Causal effects of blood lipids on amyotrophic lateral sclerosis: a Mendelian randomization study

• Published in: Human molecular genetics Vol. 28; no. 4; pp. 688 - 697
• Main Authors: Zeng, Ping, Zhou, Xiang
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 15.02.2019
• Subjects: Amyotrophic Lateral Sclerosis - blood; Amyotrophic Lateral Sclerosis - genetics; Amyotrophic Lateral Sclerosis - physiopathology; Association Studies; Cholesterol - blood; Cholesterol - genetics; Female; Humans; Lipids - blood; Lipids - genetics; Lipoproteins, HDL - blood; Lipoproteins, HDL - genetics; Lipoproteins, LDL - blood; Lipoproteins, LDL - genetics; Male; Mendelian Randomization Analysis; Polymorphism, Single Nucleotide - genetics; Triglycerides - blood; Triglycerides - genetics

Abstract Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disorder that is predicted to increase across the globe by ~70% in the following decades. Understanding the disease causal mechanism underlying ALS and identifying modifiable risks factors for ALS hold the key for t...