Diversity in Hapten Recognition: Structural Study of an Anti-cocaine Antibody M82G2

Antibodies against cocaine and other drugs of abuse are the basis for diagnostic tests for the presence of those drugs in human serum. The 1.7 Å resolution crystal structure of the anti-cocaine monoclonal antibody M82G2 in complex with cocaine is presented. This structure determination was undertake...

Full description

Saved in:
Bibliographic Details
Published inJournal of crystal growth Vol. 349; no. 3; pp. 570 - 582
Main Authors Pozharski, Edwin, Moulin, Aaron, Hewagama, Anura, Shanafelt, Armen B., Petsko, Gregory A., Ringe, Dagmar
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 10.06.2005
Subjects
60 APPLIED LIFE SCIENCES
Amino Acid Sequence
Animals
ANTIBODIES
antibody engineering
antibody structure
COCAINE
Cocaine - analysis
Cocaine - blood
Cocaine - immunology
CRYSTAL GROWTH
Hydrogen Bonding
Immunoglobulin Fab Fragments - chemistry
Immunoglobulin Fab Fragments - genetics
Immunoglobulin Fab Fragments - immunology
immunotherapy
Ligands
Mice
Molecular Sequence Data
national synchrotron light source
Protein Binding - immunology
Protein Structure, Tertiary
protein–ligand interaction
Static Electricity
Structural Homology, Protein
antibody engineering
CDR
cocaine
antibody structure
protein–ligand interaction
immunotherapy
Online AccessGet full text

Cover

Abstract Antibodies against cocaine and other drugs of abuse are the basis for diagnostic tests for the presence of those drugs in human serum. The 1.7 Å resolution crystal structure of the anti-cocaine monoclonal antibody M82G2 in complex with cocaine is presented. This structure determination was undertaken to establish the stereochemical features in the antibody binding site that confer specificity for cocaine, and as part of an ongoing project to understand the rules that govern molecular recognition. The cocaine-binding site can be characterized topologically as a narrow groove on the protein surface. The antibody utilizes water-mediated hydrogen bonding, and cation–π and stacking (π–π) interactions to provide specificity. Comparison with the previously published structure of the anti-cocaine antibody GNC92H2 shows that binding of a small ligand can be achieved in diverse ways, both in terms of a binding site structure/topology and protein–ligand interactions.
AbstractList Antibodies against cocaine and other drugs of abuse are the basis for diagnostic tests for the presence of those drugs in human serum. The 1.7 Å resolution crystal structure of the anti-cocaine monoclonal antibody M82G2 in complex with cocaine is presented. This structure determination was undertaken to establish the stereochemical features in the antibody binding site that confer specificity for cocaine, and as part of an ongoing project to understand the rules that govern molecular recognition. The cocaine-binding site can be characterized topologically as a narrow groove on the protein surface. The antibody utilizes water-mediated hydrogen bonding, and cation–π and stacking (π–π) interactions to provide specificity. Comparison with the previously published structure of the anti-cocaine antibody GNC92H2 shows that binding of a small ligand can be achieved in diverse ways, both in terms of a binding site structure/topology and protein–ligand interactions.
Antibodies against cocaine and other drugs of abuse are the basis for diagnostic tests for the presence of those drugs in human serum. The 1.7A resolution crystal structure of the anti-cocaine monoclonal antibody M82G2 in complex with cocaine is presented. This structure determination was undertaken to establish the stereochemical features in the antibody binding site that confer specificity for cocaine, and as part of an ongoing project to understand the rules that govern molecular recognition. The cocaine-binding site can be characterized topologically as a narrow groove on the protein surface. The antibody utilizes water-mediated hydrogen bonding, and cation-pi and stacking (pi-pi) interactions to provide specificity. Comparison with the previously published structure of the anti-cocaine antibody GNC92H2 shows that binding of a small ligand can be achieved in diverse ways, both in terms of a binding site structure/topology and protein-ligand interactions.
Author Shanafelt, Armen B.
Moulin, Aaron
Pozharski, Edwin
Hewagama, Anura
Petsko, Gregory A.
Ringe, Dagmar
Author_xml – sequence: 1
  givenname: Edwin
  surname: Pozharski
  fullname: Pozharski, Edwin
  organization: Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street, Waltham, MA 02454, USA
– sequence: 2
  givenname: Aaron
  surname: Moulin
  fullname: Moulin, Aaron
  organization: Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street, Waltham, MA 02454, USA
– sequence: 3
  givenname: Anura
  surname: Hewagama
  fullname: Hewagama, Anura
  organization: Roche Diagnostics Corporation, 9115 Hague Road, Indianapolis, IN 46250, USA
– sequence: 4
  givenname: Armen B.
  surname: Shanafelt
  fullname: Shanafelt, Armen B.
  organization: Roche Diagnostics Corporation, 9115 Hague Road, Indianapolis, IN 46250, USA
– sequence: 5
  givenname: Gregory A.
  surname: Petsko
  fullname: Petsko, Gregory A.
  organization: Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street, Waltham, MA 02454, USA
– sequence: 6
  givenname: Dagmar
  surname: Ringe
  fullname: Ringe, Dagmar
  email: ringe@brandeis.edu
  organization: Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street, Waltham, MA 02454, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/15885702$$D View this record in MEDLINE/PubMed
https://www.osti.gov/biblio/884093$$D View this record in Osti.gov
BookMark eNqFkU1v1DAQhi1URLeFH8AFhUtvCWM7Hw6cqgItUqtKtD1bzmQCXu3ai-1U2n-Pw67EDU4zIz_zSuPnjJ0474ixtxwqDrz9sK7W26ESAE0FsgIFL9iKg-pL1Up1wlYAQpRCyfaUncW4hgzKWr1ip7xRqulArNjDZ_tMIdq0L6wrbswukSu-E_ofzibr3cfiIYUZ0xzMJrfzuC_8VBhXXLpkS_RorKM_w-Dz250S1-I1ezmZTaQ3x3rOnr5-eby6KW_vr79dXd6WWHd1KhuaeqGAS9NiYxD73AkxYQdG8mmoDdVKYkdyxBr7DAz92AzYkEAgPkl5zt4fcn1MVke0ifAneucIk1aqhn5hLg7MLvhfM8WktzYibTbGkZ-jbjslBef8vyDvGpCtUhnkBxCDjzHQpHfBbk3Yaw560aLXOmvRixYNUmcteefdMXwetjT-3Th6yMCnA0D5v54theUcckijDcs1o7f_iP8Nuumeow
CitedBy_id crossref_primary_10_1097_FTD_0b013e31819c1b83
crossref_primary_10_1021_ac902706t
crossref_primary_10_1038_srep04640
crossref_primary_10_1021_acs_analchem_0c02286
crossref_primary_10_3109_15563650_2013_768344
crossref_primary_10_1373_clinchem_2008_118638
crossref_primary_10_1016_j_jmb_2011_02_061
crossref_primary_10_1021_cr300222d
crossref_primary_10_1080_19420862_2023_2215363
crossref_primary_10_1016_j_str_2005_10_014
crossref_primary_10_1089_mab_2022_0025
crossref_primary_10_1021_ja077972s
crossref_primary_10_1021_acs_analchem_8b05174
crossref_primary_10_1039_b9nr00059c
crossref_primary_10_1016_j_jmb_2011_10_042
crossref_primary_10_1107_S0907444910027927
crossref_primary_10_1002_cphc_201700452
crossref_primary_10_1186_1471_227X_9_5
crossref_primary_10_1016_j_ejmech_2010_02_004
crossref_primary_10_1073_pnas_0906153106
crossref_primary_10_1002_jmr_2845
crossref_primary_10_1107_S2053230X19013608
crossref_primary_10_1002_pro_244
crossref_primary_10_1194_jlr_M075614
crossref_primary_10_1021_jacsau_3c00781
crossref_primary_10_1016_j_aca_2013_02_027
crossref_primary_10_1088_1674_1056_acd687
crossref_primary_10_1016_j_tet_2010_11_054
Cites_doi 10.1006/jmbi.2000.4083
10.1038/38470
10.1006/jmbi.1994.1133
10.1073/pnas.90.16.7711
10.1021/ja00098a035
10.1002/jcc.10061
10.1385/CBB:35:1:63
10.1006/jmbi.1997.1354
10.1073/pnas.96.17.9459
10.1016/0010-4655(95)00042-E
10.1007/s008940100045
10.1073/pnas.71.8.2925
10.1016/0022-2836(87)90412-8
10.1093/nar/28.1.235
10.1073/pnas.84.22.8075
10.1006/jmbi.1997.1442
10.1126/science.2333521
10.1016/S0076-6879(97)76066-X
10.1016/S0022-1759(01)00325-8
10.1126/science.8456315
10.1093/nar/29.1.205
10.1107/S0365110X6300205X
10.1002/prot.10116
10.1126/science.2426778
10.1016/j.jmb.2003.12.084
10.1107/S0021889803006721
10.1073/pnas.86.15.5938
10.1016/0022-2836(94)90046-9
10.1073/pnas.91.14.6423
10.1110/ps.0209102
10.1038/378727a0
10.1021/bi961419y
10.1006/jmbi.2001.4839
10.1084/jem.132.2.211
10.1021/bi9924314
10.1074/jbc.273.44.28576
10.1002/prot.1106
10.1107/S0108767393007597
10.1073/pnas.93.1.7
10.1002/prot.340110407
10.1073/pnas.97.11.6202
ContentType Journal Article
Copyright 2005
Copyright_xml – notice: 2005
CorporateAuthor Brookhaven National Laboratory (BNL) National Synchrotron Light Source (NSLS)
CorporateAuthor_xml – name: Brookhaven National Laboratory (BNL) National Synchrotron Light Source (NSLS)
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QO
8FD
FR3
P64
7X8
OTOTI
DOI 10.1016/j.jmb.2005.03.080
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Biotechnology Research Abstracts
Technology Research Database
Engineering Research Database
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
OSTI.GOV
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Engineering Research Database
Biotechnology Research Abstracts
Technology Research Database
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
Engineering Research Database
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
Biology
Engineering
EISSN 1089-8638
1873-5002
EndPage 582
ExternalDocumentID 884093
10_1016_j_jmb_2005_03_080
15885702
S0022283605003815
Genre Research Support, U.S. Gov't, P.H.S
Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIGMS NIH HHS
  grantid: GM26788
GroupedDBID ---
--K
--M
-DZ
-ET
-~X
.55
.GJ
.~1
0R~
186
1B1
1RT
1~.
1~5
29L
3O-
4.4
457
4G.
53G
5GY
5RE
5VS
7-5
71M
85S
8P~
9JM
AAAJQ
AABNK
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AARKO
AAXUO
ABEFU
ABFNM
ABFRF
ABGSF
ABJNI
ABLJU
ABMAC
ABOCM
ABPPZ
ABUDA
ABXDB
ABYKQ
ACDAQ
ACGFO
ACGFS
ACKIV
ACNCT
ACRLP
ADBBV
ADEZE
ADFGL
ADIYS
ADMUD
ADUVX
AEBSH
AEFWE
AEHWI
AEKER
AENEX
AFFNX
AFKWA
AFMIJ
AFTJW
AFXIZ
AGEKW
AGHFR
AGRDE
AGUBO
AGYEJ
AHHHB
AHPSJ
AI.
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
CAG
CJTIS
COF
CS3
DM4
DOVZS
DU5
EBS
EFBJH
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
G8K
GBLVA
GX1
HLW
HMG
HVGLF
HX~
HZ~
H~9
IH2
IHE
J1W
K-O
KOM
LG5
LUGTX
LX2
LZ5
M41
MO0
MVM
N9A
NEJ
O-L
O9-
OAUVE
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
RNS
ROL
RPZ
SBG
SDF
SDG
SDP
SES
SEW
SIN
SPCBC
SSI
SSU
SSZ
T5K
TWZ
UQL
VH1
VQA
WH7
WUQ
X7M
XJT
XOL
XPP
Y6R
YQT
YYP
ZGI
ZKB
ZMT
ZU3
~G-
~KM
AAHBH
AAXKI
ADVLN
AKRWK
CGR
CUY
CVF
ECM
EIF
NPM
0SF
AAYXX
AFJKZ
CITATION
7QO
8FD
FR3
P64
7X8
9JN
AALMO
ABNEU
ABPIF
ABPTK
ACFVG
ACIWK
ACNNM
AIVDX
EFJIC
M24
M38
OGIMB
OTOTI
SPC
SPD
SSQ
TN5
~02
ID FETCH-LOGICAL-c474t-5ef928013a6c5acc913a22fc70a31fb4ae483c7e3dc4c9accb9d5bc5e2c0e1f33
IEDL.DBID AIKHN
ISSN 0022-2836
0022-0248
IngestDate Thu May 18 18:19:53 EDT 2023
Sat Aug 17 03:59:43 EDT 2024
Fri Aug 16 01:42:45 EDT 2024
Thu Sep 26 16:16:30 EDT 2024
Sat Sep 28 07:43:44 EDT 2024
Fri Feb 23 02:33:49 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords antibody engineering
CDR
cocaine
antibody structure
protein–ligand interaction
immunotherapy
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c474t-5ef928013a6c5acc913a22fc70a31fb4ae483c7e3dc4c9accb9d5bc5e2c0e1f33
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
DOE/OFFICE OF SCIENCE
BNL-76428-2005-JA
DE-AC02-98CH10886
PMID 15885702
PQID 17503688
PQPubID 23462
PageCount 13
ParticipantIDs osti_scitechconnect_884093
proquest_miscellaneous_67832111
proquest_miscellaneous_17503688
crossref_primary_10_1016_j_jmb_2005_03_080
pubmed_primary_15885702
elsevier_sciencedirect_doi_10_1016_j_jmb_2005_03_080
PublicationCentury 2000
PublicationDate 2005-06-10
PublicationDateYYYYMMDD 2005-06-10
PublicationDate_xml – month: 06
  year: 2005
  text: 2005-06-10
  day: 10
PublicationDecade 2000
PublicationPlace England
PublicationPlace_xml – name: England
– name: United States
PublicationTitle Journal of crystal growth
PublicationTitleAlternate J Mol Biol
PublicationYear 2005
Publisher Elsevier Ltd
Publisher_xml – name: Elsevier Ltd
References Berendsen, van der Spoel, van Drunen (bib38) 1995; 91
Yang, Wright, Eldefrawi, Pou, MacKerell (bib35) 1994; 116
Landry, Zhao, Yang, Glickman, Georgiadis (bib4) 1993; 259
Larsen, Zhou, Heine, Wirsching, Janda, Wilson (bib13) 2001; 311
Tsodikov, Record, Sergeev (bib40) 2002; 23
Al-Lazikani, Lesk, Chothia (bib18) 1997; 273
Padlan, Silverton, Sheriff, Cohen, Smith-Gill, Davies (bib9) 1989; 86
Carrera, Ashley, Parsons, Wirsching, Koob, Janda (bib5) 1995; 378
Ulrich, Mundorff, Santarsiero, Driggers, Stevens, Schultz (bib25) 1997; 389
Nicholls, Sharp, Honig (bib41) 1991; 11
Braden, Souchon, Eisele, Bentley, Bhat, Navaza, Poljak (bib11) 1994; 243
Gallivan, Dougherty (bib29) 1999; 96
Zdanov, Li, Bundle, Deng, MacKenzie, Narang (bib19) 1994; 91
Morea, Tramontano, Rustici, Chothia, Lesk (bib20) 1998; 275
Kleywegt (bib36) 1995; 31
Fenn, Ringe, Petsko (bib42) 2003; 36
Mundorff, Hanson, Varvak, Ulrich, Schulz, Stevens (bib26) 2000; 39
Lindahl, Hess, van der Spoel (bib39) 2001; 7
Sheriff, Silverton, Padlan, Cohen, Smith-Gill, Finzel, Davies (bib8) 1987; 84
Wu, Kabat (bib16) 1970; 132
Johnson, Wu (bib37) 2001; 29
Gabe, Barnes (bib43) 1963; 16
Reynolds, Gilbert, Tanford (bib22) 1974; 71
Cahill (bib2) 2001; 250
Stanfield, Fieser, Lerner, Wilson (bib21) 1990; 248
Pozharski, Wilson, Hewagama, Shanafelt, Petsko, Ringe (bib28) 2004; 337
Navaza (bib33) 1994; 50
Lim, Owens, Arnold, Sacchettini, Linthicum (bib27) 1998; 273
Davies, Cohen (bib6) 1996; 93
Chothia, Lesk (bib17) 1987; 196
Berman, Westbrook, Feng, Gilliland, Bhat, Weissig (bib23) 2000; 28
Gervasio, Chelli, Procacci, Schettino (bib30) 2002; 48
Pons, Stratton, Kirsch (bib12) 2002; 11
Brunger, Adams, Clore, DeLano, Gros, Grosse-Kunstleve (bib34) 1998; D54
Otwinowski, Minor (bib32) 1997; 276
Wentworth, Janda (bib1) 2001; 35
Guddat, Shan, Anchin, Linthicum, Edmundson (bib14) 1994; 236
Schutz, Warshel (bib31) 2001; 44
Carrera, Ashley, Zhou, Wirsching, Koob, Janda (bib3) 2000; 97
Chitarra, Alzari, Bentley, Bhat, Eisele, Houdusse (bib10) 1993; 90
England, Bregegere, Bedouelle (bib24) 1997; 36
Amit, Mariuzza, Phillips, Poljak (bib7) 1986; 233
Guddat, Shan, Broomell, Ramsland, Fan, Anchin (bib15) 2000; 302
Kleywegt (10.1016/j.jmb.2005.03.080_bib36) 1995; 31
Carrera (10.1016/j.jmb.2005.03.080_bib5) 1995; 378
Fenn (10.1016/j.jmb.2005.03.080_bib42) 2003; 36
Wentworth (10.1016/j.jmb.2005.03.080_bib1) 2001; 35
Padlan (10.1016/j.jmb.2005.03.080_bib9) 1989; 86
Chothia (10.1016/j.jmb.2005.03.080_bib17) 1987; 196
Lim (10.1016/j.jmb.2005.03.080_bib27) 1998; 273
Gervasio (10.1016/j.jmb.2005.03.080_bib30) 2002; 48
Al-Lazikani (10.1016/j.jmb.2005.03.080_bib18) 1997; 273
Sheriff (10.1016/j.jmb.2005.03.080_bib8) 1987; 84
Larsen (10.1016/j.jmb.2005.03.080_bib13) 2001; 311
Chitarra (10.1016/j.jmb.2005.03.080_bib10) 1993; 90
England (10.1016/j.jmb.2005.03.080_bib24) 1997; 36
Tsodikov (10.1016/j.jmb.2005.03.080_bib40) 2002; 23
Johnson (10.1016/j.jmb.2005.03.080_bib37) 2001; 29
Braden (10.1016/j.jmb.2005.03.080_bib11) 1994; 243
Berman (10.1016/j.jmb.2005.03.080_bib23) 2000; 28
Landry (10.1016/j.jmb.2005.03.080_bib4) 1993; 259
Pozharski (10.1016/j.jmb.2005.03.080_bib28) 2004; 337
Davies (10.1016/j.jmb.2005.03.080_bib6) 1996; 93
Guddat (10.1016/j.jmb.2005.03.080_bib14) 1994; 236
Yang (10.1016/j.jmb.2005.03.080_bib35) 1994; 116
Gallivan (10.1016/j.jmb.2005.03.080_bib29) 1999; 96
Guddat (10.1016/j.jmb.2005.03.080_bib15) 2000; 302
Reynolds (10.1016/j.jmb.2005.03.080_bib22) 1974; 71
Berendsen (10.1016/j.jmb.2005.03.080_bib38) 1995; 91
Nicholls (10.1016/j.jmb.2005.03.080_bib41) 1991; 11
Amit (10.1016/j.jmb.2005.03.080_bib7) 1986; 233
Ulrich (10.1016/j.jmb.2005.03.080_bib25) 1997; 389
Carrera (10.1016/j.jmb.2005.03.080_bib3) 2000; 97
Wu (10.1016/j.jmb.2005.03.080_bib16) 1970; 132
Brunger (10.1016/j.jmb.2005.03.080_bib34) 1998; D54
Stanfield (10.1016/j.jmb.2005.03.080_bib21) 1990; 248
Schutz (10.1016/j.jmb.2005.03.080_bib31) 2001; 44
Gabe (10.1016/j.jmb.2005.03.080_bib43) 1963; 16
Pons (10.1016/j.jmb.2005.03.080_bib12) 2002; 11
Morea (10.1016/j.jmb.2005.03.080_bib20) 1998; 275
Lindahl (10.1016/j.jmb.2005.03.080_bib39) 2001; 7
Mundorff (10.1016/j.jmb.2005.03.080_bib26) 2000; 39
Zdanov (10.1016/j.jmb.2005.03.080_bib19) 1994; 91
Cahill (10.1016/j.jmb.2005.03.080_bib2) 2001; 250
Otwinowski (10.1016/j.jmb.2005.03.080_bib32) 1997; 276
Navaza (10.1016/j.jmb.2005.03.080_bib33) 1994; 50
References_xml – volume: 243
  start-page: 767
  year: 1994
  end-page: 781
  ident: bib11
  article-title: 3-Dimensional structures of the free and the antigen-complexed Fab from monoclonal antilysozyme antibody-D44.1
  publication-title: J. Mol. Biol.
  contributor:
    fullname: Poljak
– volume: 39
  start-page: 627
  year: 2000
  end-page: 632
  ident: bib26
  article-title: Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement
  publication-title: Biochemistry
  contributor:
    fullname: Stevens
– volume: 273
  start-page: 28576
  year: 1998
  end-page: 28582
  ident: bib27
  article-title: Crystal structure of monoclonal 6B5 fab complexed with phencyclidine
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Linthicum
– volume: 276
  start-page: 307
  year: 1997
  end-page: 326
  ident: bib32
  article-title: Processing of X-ray diffraction data collected in oscillation mode
  publication-title: Methods Enzymol.
  contributor:
    fullname: Minor
– volume: 23
  start-page: 600
  year: 2002
  end-page: 609
  ident: bib40
  article-title: A novel computer program for fast and exact calculation of accessible and molecular surface areas and average surface curvature
  publication-title: J. Comp. Chem.
  contributor:
    fullname: Sergeev
– volume: 11
  start-page: 281
  year: 1991
  end-page: 296
  ident: bib41
  article-title: Protein folding and association - insights from the interfacial and thermodynamic properties of hydrocarbons
  publication-title: Proteins: Struct. Funct. Genet.
  contributor:
    fullname: Honig
– volume: 132
  start-page: 211
  year: 1970
  end-page: 250
  ident: bib16
  article-title: An analysis of sequences of variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity
  publication-title: J. Exp. Med.
  contributor:
    fullname: Kabat
– volume: 28
  start-page: 235
  year: 2000
  end-page: 242
  ident: bib23
  article-title: The Protein Data Bank
  publication-title: Nucl. Acids Res.
  contributor:
    fullname: Weissig
– volume: D54
  start-page: 905
  year: 1998
  end-page: 921
  ident: bib34
  article-title: Crystallography and NMR system (CNS): a new software system for macromolecular structure determination
  publication-title: Acta Crystallog.
  contributor:
    fullname: Grosse-Kunstleve
– volume: 302
  start-page: 853
  year: 2000
  end-page: 872
  ident: bib15
  article-title: The three-dimensional structure of a complex of a murine Fab (NC10.14) with a potent sweetener (NC174): an illustration of structural diversity in antigen recognition by immunoglobulins
  publication-title: J. Mol. Biol.
  contributor:
    fullname: Anchin
– volume: 50
  start-page: 157
  year: 1994
  end-page: 163
  ident: bib33
  article-title: AMoRe: an automated package for molecular replacement
  publication-title: Acta Crystallog. sect. A
  contributor:
    fullname: Navaza
– volume: 233
  start-page: 747
  year: 1986
  end-page: 753
  ident: bib7
  article-title: 3-Dimensional structure of an antigen-antibody complex at 2.8-Å resolution
  publication-title: Science
  contributor:
    fullname: Poljak
– volume: 36
  start-page: 944
  year: 2003
  end-page: 947
  ident: bib42
  article-title: POVScript+: a program for model and data visualization using persistence of vision ray-tracing
  publication-title: J. Appl. Crystallog.
  contributor:
    fullname: Petsko
– volume: 36
  start-page: 164
  year: 1997
  end-page: 172
  ident: bib24
  article-title: Energetic and kinetic contributions of contact residues of antibody D1.3 in the interaction with lysozyme
  publication-title: Biochemistry
  contributor:
    fullname: Bedouelle
– volume: 44
  start-page: 400
  year: 2001
  end-page: 417
  ident: bib31
  article-title: What axe the dielectric “constants” of proteins and how to validate electrostatic models?
  publication-title: Proteins: Struct. Funct. Genet.
  contributor:
    fullname: Warshel
– volume: 389
  start-page: 271
  year: 1997
  end-page: 275
  ident: bib25
  article-title: The interplay between binding energy and catalysis in the evolution of a catalytic antibody
  publication-title: Nature
  contributor:
    fullname: Schultz
– volume: 250
  start-page: 81
  year: 2001
  end-page: 91
  ident: bib2
  article-title: Protein and antibody arrays and their medical applications
  publication-title: J. Immunol. Methods
  contributor:
    fullname: Cahill
– volume: 93
  start-page: 7
  year: 1996
  end-page: 12
  ident: bib6
  article-title: Interactions of protein antigens with antibodies
  publication-title: Proc. Natl Acad. Sci. USA
  contributor:
    fullname: Cohen
– volume: 337
  start-page: 691
  year: 2004
  end-page: 697
  ident: bib28
  article-title: Anchoring a cationic ligand: the structure of the Fab fragment of the anti-morphine antibody 9B1 and its complex with morphine
  publication-title: J. Mol. Biol.
  contributor:
    fullname: Ringe
– volume: 71
  start-page: 2925
  year: 1974
  end-page: 2927
  ident: bib22
  article-title: Empirical correlation between hydrophobic free-energy and aqueous cavity surface-area
  publication-title: Proc. Natl Acad. Sci. USA
  contributor:
    fullname: Tanford
– volume: 196
  start-page: 901
  year: 1987
  end-page: 917
  ident: bib17
  article-title: Canonical structures for the hypervariable regions of immunoglobulins
  publication-title: J. Mol. Biol.
  contributor:
    fullname: Lesk
– volume: 31
  start-page: 45
  year: 1995
  end-page: 50
  ident: bib36
  article-title: Dictionaries for Heteros
  publication-title: CCP4/ESF-EACBM Newsletter on Protein Crystallography
  contributor:
    fullname: Kleywegt
– volume: 259
  start-page: 1899
  year: 1993
  end-page: 1901
  ident: bib4
  article-title: Antibody-catalyzed degradation of cocaine
  publication-title: Science
  contributor:
    fullname: Georgiadis
– volume: 311
  start-page: 9
  year: 2001
  end-page: 15
  ident: bib13
  article-title: Crystal structure of a cocaine-binding antibody
  publication-title: J. Mol. Biol.
  contributor:
    fullname: Wilson
– volume: 35
  start-page: 63
  year: 2001
  end-page: 87
  ident: bib1
  article-title: Catalytic antibodies - structure and function
  publication-title: Cell Biochem. Biophys.
  contributor:
    fullname: Janda
– volume: 7
  start-page: 306
  year: 2001
  end-page: 317
  ident: bib39
  article-title: GROMACS 3.0: a package for molecular simulation and trajectory analysis
  publication-title: J. Mol. Mod.
  contributor:
    fullname: van der Spoel
– volume: 91
  start-page: 43
  year: 1995
  end-page: 56
  ident: bib38
  article-title: GROMACS: a message-passing parallel molecular dynamics implementation
  publication-title: Comp. Phys. Commun.
  contributor:
    fullname: van Drunen
– volume: 29
  start-page: 205
  year: 2001
  end-page: 206
  ident: bib37
  article-title: Kabat database and its applications: future directions
  publication-title: Nucl. Acids Res.
  contributor:
    fullname: Wu
– volume: 97
  start-page: 6202
  year: 2000
  end-page: 6206
  ident: bib3
  article-title: Cocaine vaccines: antibody protection against relapse in a rat model
  publication-title: Proc. Natl Acad. Sci. USA
  contributor:
    fullname: Janda
– volume: 116
  start-page: 8722
  year: 1994
  end-page: 8732
  ident: bib35
  article-title: Conformational, aqueous solvation and p
  publication-title: J. Am. Chem. Soc.
  contributor:
    fullname: MacKerell
– volume: 84
  start-page: 8075
  year: 1987
  end-page: 8079
  ident: bib8
  article-title: 3-Dimensional structure of an antibody–antigen complex
  publication-title: Proc. Natl Acad. Sci. USA
  contributor:
    fullname: Davies
– volume: 11
  start-page: 2308
  year: 2002
  end-page: 2315
  ident: bib12
  article-title: How do two unrelated antibodies, HyHEL-10 and F9.13.7, recognize the same epitope of hen egg-white lysozyme?
  publication-title: Protein Sci.
  contributor:
    fullname: Kirsch
– volume: 273
  start-page: 927
  year: 1997
  end-page: 948
  ident: bib18
  article-title: Standard conformations for the canonical structures of immunoglobulins
  publication-title: J. Mol. Biol.
  contributor:
    fullname: Chothia
– volume: 86
  start-page: 5938
  year: 1989
  end-page: 5942
  ident: bib9
  article-title: Structure of an antibody antigen complex - crystal-structure of the HyHEL-10 Fab-lysozyme complex
  publication-title: Proc. Natl Acad. Sci. USA
  contributor:
    fullname: Davies
– volume: 91
  start-page: 6423
  year: 1994
  end-page: 6427
  ident: bib19
  article-title: Structure of a single-chain antibody variable domain (Fv) fragment complexed with a carbohydrate antigen at 1.7-Å resolution
  publication-title: Proc. Natl Acad. Sci. USA
  contributor:
    fullname: Narang
– volume: 96
  start-page: 9459
  year: 1999
  end-page: 9464
  ident: bib29
  article-title: Cation–pi interactions in structural biology
  publication-title: Proc. Natl Acad. Sci. USA
  contributor:
    fullname: Dougherty
– volume: 90
  start-page: 7711
  year: 1993
  end-page: 7715
  ident: bib10
  article-title: 3-Dimensional structure of a heteroclitic antigen–antibody cross-reaction complex
  publication-title: Proc. Natl Acad. Sci. USA
  contributor:
    fullname: Houdusse
– volume: 236
  start-page: 247
  year: 1994
  end-page: 274
  ident: bib14
  article-title: Local and transmitted conformational-changes on complexation of an anti-sweetener Fab
  publication-title: J. Mol. Biol.
  contributor:
    fullname: Edmundson
– volume: 378
  start-page: 727
  year: 1995
  end-page: 730
  ident: bib5
  article-title: Suppression of psychoactive effects of cocaine by active immunization
  publication-title: Nature
  contributor:
    fullname: Janda
– volume: 16
  start-page: 796
  year: 1963
  end-page: 801
  ident: bib43
  article-title: The crystal and molecular structure of
  publication-title: Acta Crystallog.
  contributor:
    fullname: Barnes
– volume: 48
  start-page: 117
  year: 2002
  end-page: 125
  ident: bib30
  article-title: The nature of intermolecular interactions between aromatic amino acid residues
  publication-title: Proteins: Struct. Funct. Genet.
  contributor:
    fullname: Schettino
– volume: 275
  start-page: 269
  year: 1998
  end-page: 294
  ident: bib20
  article-title: Conformation of the third hypervariable region in the VH domain of immunoglobulins
  publication-title: J. Mol. Biol.
  contributor:
    fullname: Lesk
– volume: 248
  start-page: 712
  year: 1990
  end-page: 719
  ident: bib21
  article-title: Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8
  publication-title: Science
  contributor:
    fullname: Wilson
– volume: 302
  start-page: 853
  year: 2000
  ident: 10.1016/j.jmb.2005.03.080_bib15
  article-title: The three-dimensional structure of a complex of a murine Fab (NC10.14) with a potent sweetener (NC174): an illustration of structural diversity in antigen recognition by immunoglobulins
  publication-title: J. Mol. Biol.
  doi: 10.1006/jmbi.2000.4083
  contributor:
    fullname: Guddat
– volume: 389
  start-page: 271
  year: 1997
  ident: 10.1016/j.jmb.2005.03.080_bib25
  article-title: The interplay between binding energy and catalysis in the evolution of a catalytic antibody
  publication-title: Nature
  doi: 10.1038/38470
  contributor:
    fullname: Ulrich
– volume: 236
  start-page: 247
  year: 1994
  ident: 10.1016/j.jmb.2005.03.080_bib14
  article-title: Local and transmitted conformational-changes on complexation of an anti-sweetener Fab
  publication-title: J. Mol. Biol.
  doi: 10.1006/jmbi.1994.1133
  contributor:
    fullname: Guddat
– volume: 90
  start-page: 7711
  year: 1993
  ident: 10.1016/j.jmb.2005.03.080_bib10
  article-title: 3-Dimensional structure of a heteroclitic antigen–antibody cross-reaction complex
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.90.16.7711
  contributor:
    fullname: Chitarra
– volume: 116
  start-page: 8722
  year: 1994
  ident: 10.1016/j.jmb.2005.03.080_bib35
  article-title: Conformational, aqueous solvation and pKa contributions to the binding and activity of cocaine, WIN 32 065-2, and the WIN vinyl analog
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja00098a035
  contributor:
    fullname: Yang
– volume: 23
  start-page: 600
  year: 2002
  ident: 10.1016/j.jmb.2005.03.080_bib40
  article-title: A novel computer program for fast and exact calculation of accessible and molecular surface areas and average surface curvature
  publication-title: J. Comp. Chem.
  doi: 10.1002/jcc.10061
  contributor:
    fullname: Tsodikov
– volume: 35
  start-page: 63
  year: 2001
  ident: 10.1016/j.jmb.2005.03.080_bib1
  article-title: Catalytic antibodies - structure and function
  publication-title: Cell Biochem. Biophys.
  doi: 10.1385/CBB:35:1:63
  contributor:
    fullname: Wentworth
– volume: 273
  start-page: 927
  year: 1997
  ident: 10.1016/j.jmb.2005.03.080_bib18
  article-title: Standard conformations for the canonical structures of immunoglobulins
  publication-title: J. Mol. Biol.
  doi: 10.1006/jmbi.1997.1354
  contributor:
    fullname: Al-Lazikani
– volume: 96
  start-page: 9459
  year: 1999
  ident: 10.1016/j.jmb.2005.03.080_bib29
  article-title: Cation–pi interactions in structural biology
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.96.17.9459
  contributor:
    fullname: Gallivan
– volume: 91
  start-page: 43
  year: 1995
  ident: 10.1016/j.jmb.2005.03.080_bib38
  article-title: GROMACS: a message-passing parallel molecular dynamics implementation
  publication-title: Comp. Phys. Commun.
  doi: 10.1016/0010-4655(95)00042-E
  contributor:
    fullname: Berendsen
– volume: 7
  start-page: 306
  year: 2001
  ident: 10.1016/j.jmb.2005.03.080_bib39
  article-title: GROMACS 3.0: a package for molecular simulation and trajectory analysis
  publication-title: J. Mol. Mod.
  doi: 10.1007/s008940100045
  contributor:
    fullname: Lindahl
– volume: 71
  start-page: 2925
  year: 1974
  ident: 10.1016/j.jmb.2005.03.080_bib22
  article-title: Empirical correlation between hydrophobic free-energy and aqueous cavity surface-area
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.71.8.2925
  contributor:
    fullname: Reynolds
– volume: 196
  start-page: 901
  year: 1987
  ident: 10.1016/j.jmb.2005.03.080_bib17
  article-title: Canonical structures for the hypervariable regions of immunoglobulins
  publication-title: J. Mol. Biol.
  doi: 10.1016/0022-2836(87)90412-8
  contributor:
    fullname: Chothia
– volume: 28
  start-page: 235
  year: 2000
  ident: 10.1016/j.jmb.2005.03.080_bib23
  article-title: The Protein Data Bank
  publication-title: Nucl. Acids Res.
  doi: 10.1093/nar/28.1.235
  contributor:
    fullname: Berman
– volume: 84
  start-page: 8075
  year: 1987
  ident: 10.1016/j.jmb.2005.03.080_bib8
  article-title: 3-Dimensional structure of an antibody–antigen complex
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.84.22.8075
  contributor:
    fullname: Sheriff
– volume: 275
  start-page: 269
  year: 1998
  ident: 10.1016/j.jmb.2005.03.080_bib20
  article-title: Conformation of the third hypervariable region in the VH domain of immunoglobulins
  publication-title: J. Mol. Biol.
  doi: 10.1006/jmbi.1997.1442
  contributor:
    fullname: Morea
– volume: 248
  start-page: 712
  year: 1990
  ident: 10.1016/j.jmb.2005.03.080_bib21
  article-title: Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8Å
  publication-title: Science
  doi: 10.1126/science.2333521
  contributor:
    fullname: Stanfield
– volume: 276
  start-page: 307
  year: 1997
  ident: 10.1016/j.jmb.2005.03.080_bib32
  article-title: Processing of X-ray diffraction data collected in oscillation mode
  publication-title: Methods Enzymol.
  doi: 10.1016/S0076-6879(97)76066-X
  contributor:
    fullname: Otwinowski
– volume: 250
  start-page: 81
  year: 2001
  ident: 10.1016/j.jmb.2005.03.080_bib2
  article-title: Protein and antibody arrays and their medical applications
  publication-title: J. Immunol. Methods
  doi: 10.1016/S0022-1759(01)00325-8
  contributor:
    fullname: Cahill
– volume: 259
  start-page: 1899
  year: 1993
  ident: 10.1016/j.jmb.2005.03.080_bib4
  article-title: Antibody-catalyzed degradation of cocaine
  publication-title: Science
  doi: 10.1126/science.8456315
  contributor:
    fullname: Landry
– volume: 29
  start-page: 205
  year: 2001
  ident: 10.1016/j.jmb.2005.03.080_bib37
  article-title: Kabat database and its applications: future directions
  publication-title: Nucl. Acids Res.
  doi: 10.1093/nar/29.1.205
  contributor:
    fullname: Johnson
– volume: 16
  start-page: 796
  year: 1963
  ident: 10.1016/j.jmb.2005.03.080_bib43
  article-title: The crystal and molecular structure of l-cocaine hydrochloride
  publication-title: Acta Crystallog.
  doi: 10.1107/S0365110X6300205X
  contributor:
    fullname: Gabe
– volume: 31
  start-page: 45
  year: 1995
  ident: 10.1016/j.jmb.2005.03.080_bib36
  article-title: Dictionaries for Heteros
  publication-title: CCP4/ESF-EACBM Newsletter on Protein Crystallography
  contributor:
    fullname: Kleywegt
– volume: 48
  start-page: 117
  year: 2002
  ident: 10.1016/j.jmb.2005.03.080_bib30
  article-title: The nature of intermolecular interactions between aromatic amino acid residues
  publication-title: Proteins: Struct. Funct. Genet.
  doi: 10.1002/prot.10116
  contributor:
    fullname: Gervasio
– volume: D54
  start-page: 905
  year: 1998
  ident: 10.1016/j.jmb.2005.03.080_bib34
  article-title: Crystallography and NMR system (CNS): a new software system for macromolecular structure determination
  publication-title: Acta Crystallog.
  contributor:
    fullname: Brunger
– volume: 233
  start-page: 747
  year: 1986
  ident: 10.1016/j.jmb.2005.03.080_bib7
  article-title: 3-Dimensional structure of an antigen-antibody complex at 2.8-Å resolution
  publication-title: Science
  doi: 10.1126/science.2426778
  contributor:
    fullname: Amit
– volume: 337
  start-page: 691
  year: 2004
  ident: 10.1016/j.jmb.2005.03.080_bib28
  article-title: Anchoring a cationic ligand: the structure of the Fab fragment of the anti-morphine antibody 9B1 and its complex with morphine
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2003.12.084
  contributor:
    fullname: Pozharski
– volume: 36
  start-page: 944
  year: 2003
  ident: 10.1016/j.jmb.2005.03.080_bib42
  article-title: POVScript+: a program for model and data visualization using persistence of vision ray-tracing
  publication-title: J. Appl. Crystallog.
  doi: 10.1107/S0021889803006721
  contributor:
    fullname: Fenn
– volume: 86
  start-page: 5938
  year: 1989
  ident: 10.1016/j.jmb.2005.03.080_bib9
  article-title: Structure of an antibody antigen complex - crystal-structure of the HyHEL-10 Fab-lysozyme complex
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.86.15.5938
  contributor:
    fullname: Padlan
– volume: 243
  start-page: 767
  year: 1994
  ident: 10.1016/j.jmb.2005.03.080_bib11
  article-title: 3-Dimensional structures of the free and the antigen-complexed Fab from monoclonal antilysozyme antibody-D44.1
  publication-title: J. Mol. Biol.
  doi: 10.1016/0022-2836(94)90046-9
  contributor:
    fullname: Braden
– volume: 91
  start-page: 6423
  year: 1994
  ident: 10.1016/j.jmb.2005.03.080_bib19
  article-title: Structure of a single-chain antibody variable domain (Fv) fragment complexed with a carbohydrate antigen at 1.7-Å resolution
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.91.14.6423
  contributor:
    fullname: Zdanov
– volume: 11
  start-page: 2308
  year: 2002
  ident: 10.1016/j.jmb.2005.03.080_bib12
  article-title: How do two unrelated antibodies, HyHEL-10 and F9.13.7, recognize the same epitope of hen egg-white lysozyme?
  publication-title: Protein Sci.
  doi: 10.1110/ps.0209102
  contributor:
    fullname: Pons
– volume: 378
  start-page: 727
  year: 1995
  ident: 10.1016/j.jmb.2005.03.080_bib5
  article-title: Suppression of psychoactive effects of cocaine by active immunization
  publication-title: Nature
  doi: 10.1038/378727a0
  contributor:
    fullname: Carrera
– volume: 36
  start-page: 164
  year: 1997
  ident: 10.1016/j.jmb.2005.03.080_bib24
  article-title: Energetic and kinetic contributions of contact residues of antibody D1.3 in the interaction with lysozyme
  publication-title: Biochemistry
  doi: 10.1021/bi961419y
  contributor:
    fullname: England
– volume: 311
  start-page: 9
  year: 2001
  ident: 10.1016/j.jmb.2005.03.080_bib13
  article-title: Crystal structure of a cocaine-binding antibody
  publication-title: J. Mol. Biol.
  doi: 10.1006/jmbi.2001.4839
  contributor:
    fullname: Larsen
– volume: 132
  start-page: 211
  year: 1970
  ident: 10.1016/j.jmb.2005.03.080_bib16
  article-title: An analysis of sequences of variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.132.2.211
  contributor:
    fullname: Wu
– volume: 39
  start-page: 627
  year: 2000
  ident: 10.1016/j.jmb.2005.03.080_bib26
  article-title: Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement
  publication-title: Biochemistry
  doi: 10.1021/bi9924314
  contributor:
    fullname: Mundorff
– volume: 273
  start-page: 28576
  year: 1998
  ident: 10.1016/j.jmb.2005.03.080_bib27
  article-title: Crystal structure of monoclonal 6B5 fab complexed with phencyclidine
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.273.44.28576
  contributor:
    fullname: Lim
– volume: 44
  start-page: 400
  year: 2001
  ident: 10.1016/j.jmb.2005.03.080_bib31
  article-title: What axe the dielectric “constants” of proteins and how to validate electrostatic models?
  publication-title: Proteins: Struct. Funct. Genet.
  doi: 10.1002/prot.1106
  contributor:
    fullname: Schutz
– volume: 50
  start-page: 157
  year: 1994
  ident: 10.1016/j.jmb.2005.03.080_bib33
  article-title: AMoRe: an automated package for molecular replacement
  publication-title: Acta Crystallog. sect. A
  doi: 10.1107/S0108767393007597
  contributor:
    fullname: Navaza
– volume: 93
  start-page: 7
  year: 1996
  ident: 10.1016/j.jmb.2005.03.080_bib6
  article-title: Interactions of protein antigens with antibodies
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.93.1.7
  contributor:
    fullname: Davies
– volume: 11
  start-page: 281
  year: 1991
  ident: 10.1016/j.jmb.2005.03.080_bib41
  article-title: Protein folding and association - insights from the interfacial and thermodynamic properties of hydrocarbons
  publication-title: Proteins: Struct. Funct. Genet.
  doi: 10.1002/prot.340110407
  contributor:
    fullname: Nicholls
– volume: 97
  start-page: 6202
  year: 2000
  ident: 10.1016/j.jmb.2005.03.080_bib3
  article-title: Cocaine vaccines: antibody protection against relapse in a rat model
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.97.11.6202
  contributor:
    fullname: Carrera
SSID ssj0005348
ssj0001610
Score 2.0021653
Snippet Antibodies against cocaine and other drugs of abuse are the basis for diagnostic tests for the presence of those drugs in human serum. The 1.7 Å resolution...
Antibodies against cocaine and other drugs of abuse are the basis for diagnostic tests for the presence of those drugs in human serum. The 1.7A resolution...
SourceID osti
proquest
crossref
pubmed
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 570
SubjectTerms 60 APPLIED LIFE SCIENCES
Amino Acid Sequence
Animals
ANTIBODIES
antibody engineering
antibody structure
COCAINE
Cocaine - analysis
Cocaine - blood
Cocaine - immunology
CRYSTAL GROWTH
Hydrogen Bonding
Immunoglobulin Fab Fragments - chemistry
Immunoglobulin Fab Fragments - genetics
Immunoglobulin Fab Fragments - immunology
immunotherapy
Ligands
Mice
Molecular Sequence Data
national synchrotron light source
Protein Binding - immunology
Protein Structure, Tertiary
protein–ligand interaction
Static Electricity
Structural Homology, Protein
Title Diversity in Hapten Recognition: Structural Study of an Anti-cocaine Antibody M82G2
URI https://dx.doi.org/10.1016/j.jmb.2005.03.080
https://www.ncbi.nlm.nih.gov/pubmed/15885702
https://search.proquest.com/docview/17503688
https://search.proquest.com/docview/67832111
https://www.osti.gov/biblio/884093
Volume 349
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB7Boqq9VIW2sLSlPvRUKZD4kTi9rRbo0goOpUjcLNuxpUUiWanbA5f-9s4ksRAS9NBbHh7Jnknm4fk8A_Cp4pFzz22G5iFm0jVlphtdZkXlnKy0L7ymA87nF-XiSn67VtcbME9nYQhWOer-Qaf32np8cjRy82i1XNIZX9q9EOiP9-kutQlbaI6knMDW7Oz74uIe6SGkTkXDiSAlN3uY182tG3dWxGFfHPJx8zTp8I972gvtrdHpK3g5upFsNsx0GzZCuwPPhsaSdzvwfJ76uL2Gy-MEvWDLli3sCr1k9iPhhrr2C7vsa8hS_Q1GsMI71kVmWzZr18sM9aVFR7S_cR2-O9f8K38DV6cnP-eLbGylkHlZyXWmQqw5GiNhS6-s9zVecR59lVtRRCdtkFr4KojGS1_jAFc3ynkVuM9DEYV4C5O2a8MesCY2eYVDcu0wdlG-DrlwsazrylFWsJjC58RBsxoqZpgEJbsxyG7qfKlMLgyyewoy8dg8ELtBjf4vsn2SB5FQqVtPmCCk0RStiil8TFIyyGpKgNg2dL9_mYKStqXWT49A0y0wJMZF7A7ivV-C0tQLgO__34zfwYu-6Ct1PcrfwwQFGz6gO7N2B7B5-Kc4GD_av_I88g0
link.rule.ids 230,315,786,790,891,4521,24144,27957,27958,45620,45714
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB7RRRVcKkofLKXFh54qpSR-xE5vq21pKOweCkjcLNuxpUVqshLLgX_fcRILVSo99JaHR7Jnknl4Ps8AfJQ0UOqoydA8hIzbpsxUo8qskNZyqVzhVDzgvFiW9TX_cSNutmCezsJEWOWo-wed3mvr8cnJyM2T9WoVz_jG3QuG_nif7hLPYJsLWfAJbM_OzuvlI9KDcZWKhkeClNzsYV63v-y4s8I-98Uh_26eJh3-cU97ob01Ot2DF6MbSWbDTF_Clm_34fnQWPJhH3bmqY_bK7j8mqAXZNWS2qzRSyY_E26oa7-Qy76GbKy_QSKs8IF0gZiWzNrNKkN9adAR7W9sh-8Win6nr-H69NvVvM7GVgqZ45JvMuFDRdEYMVM6YZyr8IrS4GRuWBEsN54r5qRnjeOuwgG2aoR1wlOX-yIw9gYmbdf6AyBNaHKJQ3JlMXYRrvI5s6GsKmljVrCYwqfEQb0eKmboBCW71cju2PlS6JxpZPcUeOKx_kPsGjX6v8gOozwiSSx16yImCGlUjFbZFI6TlDSyOiZATOu7-ztdxKRtqdTTI9B0MwyJcRFvB_E-LkGo2AuAHv7fjI9hp75aXOiLs-X5O9jtC8DGDkj5EUxQyP49ujYb-2H8dH8DyHvz_w
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Diversity+in+hapten+recognition%3A+structural+study+of+an+anti-cocaine+antibody+M82G2&rft.jtitle=Journal+of+molecular+biology&rft.au=Pozharski%2C+Edwin&rft.au=Moulin%2C+Aaron&rft.au=Hewagama%2C+Anura&rft.au=Shanafelt%2C+Armen+B&rft.date=2005-06-10&rft.issn=0022-2836&rft.volume=349&rft.issue=3&rft.spage=570&rft_id=info:doi/10.1016%2Fj.jmb.2005.03.080&rft_id=info%3Apmid%2F15885702&rft.externalDocID=15885702
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-2836&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-2836&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-2836&client=summon