Ectopic calcification and formation of mineralo-organic particles in arteries of diabetic subjects
Vascular calcification occurs in various diseases including atherosclerosis, chronic kidney disease and type 2 diabetes but the mechanism underlying mineral deposition remains incompletely understood. Here we examined lower limb arteries of type 2 diabetes subjects for the presence of ectopic calcif...
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| Published in | Scientific reports Vol. 10; no. 1; p. 8545 |
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| Format | Journal Article |
| Language | English |
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22.05.2020
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| Abstract | Vascular calcification occurs in various diseases including atherosclerosis, chronic kidney disease and type 2 diabetes but the mechanism underlying mineral deposition remains incompletely understood. Here we examined lower limb arteries of type 2 diabetes subjects for the presence of ectopic calcification and mineral particles using histology, electron microscopy and spectroscopy analyses. While arteries of healthy controls showed no calcification following von Kossa staining, arteries from 83% of diabetic individuals examined (19/23) revealed microscopic mineral deposits, mainly within the tunica media. Mineralo-organic particles containing calcium phosphate and proteins such as albumin, fetuin-A and apolipoprotein-A1 were detected in calcified arteries. Ectopic calcification and mineralo-organic particles were observed in a majority of diabetic patients and predominantly in arteries showing hyperplasia. While a low number of subjects was examined and information about disease severity and patient characteristics is lacking, these calcifications and mineralo-organic particles may represent signs of tissue dysfunction. |
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| AbstractList | Vascular calcification occurs in various diseases including atherosclerosis, chronic kidney disease and type 2 diabetes but the mechanism underlying mineral deposition remains incompletely understood. Here we examined lower limb arteries of type 2 diabetes subjects for the presence of ectopic calcification and mineral particles using histology, electron microscopy and spectroscopy analyses. While arteries of healthy controls showed no calcification following von Kossa staining, arteries from 83% of diabetic individuals examined (19/23) revealed microscopic mineral deposits, mainly within the tunica media. Mineralo-organic particles containing calcium phosphate and proteins such as albumin, fetuin-A and apolipoprotein-A1 were detected in calcified arteries. Ectopic calcification and mineralo-organic particles were observed in a majority of diabetic patients and predominantly in arteries showing hyperplasia. While a low number of subjects was examined and information about disease severity and patient characteristics is lacking, these calcifications and mineralo-organic particles may represent signs of tissue dysfunction.Vascular calcification occurs in various diseases including atherosclerosis, chronic kidney disease and type 2 diabetes but the mechanism underlying mineral deposition remains incompletely understood. Here we examined lower limb arteries of type 2 diabetes subjects for the presence of ectopic calcification and mineral particles using histology, electron microscopy and spectroscopy analyses. While arteries of healthy controls showed no calcification following von Kossa staining, arteries from 83% of diabetic individuals examined (19/23) revealed microscopic mineral deposits, mainly within the tunica media. Mineralo-organic particles containing calcium phosphate and proteins such as albumin, fetuin-A and apolipoprotein-A1 were detected in calcified arteries. Ectopic calcification and mineralo-organic particles were observed in a majority of diabetic patients and predominantly in arteries showing hyperplasia. While a low number of subjects was examined and information about disease severity and patient characteristics is lacking, these calcifications and mineralo-organic particles may represent signs of tissue dysfunction. Vascular calcification occurs in various diseases including atherosclerosis, chronic kidney disease and type 2 diabetes but the mechanism underlying mineral deposition remains incompletely understood. Here we examined lower limb arteries of type 2 diabetes subjects for the presence of ectopic calcification and mineral particles using histology, electron microscopy and spectroscopy analyses. While arteries of healthy controls showed no calcification following von Kossa staining, arteries from 83% of diabetic individuals examined (19/23) revealed microscopic mineral deposits, mainly within the tunica media. Mineralo-organic particles containing calcium phosphate and proteins such as albumin, fetuin-A and apolipoprotein-A1 were detected in calcified arteries. Ectopic calcification and mineralo-organic particles were observed in a majority of diabetic patients and predominantly in arteries showing hyperplasia. While a low number of subjects was examined and information about disease severity and patient characteristics is lacking, these calcifications and mineralo-organic particles may represent signs of tissue dysfunction. |
| ArticleNumber | 8545 |
| Author | Wu, Cheng-Yeu Martel, Jan Young, John D. |
| Author_xml | – sequence: 1 givenname: Cheng-Yeu surname: Wu fullname: Wu, Cheng-Yeu organization: Laboratory of Nanomaterials, Chang Gung University, Center for Molecular and Clinical Immunology, Chang Gung University, Research Center of Bacterial Pathogenesis, Chang Gung University – sequence: 2 givenname: Jan surname: Martel fullname: Martel, Jan organization: Laboratory of Nanomaterials, Chang Gung University, Center for Molecular and Clinical Immunology, Chang Gung University, Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital – sequence: 3 givenname: John D. surname: Young fullname: Young, John D. email: jdyoung@mail.cgu.edu.tw organization: Laboratory of Nanomaterials, Chang Gung University, Center for Molecular and Clinical Immunology, Chang Gung University, Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Biochemical Engineering Research Center, Ming Chi University of Technology |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32444654$$D View this record in MEDLINE/PubMed |
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Surg.20102440841410.1016/j.avsg.2009.11.006 PengHHPhysicochemical and biological properties of biomimetic mineralo-protein nanoparticles formed spontaneously in biological fluidsSmall20139229723071:CAS:528:DC%2BC38XhvVKns7vP10.1002/smll.201202270 LeonBMMaddoxTMDiabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future researchWorld J. Diabetes201561246125810.4239/wjd.v6.i13.1246 WuCYNonribosomal synthesis of fengycin on an enzyme complex formed by fengycin synthetasesJ. Biol. Chem.2007282560856161:CAS:528:DC%2BD2sXhvVaitrg%3D10.1074/jbc.M609726200 PricePAWilliamsonMKNguyenTMThanTNSerum levels of the fetuin-mineral complex correlate with artery calcification in the ratJ. Biol. Chem.2004279159416001:CAS:528:DC%2BD2cXisF2htQ%3D%3D10.1074/jbc.M305199200 CY Wu (65276_CR9) 2009; 4 DO Dahle (65276_CR29) 2016; 16 TY Wong (65276_CR6) 2015; 5 H Yamada (65276_CR27) 2018; 23 A Pasch (65276_CR32) 2012; 23 JD Young (65276_CR7) 2009; 4 RJ Rennenberg (65276_CR17) 2010; 14 PA Price (65276_CR24) 2004; 279 JD Young (65276_CR8) 2009; 4 G Schlieper (65276_CR15) 2010; 21 65276_CR1 65276_CR2 RC Shroff (65276_CR5) 2007; 20 Y Miura (65276_CR33) 2018; 8 NX Chen (65276_CR4) 2003; 3 J Martel (65276_CR11) 2016; 8 V Cardenas (65276_CR18) 2018; 108 CY Wu (65276_CR12) 2018; 8 HH Peng (65276_CR22) 2013; 9 MA Allison (65276_CR31) 2012; 32 CY Wu (65276_CR34) 2013; 8 TY Wong (65276_CR19) 2015; 10 G Schlieper (65276_CR16) 2010; 24 CY Wu (65276_CR20) 2013; 288 ER Smith (65276_CR28) 2014; 25 CY Wu (65276_CR21) 2007; 282 A Heiss (65276_CR25) 2008; 283 BM Leon (65276_CR3) 2015; 6 PA Price (65276_CR23) 2002; 277 I Matsui (65276_CR26) 2009; 75 J Martel (65276_CR13) 2016; 11 HH Peng (65276_CR35) 2017; 7 M Pruijm (65276_CR30) 2017; 35 J Martel (65276_CR14) 2018; 13 J Martel (65276_CR10) 2011; 418 |
| References_xml | – reference: MartelJWuCYPengHHYoungJDMineralo-organic nanoparticles in health and disease: an overview of recent findingsNanomedicine2018131787179310.2217/nnm-2018-0108 – reference: WuCYMartelJYoungDYoungJDFetuin-A/albumin-mineral complexes resembling serum calcium granules and putative nanobacteria: demonstration of a dual inhibition-seeding conceptPLoS one20094e80582009PLoSO...4.8058W10.1371/journal.pone.0008058 – reference: PricePADiscovery of a high molecular weight complex of calcium, phosphate, fetuin, and matrix gamma-carboxyglutamic acid protein in the serum of etidronate-treated ratsJ. Biol. Chem.2002277392639341:CAS:528:DC%2BD38XhsFSrtbs%3D10.1074/jbc.M106366200 – reference: PruijmMSerum calcification propensity is associated with renal tissue oxygenation and resistive index in patients with arterial hypertension or chronic kidney diseaseJ. Hypertens.201735204420521:CAS:528:DC%2BC2sXhtl2kur7P10.1097/HJH.0000000000001406 – reference: WuCYMartelJYoungJDComprehensive organic profiling of biological particles derived from bloodSci. Rep.201882018NatSR...811310W10.1038/s41598-018-29573-6 – reference: WHO. Obesity and overweight, http://www.who.int/en/news-room/fact-sheets/detail/obesity-and-overweight (2018). – reference: PaschANanoparticle-based test measures overall propensity for calcification in serumJ. Am. Soc. Nephrol.201223174417521:CAS:528:DC%2BC38Xhs1Sqt77L10.1681/ASN.2012030240 – reference: WuCYYoungLYoungDMartelJYoungJDBions: a family of biomimetic mineralo-organic complexes derived from biological fluidsPLoS one20138e755012013PLoSO...875501W1:CAS:528:DC%2BC3sXhsFKitb%2FN10.1371/journal.pone.0075501 – reference: SchlieperGUltrastructural analysis of vascular calcifications in uremiaJ. Am. Soc. 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| Title | Ectopic calcification and formation of mineralo-organic particles in arteries of diabetic subjects |
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