 3 Chang (CR28) 2018; 563 Dixon (CR57) 2015; 518 Rao (CR58) 2014; 159 Wang (CR60) 2018; 19 Zhang (CR20) 2011; 30 Sheng (CR46) 2018; 174 Lu (CR16) 2010; 107 Leung (CR59) 2015; 518 Galli (CR18) 2015; 60 Wolff, Lee, Chung, Folk, Park (CR24) 1995; 270 Cai (CR49) 2010; 24 Zheng, Pan (CR7) 2019; 50 Koo, Guan (CR10) 2018; 28 Zhao (CR50) 2007; 21 Shi (CR30) 2004; 119 Tang (CR61) 2017; 45 Arruabarrena-Aristorena, Zabala-Letona, Carracedo (CR38) 2018; 4 Izzo, Affronti, Wellen (CR36) 2021; 5 Chung (CR54) 2016; 16 Sanchez-Vega (CR8) 2018; 173 Li, Hsu, Purushotham, Sears, Wang (CR56) 2019; 47 Pavlova, Thompson (CR1) 2016; 23 Jakus, Wolff, Park, Folk (CR32) 1993; 268 Poulin, Lu, Ackermann, Bey, Pegg (CR21) 1992; 267 Zhang (CR33) 2009; 284 Ambrosio, Ballabio, Majello (CR48) 2019; 15 Maiques-Diaz, Somervaille (CR31) 2016; 8 Forester (CR52) 2018; 115 Gerner, Meyskens (CR37) 2004; 4 Kaelin, McKnight (CR35) 2013; 153 Lee (CR43) 2016; 7 Faubert, Solmonson, De Berardinis (CR3) 2020; 368 Ibar, Irvine (CR9) 2020; 54 Dang (CR2) 2009; 462 Hicks-Berthet (CR42) 2021; 36 Kim, Kim, Johnson, Lim (CR41) 2015; 11 Zhao (CR17) 2008; 22 Takaku (CR55) 2016; 17 LT Izzo (848_CR36) 2021; 5 NN Pavlova (848_CR1) 2016; 23 F-X Yu (848_CR5) 2015; 163 GG Galli (848_CR18) 2015; 60 L Dang (848_CR2) 2009; 462 JR Dixon (848_CR57) 2015; 518 EW Gerner (848_CR37) 2004; 4 E Gutierrez (848_CR25) 2013; 51 WG Kaelin (848_CR35) 2013; 153 F Zanconato (848_CR27) 2018; 24 Y Shi (848_CR30) 2004; 119 R Poulin (848_CR21) 1992; 267 A Abbruzzese (848_CR23) 1986; 261 YL Latour (848_CR45) 2020; 52 W Sheng (848_CR46) 2018; 174 S Ambrosio (848_CR48) 2019; 15 Y Zheng (848_CR7) 2019; 50 A Ardestani (848_CR11) 2018; 29 F Zanconato (848_CR53) 2015; 17 B Faubert (848_CR3) 2020; 368 B Zhao (848_CR17) 2008; 22 Z Tang (848_CR61) 2017; 45 H Zhang (848_CR26) 2019; 76 EC Wolff (848_CR24) 1995; 270 Y Qing (848_CR29) 2014; 3 D Li (848_CR56) 2019; 47 JH Koo (848_CR10) 2018; 28 D Silvera (848_CR40) 2010; 10 KP Lee (848_CR15) 2010; 107 SS Rao (848_CR58) 2014; 159 C Ibar (848_CR9) 2020; 54 L Lu (848_CR16) 2010; 107 RA Casero Jr (848_CR13) 2018; 18 L Chang (848_CR28) 2018; 563 AE Pegg (848_CR14) 2006; 281 F Sanchez-Vega (848_CR8) 2018; 173 J Cai (848_CR49) 2010; 24 J Jakus (848_CR32) 1993; 268 E Proietti (848_CR44) 2020; 41 DH Lee (848_CR43) 2016; 7 A Arruabarrena-Aristorena (848_CR38) 2018; 4 F Zanconato (848_CR6) 2016; 29 M Takaku (848_CR55) 2016; 17 M Kim (848_CR41) 2015; 11 Y Wang (848_CR60) 2018; 19 D Leung (848_CR59) 2015; 518 H Zhang (848_CR33) 2009; 284 MG Van der Heiden (848_CR4) 2017; 168 B Zhao (848_CR50) 2007; 21 J Dong (848_CR12) 2007; 130 F Madeo (848_CR47) 2018; 359 MH Park (848_CR22) 1981; 78 A Maiques-Diaz (848_CR31) 2016; 8 CM Forester (848_CR52) 2018; 115 X Zhang (848_CR20) 2011; 30 A Zabala-Letona (848_CR39) 2017; 547 A Kinnaird (848_CR34) 2016; 16 J Chong (848_CR51) 2019; 68 S Dupont (848_CR19) 2011; 474 CY Chung (848_CR54) 2016; 16 J Hicks-Berthet (848_CR42) 2021; 36 |
References_xml | – volume: 281 start-page: 14529 year: 2006 end-page: 14532 ident: CR14 article-title: Regulation of ornithine decarboxylase publication-title: J. Biol. Chem. doi: 10.1074/jbc.R500031200 contributor: fullname: Pegg – volume: 78 start-page: 2869 year: 1981 end-page: 2873 ident: CR22 article-title: Identification of hypusine, an unusual amino acid, in a protein from human lymphocytes and of spermidine as its biosynthetic precursor publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.78.5.2869 contributor: fullname: Folk – volume: 368 start-page: eaaw5473 year: 2020 ident: CR3 article-title: Metabolic reprogramming and cancer progression publication-title: Science doi: 10.1126/science.aaw5473 contributor: fullname: De Berardinis – volume: 22 start-page: 1962 year: 2008 end-page: 1971 ident: CR17 article-title: TEAD mediates YAP-dependent gene induction and growth control publication-title: Genes Dev. doi: 10.1101/gad.1664408 contributor: fullname: Zhao – volume: 17 start-page: 1218 year: 2015 end-page: 1227 ident: CR53 article-title: Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth publication-title: Nat. Cell Biol. doi: 10.1038/ncb3216 contributor: fullname: Zanconato – volume: 23 start-page: 27 year: 2016 end-page: 47 ident: CR1 article-title: The emerging hallmarks of cancer metabolism publication-title: Cell Metab. doi: 10.1016/j.cmet.2015.12.006 contributor: fullname: Thompson – volume: 119 start-page: 941 year: 2004 end-page: 953 ident: CR30 article-title: Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 publication-title: Cell doi: 10.1016/j.cell.2004.12.012 contributor: fullname: Shi – volume: 284 start-page: 13355 year: 2009 end-page: 13362 ident: CR33 article-title: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition publication-title: J. Biol. Chem. doi: 10.1074/jbc.M900843200 contributor: fullname: Zhang – volume: 41 start-page: 1037 year: 2020 end-page: 1050 ident: CR44 article-title: Polyamines and kynurenines at the intersection of immune modulation publication-title: Trends Immunol. doi: 10.1016/j.it.2020.09.007 contributor: fullname: Mondanelli – volume: 29 start-page: 783 year: 2016 end-page: 803 ident: CR6 article-title: YAP/TAZ at the roots of cancer publication-title: Cancer Cell doi: 10.1016/j.ccell.2016.05.005 contributor: fullname: Piccolo – volume: 50 start-page: 264 year: 2019 end-page: 282 ident: CR7 article-title: The Hippo signaling pathway in development and disease publication-title: Dev. Cell doi: 10.1016/j.devcel.2019.06.003 contributor: fullname: Pan – volume: 28 start-page: 196 year: 2018 end-page: 206 ident: CR10 article-title: Interplay between YAP/TAZ and metabolism publication-title: Cell Metab. doi: 10.1016/j.cmet.2018.07.010 contributor: fullname: Guan – volume: 76 start-page: 110 year: 2019 end-page: 125 ident: CR26 article-title: Polyamines control eIF5A hypusination, TFEB translation, and autophagy to reverse B cell senescence publication-title: Mol. Cell doi: 10.1016/j.molcel.2019.08.005 contributor: fullname: Zhang – volume: 15 start-page: 187 year: 2019 end-page: 196 ident: CR48 article-title: Histone methyl-transferases and demethylases in the autophagy regulatory network: the emerging role of KDM1A/LSD1 demethylase publication-title: Autophagy doi: 10.1080/15548627.2018.1520546 contributor: fullname: Majello – volume: 107 start-page: 8248 year: 2010 end-page: 8253 ident: CR15 article-title: The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size and liver tumorigenesis publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0912203107 contributor: fullname: Lee – volume: 268 start-page: 13151 year: 1993 end-page: 13159 ident: CR32 article-title: Features of the spermidine-binding site of deoxyhypusine synthase as derived from inhibition studies. Effective inhibition by bis- and mono-guanylated diamines and polyamines publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)38631-4 contributor: fullname: Folk – volume: 359 start-page: eaan2788 year: 2018 ident: CR47 article-title: Spermidine in health and disease publication-title: Science doi: 10.1126/science.aan2788 contributor: fullname: Kroemer – volume: 130 start-page: 1120 year: 2007 end-page: 1133 ident: CR12 article-title: Elucidation of a universal size-control mechanism in and mammals publication-title: Cell doi: 10.1016/j.cell.2007.07.019 contributor: fullname: Dong – volume: 7 year: 2016 ident: CR43 article-title: LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development publication-title: Nat. Commun. doi: 10.1038/ncomms11961 contributor: fullname: Lee – volume: 51 start-page: 35 year: 2013 end-page: 45 ident: CR25 article-title: eIF5A promotes translation of polyproline motifs publication-title: Mol. Cell doi: 10.1016/j.molcel.2013.04.021 contributor: fullname: Gutierrez – volume: 60 start-page: 328 year: 2015 end-page: 337 ident: CR18 article-title: YAP drives growth by controlling transcriptional pause release from dynamic enhancers publication-title: Mol. Cell doi: 10.1016/j.molcel.2015.09.001 contributor: fullname: Galli – volume: 29 start-page: 492 year: 2018 end-page: 509 ident: CR11 article-title: Hippo signaling: key emerging pathway in cellular and whole-body metabolism publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2018.04.006 contributor: fullname: Maedler – volume: 45 start-page: W98 year: 2017 end-page: W102 ident: CR61 article-title: GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkx247 contributor: fullname: Tang – volume: 18 start-page: 681 year: 2018 end-page: 695 ident: CR13 article-title: Polyamine metabolism and cancer: treatments, challenges and opportunities publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-018-0050-3 contributor: fullname: Pegg – volume: 16 start-page: 472 year: 2016 end-page: 486 ident: CR54 article-title: Cbx8 acts non-canonically with Wdr5 to promote mammary tumorigenesis publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.06.002 contributor: fullname: Chung – volume: 52 start-page: 151 year: 2020 end-page: 160 ident: CR45 article-title: The role of polyamines in the regulation of macrophage polarization and function publication-title: Amino Acids doi: 10.1007/s00726-019-02719-0 contributor: fullname: Wilson – volume: 4 start-page: eaar2606 year: 2018 ident: CR38 article-title: Oil for the cancer engine: the cross-talk between oncogenic signaling and polyamine metabolism publication-title: Sci. Adv. doi: 10.1126/sciadv.aar2606 contributor: fullname: Carracedo – volume: 163 start-page: 811 year: 2015 end-page: 828 ident: CR5 article-title: Hippo pathway in organ size control, tissue homeostasis and cancer publication-title: Cell doi: 10.1016/j.cell.2015.10.044 contributor: fullname: Guan – volume: 168 start-page: 657 year: 2017 end-page: 669 ident: CR4 article-title: Understanding the intersections between metabolism and cancer biology publication-title: Cell doi: 10.1016/j.cell.2016.12.039 contributor: fullname: De Berardinis – volume: 115 start-page: 2353 year: 2018 end-page: 2358 ident: CR52 article-title: Revealing nascent proteomics in signaling pathways and cell differentiation publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1707514115 contributor: fullname: Forester – volume: 17 year: 2016 ident: CR55 article-title: GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler publication-title: Genome Biol. doi: 10.1186/s13059-016-0897-0 contributor: fullname: Takaku – volume: 21 start-page: 2747 year: 2007 end-page: 2761 ident: CR50 article-title: Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control publication-title: Genes Dev. doi: 10.1101/gad.1602907 contributor: fullname: Zhao – volume: 5 start-page: 235 year: 2021 end-page: 257 ident: CR36 article-title: The bidirectional relationship between cancer epigenetics and metabolism publication-title: Annu. Rev. Cancer Biol. doi: 10.1146/annurev-cancerbio-070820-035832 contributor: fullname: Wellen – volume: 11 start-page: 270 year: 2015 end-page: 282 ident: CR41 article-title: Transcriptional co-repressor function of the Hippo pathway transducers YAP and TAZ publication-title: Cell Rep. doi: 10.1016/j.celrep.2015.03.015 contributor: fullname: Lim – volume: 3 start-page: e02564 year: 2014 ident: CR29 article-title: The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6 publication-title: eLife doi: 10.7554/eLife.02564 contributor: fullname: Qing – volume: 16 start-page: 694 year: 2016 end-page: 707 ident: CR34 article-title: Metabolic control of epigenetics in cancer publication-title: Nat. Rev. Cancer doi: 10.1038/nrc.2016.82 contributor: fullname: Michelakis – volume: 107 start-page: 1437 year: 2010 end-page: 1442 ident: CR16 article-title: Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0911427107 contributor: fullname: Lu – volume: 563 start-page: 265 year: 2018 end-page: 269 ident: CR28 article-title: The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ publication-title: Nature doi: 10.1038/s41586-018-0658-1 contributor: fullname: Chang – volume: 68 start-page: e86 year: 2019 ident: CR51 article-title: Using MetaboAnalyst 4.0 for comprehensive and integrative metabolomics data analysis publication-title: Curr. Protoc. Bioinformatics doi: 10.1002/cpbi.86 contributor: fullname: Xia – volume: 261 start-page: 3085 year: 1986 end-page: 3089 ident: CR23 article-title: Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)35750-2 contributor: fullname: Folk – volume: 10 start-page: 254 year: 2010 end-page: 266 ident: CR40 article-title: Translational control in cancer publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2824 contributor: fullname: Schneider – volume: 159 start-page: 1665 year: 2014 end-page: 1680 ident: CR58 article-title: A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping publication-title: Cell doi: 10.1016/j.cell.2014.11.021 contributor: fullname: Rao – volume: 8 start-page: 1103 year: 2016 end-page: 1116 ident: CR31 article-title: LSD1: biologic roles and therapeutic targeting publication-title: Epigenomics doi: 10.2217/epi-2016-0009 contributor: fullname: Somervaille – volume: 54 start-page: 256 year: 2020 end-page: 267 ident: CR9 article-title: Integration of Hippo-YAP signaling with metabolism publication-title: Dev. Cell doi: 10.1016/j.devcel.2020.06.025 contributor: fullname: Irvine – volume: 270 start-page: 8660 year: 1995 end-page: 8666 ident: CR24 article-title: Deoxyhypusine synthase from rat testis: purification and characterization publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.15.8660 contributor: fullname: Park – volume: 518 start-page: 331 year: 2015 end-page: 336 ident: CR57 article-title: Chromatin architecture reorganization during stem cell differentiation publication-title: Nature doi: 10.1038/nature14222 contributor: fullname: Dixon – volume: 474 start-page: 179 year: 2011 end-page: 183 ident: CR19 article-title: Role of YAP/TAZ in mechanotransduction publication-title: Nature doi: 10.1038/nature10137 contributor: fullname: Dupont – volume: 173 start-page: 321 year: 2018 end-page: 337 ident: CR8 article-title: Oncogenic signaling pathways in The Cancer Genome Atlas publication-title: Cell doi: 10.1016/j.cell.2018.03.035 contributor: fullname: Sanchez-Vega – volume: 30 start-page: 2810 year: 2011 end-page: 2822 ident: CR20 article-title: The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene publication-title: Oncogene doi: 10.1038/onc.2011.8 contributor: fullname: Zhang – volume: 547 start-page: 109 year: 2017 end-page: 113 ident: CR39 article-title: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer publication-title: Nature doi: 10.1038/nature22964 contributor: fullname: Zabala-Letona – volume: 462 start-page: 739 year: 2009 end-page: 744 ident: CR2 article-title: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate publication-title: Nature doi: 10.1038/nature08617 contributor: fullname: Dang – volume: 153 start-page: 56 year: 2013 end-page: 69 ident: CR35 article-title: Influence of metabolism on epigenetics and disease publication-title: Cell doi: 10.1016/j.cell.2013.03.004 contributor: fullname: McKnight – volume: 4 start-page: 781 year: 2004 end-page: 792 ident: CR37 article-title: Polyamines and cancer: old molecules, new understanding publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1454 contributor: fullname: Meyskens – volume: 24 start-page: 2383 year: 2010 end-page: 2388 ident: CR49 article-title: The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program publication-title: Genes Dev. doi: 10.1101/gad.1978810 contributor: fullname: Cai – volume: 518 start-page: 350 year: 2015 end-page: 354 ident: CR59 article-title: Integrative analysis of haplotype-resolved epigenomes across human tissues publication-title: Nature doi: 10.1038/nature14217 contributor: fullname: Leung – volume: 47 start-page: W158 year: 2019 end-page: W165 ident: CR56 article-title: WashU Epigenome Browser update 2019 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz348 contributor: fullname: Wang – volume: 267 start-page: 150 year: 1992 end-page: 158 ident: CR21 article-title: Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization of sequences at the inhibitor and coenzyme binding sites publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)48472-4 contributor: fullname: Pegg – volume: 24 start-page: 1599 year: 2018 end-page: 1610 ident: CR27 article-title: Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4 publication-title: Nat. Med. doi: 10.1038/s41591-018-0158-8 contributor: fullname: Zanconato – volume: 174 start-page: 549 year: 2018 end-page: 563 ident: CR46 article-title: LSD1 ablation stimulates anti-tumor immunity and enables checkpoint blockade publication-title: Cell doi: 10.1016/j.cell.2018.05.052 contributor: fullname: Sheng – volume: 36 start-page: 109347 year: 2021 ident: CR42 article-title: Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis publication-title: Cell Rep. doi: 10.1016/j.celrep.2021.109347 contributor: fullname: Hicks-Berthet – volume: 19 year: 2018 ident: CR60 article-title: The 3D Genome Browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions publication-title: Genome Biol. doi: 10.1186/s13059-018-1519-9 contributor: fullname: Wang – volume: 130 start-page: 1120 year: 2007 ident: 848_CR12 publication-title: Cell doi: 10.1016/j.cell.2007.07.019 contributor: fullname: J Dong – volume: 11 start-page: 270 year: 2015 ident: 848_CR41 publication-title: Cell Rep. doi: 10.1016/j.celrep.2015.03.015 contributor: fullname: M Kim – volume: 36 start-page: 109347 year: 2021 ident: 848_CR42 publication-title: Cell Rep. doi: 10.1016/j.celrep.2021.109347 contributor: fullname: J Hicks-Berthet – volume: 518 start-page: 331 year: 2015 ident: 848_CR57 publication-title: Nature doi: 10.1038/nature14222 contributor: fullname: JR Dixon – volume: 45 start-page: W98 year: 2017 ident: 848_CR61 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkx247 contributor: fullname: Z Tang – volume: 474 start-page: 179 year: 2011 ident: 848_CR19 publication-title: Nature doi: 10.1038/nature10137 contributor: fullname: S Dupont – volume: 284 start-page: 13355 year: 2009 ident: 848_CR33 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M900843200 contributor: fullname: H Zhang – volume: 168 start-page: 657 year: 2017 ident: 848_CR4 publication-title: Cell doi: 10.1016/j.cell.2016.12.039 contributor: fullname: MG Van der Heiden – volume: 23 start-page: 27 year: 2016 ident: 848_CR1 publication-title: Cell Metab. doi: 10.1016/j.cmet.2015.12.006 contributor: fullname: NN Pavlova – volume: 115 start-page: 2353 year: 2018 ident: 848_CR52 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1707514115 contributor: fullname: CM Forester – volume: 107 start-page: 8248 year: 2010 ident: 848_CR15 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0912203107 contributor: fullname: KP Lee – volume: 268 start-page: 13151 year: 1993 ident: 848_CR32 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)38631-4 contributor: fullname: J Jakus – volume: 359 start-page: eaan2788 year: 2018 ident: 848_CR47 publication-title: Science doi: 10.1126/science.aan2788 contributor: fullname: F Madeo – volume: 4 start-page: 781 year: 2004 ident: 848_CR37 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1454 contributor: fullname: EW Gerner – volume: 119 start-page: 941 year: 2004 ident: 848_CR30 publication-title: Cell doi: 10.1016/j.cell.2004.12.012 contributor: fullname: Y Shi – volume: 24 start-page: 1599 year: 2018 ident: 848_CR27 publication-title: Nat. Med. doi: 10.1038/s41591-018-0158-8 contributor: fullname: F Zanconato – volume: 4 start-page: eaar2606 year: 2018 ident: 848_CR38 publication-title: Sci. Adv. doi: 10.1126/sciadv.aar2606 contributor: fullname: A Arruabarrena-Aristorena – volume: 51 start-page: 35 year: 2013 ident: 848_CR25 publication-title: Mol. Cell doi: 10.1016/j.molcel.2013.04.021 contributor: fullname: E Gutierrez – volume: 5 start-page: 235 year: 2021 ident: 848_CR36 publication-title: Annu. Rev. Cancer Biol. doi: 10.1146/annurev-cancerbio-070820-035832 contributor: fullname: LT Izzo – volume: 261 start-page: 3085 year: 1986 ident: 848_CR23 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)35750-2 contributor: fullname: A Abbruzzese – volume: 547 start-page: 109 year: 2017 ident: 848_CR39 publication-title: Nature doi: 10.1038/nature22964 contributor: fullname: A Zabala-Letona – volume: 18 start-page: 681 year: 2018 ident: 848_CR13 publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-018-0050-3 contributor: fullname: RA Casero Jr – volume: 462 start-page: 739 year: 2009 ident: 848_CR2 publication-title: Nature doi: 10.1038/nature08617 contributor: fullname: L Dang – volume: 16 start-page: 472 year: 2016 ident: 848_CR54 publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.06.002 contributor: fullname: CY Chung – volume: 159 start-page: 1665 year: 2014 ident: 848_CR58 publication-title: Cell doi: 10.1016/j.cell.2014.11.021 contributor: fullname: SS Rao – volume: 518 start-page: 350 year: 2015 ident: 848_CR59 publication-title: Nature doi: 10.1038/nature14217 contributor: fullname: D Leung – volume: 107 start-page: 1437 year: 2010 ident: 848_CR16 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0911427107 contributor: fullname: L Lu – volume: 8 start-page: 1103 year: 2016 ident: 848_CR31 publication-title: Epigenomics doi: 10.2217/epi-2016-0009 contributor: fullname: A Maiques-Diaz – volume: 29 start-page: 783 year: 2016 ident: 848_CR6 publication-title: Cancer Cell doi: 10.1016/j.ccell.2016.05.005 contributor: fullname: F Zanconato – volume: 19 year: 2018 ident: 848_CR60 publication-title: Genome Biol. doi: 10.1186/s13059-018-1519-9 contributor: fullname: Y Wang – volume: 17 start-page: 1218 year: 2015 ident: 848_CR53 publication-title: Nat. Cell Biol. doi: 10.1038/ncb3216 contributor: fullname: F Zanconato – volume: 153 start-page: 56 year: 2013 ident: 848_CR35 publication-title: Cell doi: 10.1016/j.cell.2013.03.004 contributor: fullname: WG Kaelin – volume: 15 start-page: 187 year: 2019 ident: 848_CR48 publication-title: Autophagy doi: 10.1080/15548627.2018.1520546 contributor: fullname: S Ambrosio – volume: 28 start-page: 196 year: 2018 ident: 848_CR10 publication-title: Cell Metab. doi: 10.1016/j.cmet.2018.07.010 contributor: fullname: JH Koo – volume: 30 start-page: 2810 year: 2011 ident: 848_CR20 publication-title: Oncogene doi: 10.1038/onc.2011.8 contributor: fullname: X Zhang – volume: 16 start-page: 694 year: 2016 ident: 848_CR34 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc.2016.82 contributor: fullname: A Kinnaird – volume: 267 start-page: 150 year: 1992 ident: 848_CR21 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)48472-4 contributor: fullname: R Poulin – volume: 60 start-page: 328 year: 2015 ident: 848_CR18 publication-title: Mol. Cell doi: 10.1016/j.molcel.2015.09.001 contributor: fullname: GG Galli – volume: 41 start-page: 1037 year: 2020 ident: 848_CR44 publication-title: Trends Immunol. doi: 10.1016/j.it.2020.09.007 contributor: fullname: E Proietti – volume: 50 start-page: 264 year: 2019 ident: 848_CR7 publication-title: Dev. Cell doi: 10.1016/j.devcel.2019.06.003 contributor: fullname: Y Zheng – volume: 78 start-page: 2869 year: 1981 ident: 848_CR22 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.78.5.2869 contributor: fullname: MH Park – volume: 281 start-page: 14529 year: 2006 ident: 848_CR14 publication-title: J. Biol. Chem. doi: 10.1074/jbc.R500031200 contributor: fullname: AE Pegg – volume: 22 start-page: 1962 year: 2008 ident: 848_CR17 publication-title: Genes Dev. doi: 10.1101/gad.1664408 contributor: fullname: B Zhao – volume: 173 start-page: 321 year: 2018 ident: 848_CR8 publication-title: Cell doi: 10.1016/j.cell.2018.03.035 contributor: fullname: F Sanchez-Vega – volume: 3 start-page: e02564 year: 2014 ident: 848_CR29 publication-title: eLife doi: 10.7554/eLife.02564 contributor: fullname: Y Qing – volume: 24 start-page: 2383 year: 2010 ident: 848_CR49 publication-title: Genes Dev. doi: 10.1101/gad.1978810 contributor: fullname: J Cai – volume: 163 start-page: 811 year: 2015 ident: 848_CR5 publication-title: Cell doi: 10.1016/j.cell.2015.10.044 contributor: fullname: F-X Yu – volume: 54 start-page: 256 year: 2020 ident: 848_CR9 publication-title: Dev. Cell doi: 10.1016/j.devcel.2020.06.025 contributor: fullname: C Ibar – volume: 21 start-page: 2747 year: 2007 ident: 848_CR50 publication-title: Genes Dev. doi: 10.1101/gad.1602907 contributor: fullname: B Zhao – volume: 174 start-page: 549 year: 2018 ident: 848_CR46 publication-title: Cell doi: 10.1016/j.cell.2018.05.052 contributor: fullname: W Sheng – volume: 52 start-page: 151 year: 2020 ident: 848_CR45 publication-title: Amino Acids doi: 10.1007/s00726-019-02719-0 contributor: fullname: YL Latour – volume: 68 start-page: e86 year: 2019 ident: 848_CR51 publication-title: Curr. Protoc. Bioinformatics doi: 10.1002/cpbi.86 contributor: fullname: J Chong – volume: 368 start-page: eaaw5473 year: 2020 ident: 848_CR3 publication-title: Science doi: 10.1126/science.aaw5473 contributor: fullname: B Faubert – volume: 29 start-page: 492 year: 2018 ident: 848_CR11 publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2018.04.006 contributor: fullname: A Ardestani – volume: 7 year: 2016 ident: 848_CR43 publication-title: Nat. Commun. doi: 10.1038/ncomms11961 contributor: fullname: DH Lee – volume: 10 start-page: 254 year: 2010 ident: 848_CR40 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2824 contributor: fullname: D Silvera – volume: 47 start-page: W158 year: 2019 ident: 848_CR56 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz348 contributor: fullname: D Li – volume: 270 start-page: 8660 year: 1995 ident: 848_CR24 publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.15.8660 contributor: fullname: EC Wolff – volume: 17 year: 2016 ident: 848_CR55 publication-title: Genome Biol. doi: 10.1186/s13059-016-0897-0 contributor: fullname: M Takaku – volume: 76 start-page: 110 year: 2019 ident: 848_CR26 publication-title: Mol. Cell doi: 10.1016/j.molcel.2019.08.005 contributor: fullname: H Zhang – volume: 563 start-page: 265 year: 2018 ident: 848_CR28 publication-title: Nature doi: 10.1038/s41586-018-0658-1 contributor: fullname: L Chang |
SSID | ssj0014407 |
Score | 2.5875154 |
Snippet | Metabolic reprogramming is central to oncogene-induced tumorigenesis by providing the necessary building blocks and energy sources, but how oncogenic... Metabolic reprogramming is central to oncogene-induced tumorigenesis by providing the necessary building blocks and energy sources, but how oncogenic signaling... |
SourceID | pubmedcentral proquest crossref pubmed springer |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 373 |
SubjectTerms | 13/106 13/109 13/51 14/63 38/1 38/77 38/91 42 631/67/68/2486 631/80/86 692/699/67 692/699/67/2327 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Biomedical and Life Sciences Biosynthesis Cancer Research Carcinogenesis - genetics Cell Biology Cell growth Cell proliferation Cell Proliferation - genetics Developmental Biology Energy sources Epigenetics Gene expression Genes Histone Demethylases - genetics Histone Demethylases - metabolism Histones Humans Life Sciences Metabolism Metabolites Neoplasms - genetics Neoplasms - pathology Ornithine decarboxylase Phosphoproteins - genetics Phosphoproteins - metabolism Polyamines Stem Cells Suppressors Trans-Activators - metabolism Transcription Translation Tumorigenesis Tumors YAP-Signaling Proteins Yes-associated protein |
Title | YAP/TAZ drives cell proliferation and tumour growth via a polyamine–eIF5A hypusination–LSD1 axis |
URI | https://link.springer.com/article/10.1038/s41556-022-00848-5 https://www.ncbi.nlm.nih.gov/pubmed/35177822 https://www.proquest.com/docview/2639130812 https://search.proquest.com/docview/2630919057 https://pubmed.ncbi.nlm.nih.gov/PMC8930503 |
Volume | 24 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1fb9MwED-xVUi8IP4vMCoj8QZWEyeOkyeUjlUDQTXBJhVeIjt2aCVIQ5si-sZ32DfcJ9nZSTuVCV5jR4nv7LuffeffAbzUXBdJkQoqNBc0isuIpqGKKY_LUiUpEyqw950_juOT8-j9hE-6A7dll1a5sYnOUOt5Yc_IBwxdKdpb9Edv6p_UVo2y0dWuhMYe9FgQ2TBtb3g8Pv20jSNEkbswjeaAU4FQoLs244fJYGldqU3AZdSRylO-65pu4M2baZN_xU6dSxrdg7sdliRZq_z7cMtUD-B2W11y_RD0l-x0cJZ9JXphuWWJPaMnta3SU5pW70RWmjQr3P0vyDfcjzdT8msmiST1_Pta_kAAevnnwrwb8YxM17VNkXev4cMPn98GRP6eLR_B-ej47OiEdkUVaBGJqKGIQIwSzNIqBwniL6W0JV0TUvpM8RB3ykUaF1IYoYUvGe6GAp3qsORGs1AxP3wM-9W8MgdALNldEKRF4ScForJAGZWoJCqlQpiQlsKDVxt55nXLnZG7mHeY5K30c5R-7qSfcw8ONyLPu3W0zK-17sGLbTOuACsyWZn5yvVB0JMi8PTgSauh7edCHgiLgTwQO7rbdrDs2rst1WzqWLYRyFmuHA9eb7R8_Vv_HsXT_4_iGdxhbsbZJLZD2G8WK_McUU2j-rAnJqIPvWw0HI773US-AkO098A |
link.rule.ids | 230,315,786,790,891,12083,21416,27955,27956,31752,31753,33777,33778,43343,43838,74100,74657 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NjtMwEB7BIgQXxO8SWMBI3MBqEsdxckIVUHWhu0KiKxUukR07tBKkpU0RvfEOvCFPwoyTdlVWcI0dJZmZeL7xjL8BeGalLbMyV1xZqXiSVgnPhUm5TKvKZHmsTETnnU9O0-FZ8nYiJ92G26orq9yuiX6htvOS9sh7MbpSXG_RH71cfOPUNYqyq10LjctwJREiITtXk13ARXlL1Z4uklwhEOgOzYQi663IkVL5bcw9pTyX-47pAtq8WDT5V-bUO6TBTbjRIUnWb1V_Cy65-jZcbXtLbu6A_dh_3xv3PzG7JGZZRjv0bEE9eirXap3p2rJmjbH_kn3GaLyZsu8zzTRbzL9s9FeEn79__nLHA9ln082CCuT9bXhx9OF1xPSP2eounA3ejF8NeddSgZeJShqO-MMZFROpcpQh-jLGEuWa0jqMjRQYJ5d5WmrllFWhjjEWimxuRSWdjYWJQ3EPDup57e4DI6q7KMrLMsxKxGSRcSYzWVJpgyAhr1QAz7fyLBYtc0bhM94iK1rpFyj9wku_kAEcbUVedH_RqjjXeQBPd8No_yQyXbv52s9ByJMj7AzgsNXQ7nFCRooQUABqT3e7CcStvT9Sz6aeYxthHDHlBPBiq-Xz1_r3Vzz4_1c8gWvD8cmoGB2fvnsI12NvfVTOdgQHzXLtHiG-acxjb8R_AEp59uQ |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB5BEYgL4llSChiJG1ibl-PkhFaUVQulqkQrLVwiv8KuRLNpN4vYG_-Bf8gvYcbJbrVUcI3z8njs-cYz_gbgpRXW5KaQXFoheZpVKS8SnXGRVZXOi1jqiM47fzzK9k_T92Mx7vOf5n1a5WpN9Au1nRnaIx_EaEpxvUV7NKj6tIjjvdGb5pxTBSmKtPblNK7DDbSSIZVxkOO180UxTNmdNBJcIijoD9CEST6Yk1GlVNyYe3p5LjaN1BXkeTWB8q8oqjdOo7twp0eVbNipwT245ur7cLOrM7l8APbz8HhwMvzC7AWxzDLarWcN1eupXKcBTNWWtYszfBH7ip55O2Hfp4op1sy-LdUZQtHfP3-5g5EYssmyoWR5_xhePPy0FzH1Yzp_CKejdydv93lfXoGbVKYtRyzitIyJYDnKEYlpbYl-TSoVxlok6DObIjNKOmllqGL0iyJb2KQSzsaJjsPkEWzVs9o9Bka0d1FUGBPmBvFZpJ3OdZ5WSiNgKCoZwKuVPMumY9EoffQ7yctO-iVKv_TSL0UAuyuRl_2MmpeX4x_Ai3UzzgUSmardbOHvQfhTIAQNYLsbofXnEhFJQkMByI2xW99APNubLfV04vm2EdIRa04Ar1ejfPlb_-7Fzv978Rxuof6WhwdHH57A7dgrH2W27cJWe7FwTxHqtPqZ1-E_1wL7EA |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=YAP%2FTAZ+drives+cell+proliferation+and+tumour+growth+via+a+polyamine-eIF5A+hypusination-LSD1+axis&rft.jtitle=Nature+cell+biology&rft.au=Li%2C+Hongde&rft.au=Wu%2C+Bo-Kuan&rft.au=Kanchwala%2C+Mohammed&rft.au=Cai%2C+Jing&rft.date=2022-03-01&rft.eissn=1476-4679&rft.volume=24&rft.issue=3&rft.spage=373&rft.epage=383&rft_id=info:doi/10.1038%2Fs41556-022-00848-5&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1465-7392&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1465-7392&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1465-7392&client=summon |