Single-cell transcriptomic analysis defines the interplay between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma

• Published in: Cell research Vol. 30; no. 11; pp. 950 - 965
• Main Authors: Jin, Shanzhao, Li, Ruoyan, Chen, Ming-Yuan, Yu, Chao, Tang, Lin-Quan, Liu, Yan-Min, Li, Jiang-Ping, Liu, Yi-Na, Luo, Yi-Ling, Zhao, Yifan, Zhang, Yu, Xia, Tian-Liang, Liu, Shang-Xin, Liu, Qi, Wang, Guan-Nan, You, Rui, Peng, Jing-Yun, Li, Jiang, Han, Feng, Wang, Jianwei, Chen, Qiu-Yan, Zhang, Li, Mai, Hai-Qiang, Gewurz, Benjamin E., Zhao, Bo, Young, Lawrence S., Zhong, Qian, Bai, Fan, Zeng, Mu-Sheng
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.11.2020; Nature Publishing Group
• Subjects: 13/31; 13/51; 38/32; 38/39; 631/67/327; 631/67/69; 64/60; 82/1; Biomedical and Life Sciences; CD8 antigen; Cell Biology; Ecosystems; Epstein-Barr virus; Gene sequencing; Immune system; Interferon; Life Sciences; Lymphocytes; Lymphocytes T; Malignancy; Nasopharyngeal carcinoma; Ribonucleic acid; RNA; Throat cancer; Tumor cells; Tumorigenesis; Tumors; γ-Interferon

Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignancy with a complex tumor ecosystem. How the interplay between tumor cells, EBV, and the microenvironment contributes to NPC progression and immune evasion remains unclear. Here we performed single-cell RNA sequencing on...