N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance
Enhanced von Willebrand factor (VWF) clearance is important in the etiology of von Willebrand disease. However, the molecular mechanisms underlying VWF clearance remain poorly understood. In this study, we investigated the role of VWF domains and specific glycan moieties in regulating in vivo cleara...
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Published in | Blood Vol. 128; no. 15; pp. 1959 - 1968 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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13.10.2016
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Abstract | Enhanced von Willebrand factor (VWF) clearance is important in the etiology of von Willebrand disease. However, the molecular mechanisms underlying VWF clearance remain poorly understood. In this study, we investigated the role of VWF domains and specific glycan moieties in regulating in vivo clearance. Our findings demonstrate that the A1 domain of VWF contains a receptor-recognition site that plays a key role in regulating the interaction of VWF with macrophages. In A1-A2-A3 and full-length VWF, this macrophage-binding site is cryptic but becomes exposed following exposure to shear or ristocetin. Previous studies have demonstrated that the N-linked glycans within the A2 domain play an important role in modulating susceptibility to ADAMTS13 proteolysis. We further demonstrate that these glycans presented at N1515 and N1574 also play a critical role in protecting VWF against macrophage binding and clearance. Indeed, loss of the N-glycan at N1515 resulted in markedly enhanced VWF clearance that was significantly faster than that observed with any previously described VWF mutations. In addition, A1-A2-A3 fragments containing the N1515Q or N1574Q substitutions also demonstrated significantly enhanced clearance. Importantly, clodronate-induced macrophage depletion significantly attenuated the increased clearance observed with N1515Q and N1574Q in both full-length VWF and A1-A2-A3. Finally, we further demonstrate that loss of these N-linked glycans does not enhance clearance in VWF in the presence of a structurally constrained A2 domain. Collectively, these novel findings support the hypothesis that conformation of the VWF A domains plays a critical role in modulating macrophage-mediated clearance of VWF in vivo.
•The A1 domain of VWF contains a cryptic binding site that plays a key role in regulating macrophage binding and clearance.•The N-linked glycans presented at N1515 and N1574 within the A2 domain of VWF modulate macrophage-mediated clearance. |
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AbstractList | Key Points
The A1 domain of VWF contains a cryptic binding site that plays a key role in regulating macrophage binding and clearance. The N-linked glycans presented at N1515 and N1574 within the A2 domain of VWF modulate macrophage-mediated clearance. Enhanced von Willebrand factor (VWF) clearance is important in the etiology of von Willebrand disease. However, the molecular mechanisms underlying VWF clearance remain poorly understood. In this study, we investigated the role of VWF domains and specific glycan moieties in regulating in vivo clearance. Our findings demonstrate that the A1 domain of VWF contains a receptor-recognition site that plays a key role in regulating the interaction of VWF with macrophages. In A1-A2-A3 and full-length VWF, this macrophage-binding site is cryptic but becomes exposed following exposure to shear or ristocetin. Previous studies have demonstrated that the N-linked glycans within the A2 domain play an important role in modulating susceptibility to ADAMTS13 proteolysis. We further demonstrate that these glycans presented at N1515 and N1574 also play a critical role in protecting VWF against macrophage binding and clearance. Indeed, loss of the N-glycan at N1515 resulted in markedly enhanced VWF clearance that was significantly faster than that observed with any previously described VWF mutations. In addition, A1-A2-A3 fragments containing the N1515Q or N1574Q substitutions also demonstrated significantly enhanced clearance. Importantly, clodronate-induced macrophage depletion significantly attenuated the increased clearance observed with N1515Q and N1574Q in both full-length VWF and A1-A2-A3. Finally, we further demonstrate that loss of these N-linked glycans does not enhance clearance in VWF in the presence of a structurally constrained A2 domain. Collectively, these novel findings support the hypothesis that conformation of the VWF A domains plays a critical role in modulating macrophage-mediated clearance of VWF in vivo. •The A1 domain of VWF contains a cryptic binding site that plays a key role in regulating macrophage binding and clearance.•The N-linked glycans presented at N1515 and N1574 within the A2 domain of VWF modulate macrophage-mediated clearance. Enhanced von Willebrand factor (VWF) clearance is important in the etiology of von Willebrand disease. However, the molecular mechanisms underlying VWF clearance remain poorly understood. In this study, we investigated the role of VWF domains and specific glycan moieties in regulating in vivo clearance. Our findings demonstrate that the A1 domain of VWF contains a receptor-recognition site that plays a key role in regulating the interaction of VWF with macrophages. In A1-A2-A3 and full-length VWF, this macrophage-binding site is cryptic but becomes exposed following exposure to shear or ristocetin. Previous studies have demonstrated that the N-linked glycans within the A2 domain play an important role in modulating susceptibility to ADAMTS13 proteolysis. We further demonstrate that these glycans presented at N1515 and N1574 also play a critical role in protecting VWF against macrophage binding and clearance. Indeed, loss of the N-glycan at N1515 resulted in markedly enhanced VWF clearance that was significantly faster than that observed with any previously described VWF mutations. In addition, A1-A2-A3 fragments containing the N1515Q or N1574Q substitutions also demonstrated significantly enhanced clearance. Importantly, clodronate-induced macrophage depletion significantly attenuated the increased clearance observed with N1515Q and N1574Q in both full-length VWF and A1-A2-A3. Finally, we further demonstrate that loss of these N-linked glycans does not enhance clearance in VWF in the presence of a structurally constrained A2 domain. Collectively, these novel findings support the hypothesis that conformation of the VWF A domains plays a critical role in modulating macrophage-mediated clearance of VWF in vivo. |
Author | O'Sullivan, Jamie M. Aguila, Sonia Chion, Alain Laffan, Michael Ward, Soracha Preston, Roger J.S. O'Donnell, James S. Fallon, Padraic G. McKinnon, Thomas A.J. Dalton, Niall Brady, Lauren Sheils, Orla Bergsson, Gudmundur Drakeford, Clive Brophy, Teresa M. |
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Cites_doi | 10.1111/j.1538-7836.2009.03381.x 10.1111/jth.12875 10.1074/jbc.M310436200 10.1111/j.1538-7836.2005.01571.x 10.1182/blood-2008-01-133181 10.1182/blood.V69.6.1691.1691 10.1182/blood-2006-06-032706 10.1182/blood-2009-11-254193 10.1182/blood-2009-09-241547 10.1172/JCI112064 10.1038/nm1760 10.1182/blood.V88.5.1692.1692 10.1182/blood-2011-08-373605 10.1111/jth.12226 10.1182/blood-2014-06-528406 10.1111/j.1432-1033.1986.tb09750.x 10.1073/pnas.142005099 10.1074/jbc.M508316200 10.1182/blood-2006-04-015065 10.1182/blood-2013-04-496851 10.1371/journal.pone.0045111 10.1093/oxfordjournals.jbchem.a022190 10.1182/blood-2009-03-210369 10.1111/jth.12885 10.1172/JCI69458 10.1111/j.1537-2995.2006.00975.x 10.1111/j.1538-7836.2009.03665.x 10.1111/j.1538-7836.2012.04860.x 10.1371/journal.pone.0008668 10.1042/BJ20120810 10.1161/ATVBAHA.111.240309 10.1111/jth.12867 10.1111/j.1365-2141.2009.08052.x 10.1182/blood-2012-10-457507 10.1182/blood-2010-08-303727 10.1182/blood-2002-07-2081 10.1016/0014-5793(83)80334-2 10.1021/bi00359a015 10.1016/S0021-9258(19)50338-6 10.1016/S0092-8674(00)80964-2 10.1371/journal.pone.0037508 10.1002/jlb.45.2.97 10.1126/science.1170905 10.1007/BF01047846 10.1182/blood.V99.1.180 10.3324/haematol.2012.063297 10.1182/blood-2013-06-498303 10.1111/j.1538-7836.2009.03640.x 10.1182/blood-2012-10-415000 10.1182/blood-2007-09-110940 10.1182/blood-2009-12-257949 10.1182/blood-2011-02-306597 10.1083/jcb.99.6.2123 10.1126/science.7544493 10.1016/j.tibs.2006.01.003 10.1016/S0021-9258(19)63384-3 10.1182/blood-2012-09-455089 10.1182/blood-2010-02-267450 10.1038/nature09295 10.1182/blood-2007-06-095042 10.1182/blood-2006-03-010322 10.1111/j.1538-7836.2010.04012.x 10.1182/blood-2007-11-122945 10.1016/S0021-9258(18)54457-4 10.1182/blood-2015-09-672014 10.1161/CIRCULATIONAHA.109.869156 |
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References | van Schooten, Shahbazi, Groot (bib21) 2008; 112 Mohlke, Purkayastha, Westrick (bib31) 1999; 96 Casonato, Pontara, Sartorello (bib15) 2002; 99 Lynch, Lane (bib44) 2016; 127 Preston, Rawley, Gleeson, O'Donnell (bib62) 2013; 121 Baldauf, Schneppenheim, Stacklies (bib45) 2009; 7 Rawley, O'Sullivan, Chion (bib24) 2015; 13 Titani, Kumar, Takio (bib6) 1986; 25 Sodetz, Pizzo, McKee (bib29) 1977; 252 Badirou, Kurdi, Legendre (bib58) 2012; 7 Casari, Lenting, Wohner, Christophe, Denis (bib14) 2013; 11 Pruss, Golder, Bryant (bib19) 2011; 117 Castaman, Tosetto, Rodeghiero (bib16) 2009; 7 Bovenschen, Herz, Grimbergen (bib53) 2003; 101 Stoddart, Andersen, Lynch (bib30) 1996; 88 McGrath, McRae, Smith, O'Donnell (bib47) 2010; 148 Wyss, Choi, Li (bib55) 1995; 269 Kurdi, Cherel, Lenting, Denis, Christophe (bib59) 2012; 7 Kim, Zhang, Zhang, Springer (bib64) 2010; 466 Gill, Endres-Brooks, Bauer, Marks, Montgomery (bib36) 1987; 69 Badirou, Kurdi, Rayes (bib61) 2010; 8 Pegon, Kurdi, Casari (bib39) 2012; 97 Crawley, de Groot, Xiang, Luken, Lane (bib63) 2011; 118 Matsui, Titani, Mizuochi (bib11) 1992; 267 Gallinaro, Cattini, Sztukowska (bib35) 2008; 111 McGrath, McKinnon, Byrne (bib13) 2010; 115 Canis, McKinnon, Nowak (bib7) 2012; 447 Canis, McKinnon, Nowak (bib8) 2010; 8 McKinnon, Chion, Millington, Lane, Laffan (bib42) 2008; 111 Castro-Núñez, Dienava-Verdoold, Herczenik, Mertens, Meijer (bib22) 2012; 10 Zanardelli, Crawley, Chion, Lam, Preston, Lane (bib49) 2006; 281 Mitra, Sinha, Ramya, Surolia (bib57) 2006; 31 Narhi, Arakawa, Aoki (bib54) 1991; 266 Lillicrap (bib1) 2013; 122 Sporn, Chavin, Marder, Wagner (bib4) 1985; 76 Samor, Michalski, Debray (bib10) 1986; 158 Schooten, Tjernberg, Westein (bib17) 2005; 3 Grewal, Uchiyama, Ditto (bib34) 2008; 14 Zhang, Halvorsen, Zhang, Wong, Springer (bib66) 2009; 324 Groeneveld, van Bekkum, Cheung (bib25) 2015; 13 Rayes, Hollestelle, Legendre (bib67) 2010; 115 Rastegarlari, Pegon, Casari (bib23) 2012; 119 Smith, Chen, Dehghan (bib41) 2010; 121 Saint-Lu, Oortwijn, Pegon (bib38) 2012; 32 Wohner, Legendre, Casari, Christophe, Lenting, Denis (bib26) 2015; 13 Wagner, Marder (bib3) 1984; 99 Haberichter, Balistreri, Christopherson (bib28) 2006; 108 Lenting, Westein, Terraube (bib52) 2004; 279 Lenting, Christophe, Denis (bib2) 2015; 125 Casari, Berrou, Lebret (bib27) 2013; 123 van Rooijen, Kors, Kraal (bib51) 1989; 45 Ellies, Ditto, Levy (bib32) 2002; 99 Kimura, Uchida, Nishimura, Yamaguchi (bib56) 1998; 124 Wu, Lin, Cruz, Dong, Zhu (bib65) 2010; 115 McKinnon, Goode, Birdsey (bib43) 2010; 116 Daigneault, Preston, Marriott, Whyte, Dockrell (bib50) 2010; 5 van Schooten, Denis, Lisman (bib33) 2007; 109 Eikenboom, Federici, Dirven (bib20) 2013; 121 Rydz, Swystun, Notley (bib40) 2013; 121 Samor, Michalski, Mazurier (bib12) 1989; 6 Luken, Winn, Emsley, Lane, Crawley (bib46) 2010; 115 Debeire, Montreuil, Samor (bib9) 1983; 151 Jenkins, O'Donnell (bib5) 2006; 46 Harris RL, van den Berg CW, Bowen DJ, ASGR1 and ASGR2, the genes that encode the asialoglycoprotein receptor (Ashwell receptor), are expressed in peripheral blood monocytes and show interindividual differences in transcript profile. Mol Biol Int. 2012;2012:283974. McGrath, van den Biggelaar, Byrne (bib48) 2013; 122 Pendu, Terraube, Christophe (bib60) 2006; 108 Haberichter, Castaman, Budde (bib18) 2008; 111 Grewal (2019111904482047700_B34) 2008; 14 Lenting (2019111904482047700_B52) 2004; 279 Rayes (2019111904482047700_B67) 2010; 115 McKinnon (2019111904482047700_B43) 2010; 116 Rawley (2019111904482047700_B24) 2015; 13 van Schooten (2019111904482047700_B33) 2007; 109 Saint-Lu (2019111904482047700_B38) 2012; 32 Pruss (2019111904482047700_B19) 2011; 117 Crawley (2019111904482047700_B63) 2011; 118 Wagner (2019111904482047700_B3) 1984; 99 van Rooijen (2019111904482047700_B51) 1989; 45 Samor (2019111904482047700_B12) 1989; 6 Harris (2019111904482047700_B37) Kurdi (2019111904482047700_B59) 2012; 7 Mohlke (2019111904482047700_B31) 1999; 96 van Schooten (2019111904482047700_B21) 2008; 112 Smith (2019111904482047700_B41) 2010; 121 Bovenschen (2019111904482047700_B53) 2003; 101 Wohner (2019111904482047700_B26) 2015; 13 McGrath (2019111904482047700_B13) 2010; 115 Luken (2019111904482047700_B46) 2010; 115 Narhi (2019111904482047700_B54) 1991; 266 Pendu (2019111904482047700_B60) 2006; 108 Canis (2019111904482047700_B8) 2010; 8 Mitra (2019111904482047700_B57) 2006; 31 Preston (2019111904482047700_B62) 2013; 121 McGrath (2019111904482047700_B48) 2013; 122 Haberichter (2019111904482047700_B28) 2006; 108 Sporn (2019111904482047700_B4) 1985; 76 Casonato (2019111904482047700_B15) 2002; 99 Groeneveld (2019111904482047700_B25) 2015; 13 Kim (2019111904482047700_B64) 2010; 466 Titani (2019111904482047700_B6) 1986; 25 Gill (2019111904482047700_B36) 1987; 69 Lynch (2019111904482047700_B44) 2016; 127 McKinnon (2019111904482047700_B42) 2008; 111 Wu (2019111904482047700_B65) 2010; 115 Debeire (2019111904482047700_B9) 1983; 151 Canis (2019111904482047700_B7) 2012; 447 Stoddart (2019111904482047700_B30) 1996; 88 Sodetz (2019111904482047700_B29) 1977; 252 Lenting (2019111904482047700_B2) 2015; 125 Lillicrap (2019111904482047700_B1) 2013; 122 Castaman (2019111904482047700_B16) 2009; 7 Daigneault (2019111904482047700_B50) 2010; 5 Matsui (2019111904482047700_B11) 1992; 267 Pegon (2019111904482047700_B39) 2012; 97 Ellies (2019111904482047700_B32) 2002; 99 Zhang (2019111904482047700_B66) 2009; 324 Jenkins (2019111904482047700_B5) 2006; 46 Castro-Núñez (2019111904482047700_B22) 2012; 10 Rastegarlari (2019111904482047700_B23) 2012; 119 Casari (2019111904482047700_B27) 2013; 123 Zanardelli (2019111904482047700_B49) 2006; 281 Kimura (2019111904482047700_B56) 1998; 124 Badirou (2019111904482047700_B61) 2010; 8 Haberichter (2019111904482047700_B18) 2008; 111 Rydz (2019111904482047700_B40) 2013; 121 Schooten (2019111904482047700_B17) 2005; 3 Casari (2019111904482047700_B14) 2013; 11 Badirou (2019111904482047700_B58) 2012; 7 Gallinaro (2019111904482047700_B35) 2008; 111 Eikenboom (2019111904482047700_B20) 2013; 121 Samor (2019111904482047700_B10) 1986; 158 Wyss (2019111904482047700_B55) 1995; 269 Baldauf (2019111904482047700_B45) 2009; 7 McGrath (2019111904482047700_B47) 2010; 148 |
References_xml | – volume: 148 start-page: 834 year: 2010 end-page: 843 ident: bib47 article-title: Platelet von Willebrand factor–structure, function and biological importance. publication-title: Br J Haematol contributor: fullname: O'Donnell – volume: 252 start-page: 5538 year: 1977 end-page: 5546 ident: bib29 article-title: Relationship of sialic acid to function and in vivo survival of human factor VIII/von Willebrand factor protein. publication-title: J Biol Chem contributor: fullname: McKee – volume: 109 start-page: 2430 year: 2007 end-page: 2437 ident: bib33 article-title: Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels. publication-title: Blood contributor: fullname: Lisman – volume: 122 start-page: 4107 year: 2013 end-page: 4110 ident: bib48 article-title: Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis. publication-title: Blood contributor: fullname: Byrne – volume: 99 start-page: 2123 year: 1984 end-page: 2130 ident: bib3 article-title: Biosynthesis of von Willebrand protein by human endothelial cells: processing steps and their intracellular localization. publication-title: J Cell Biol contributor: fullname: Marder – volume: 45 start-page: 97 year: 1989 end-page: 104 ident: bib51 article-title: Macrophage subset repopulation in the spleen: differential kinetics after liposome-mediated elimination. publication-title: J Leukoc Biol contributor: fullname: Kraal – volume: 466 start-page: 992 year: 2010 end-page: 995 ident: bib64 article-title: A mechanically stabilized receptor-ligand flex-bond important in the vasculature. publication-title: Nature contributor: fullname: Springer – volume: 97 start-page: 1855 year: 2012 end-page: 1863 ident: bib39 article-title: Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5. publication-title: Haematologica contributor: fullname: Casari – volume: 121 start-page: 3801 year: 2013 end-page: 3810 ident: bib62 article-title: Elucidating the role of carbohydrate determinants in regulating hemostasis: insights and opportunities. publication-title: Blood contributor: fullname: O'Donnell – volume: 127 start-page: 1711 year: 2016 end-page: 1718 ident: bib44 article-title: N-linked glycan stabilization of the VWF A2 domain. publication-title: Blood contributor: fullname: Lane – volume: 119 start-page: 2126 year: 2012 end-page: 2134 ident: bib23 article-title: Macrophage LRP1 contributes to the clearance of von Willebrand factor. publication-title: Blood contributor: fullname: Casari – volume: 13 start-page: 821 year: 2015 end-page: 826 ident: bib24 article-title: von Willebrand factor arginine 1205 substitution results in accelerated macrophage-dependent clearance in vivo. publication-title: J Thromb Haemost contributor: fullname: Chion – volume: 115 start-page: 370 year: 2010 end-page: 378 ident: bib65 article-title: Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13. publication-title: Blood contributor: fullname: Zhu – volume: 99 start-page: 10042 year: 2002 end-page: 10047 ident: bib32 article-title: Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands. publication-title: Proc Natl Acad Sci USA contributor: fullname: Levy – volume: 447 start-page: 217 year: 2012 end-page: 228 ident: bib7 article-title: Mapping the N-glycome of human von Willebrand factor. publication-title: Biochem J contributor: fullname: Nowak – volume: 123 start-page: 5071 year: 2013 end-page: 5081 ident: bib27 article-title: von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin αIIbβ3. publication-title: J Clin Invest contributor: fullname: Lebret – volume: 14 start-page: 648 year: 2008 end-page: 655 ident: bib34 article-title: The Ashwell receptor mitigates the lethal coagulopathy of sepsis. publication-title: Nat Med contributor: fullname: Ditto – volume: 324 start-page: 1330 year: 2009 end-page: 1334 ident: bib66 article-title: Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor. publication-title: Science contributor: fullname: Springer – volume: 281 start-page: 1555 year: 2006 end-page: 1563 ident: bib49 article-title: ADAMTS13 substrate recognition of von Willebrand factor A2 domain. publication-title: J Biol Chem contributor: fullname: Lane – volume: 25 start-page: 3171 year: 1986 end-page: 3184 ident: bib6 article-title: Amino acid sequence of human von Willebrand factor. publication-title: Biochemistry contributor: fullname: Takio – volume: 158 start-page: 295 year: 1986 end-page: 298 ident: bib10 article-title: Primary structure of a new tetraantennary glycan of the N-acetyllactosaminic type isolated from human factor VIII/von Willebrand factor. publication-title: Eur J Biochem contributor: fullname: Debray – volume: 7 start-page: 2096 year: 2009 end-page: 2105 ident: bib45 article-title: Shear-induced unfolding activates von Willebrand factor A2 domain for proteolysis. publication-title: J Thromb Haemost contributor: fullname: Stacklies – volume: 76 start-page: 1102 year: 1985 end-page: 1106 ident: bib4 article-title: Biosynthesis of von Willebrand protein by human megakaryocytes. publication-title: J Clin Invest contributor: fullname: Wagner – volume: 88 start-page: 1692 year: 1996 end-page: 1699 ident: bib30 article-title: Clearance of normal and type 2A von Willebrand factor in the rat. publication-title: Blood contributor: fullname: Lynch – volume: 96 start-page: 111 year: 1999 end-page: 120 ident: bib31 article-title: Mvwf, a dominant modifier of murine von Willebrand factor, results from altered lineage-specific expression of a glycosyltransferase. publication-title: Cell contributor: fullname: Westrick – volume: 121 start-page: 2336 year: 2013 end-page: 2339 ident: bib20 article-title: VWF propeptide and ratios between VWF, VWF propeptide, and FVIII in the characterization of type 1 von Willebrand disease. publication-title: Blood contributor: fullname: Dirven – volume: 111 start-page: 3540 year: 2008 end-page: 3545 ident: bib35 article-title: A shorter von Willebrand factor survival in O blood group subjects explains how ABO determinants influence plasma von Willebrand factor. publication-title: Blood contributor: fullname: Sztukowska – volume: 46 start-page: 1836 year: 2006 end-page: 1844 ident: bib5 article-title: ABO blood group determines plasma von Willebrand factor levels: a biologic function after all? publication-title: Transfusion contributor: fullname: O'Donnell – volume: 117 start-page: 4358 year: 2011 end-page: 4366 ident: bib19 article-title: Pathologic mechanisms of type 1 VWD mutations R1205H and Y1584C through in vitro and in vivo mouse models. publication-title: Blood contributor: fullname: Bryant – volume: 112 start-page: 1704 year: 2008 end-page: 1712 ident: bib21 article-title: Macrophages contribute to the cellular uptake of von Willebrand factor and factor VIII in vivo. publication-title: Blood contributor: fullname: Groot – volume: 7 start-page: 71 year: 2009 end-page: 74 ident: bib16 article-title: Reduced von Willebrand factor survival in von Willebrand disease: pathophysiologic and clinical relevance. publication-title: J Thromb Haemost contributor: fullname: Rodeghiero – volume: 124 start-page: 857 year: 1998 end-page: 862 ident: bib56 article-title: Promotion of polypeptide folding by interactions with Asn-Glycans. publication-title: J Biochem contributor: fullname: Yamaguchi – volume: 116 start-page: 640 year: 2010 end-page: 648 ident: bib43 article-title: Specific N-linked glycosylation sites modulate synthesis and secretion of von Willebrand factor. publication-title: Blood contributor: fullname: Birdsey – volume: 6 start-page: 263 year: 1989 end-page: 270 ident: bib12 article-title: Primary structure of the major O-glycosidically linked carbohydrate unit of human von Willebrand factor. publication-title: Glycoconj J contributor: fullname: Mazurier – volume: 99 start-page: 180 year: 2002 end-page: 184 ident: bib15 article-title: Reduced von Willebrand factor survival in type Vicenza von Willebrand disease. publication-title: Blood contributor: fullname: Sartorello – volume: 269 start-page: 1273 year: 1995 end-page: 1278 ident: bib55 article-title: Conformation and function of the N-linked glycan in the adhesion domain of human CD2. publication-title: Science contributor: fullname: Li – volume: 111 start-page: 3042 year: 2008 end-page: 3049 ident: bib42 article-title: N-linked glycosylation of VWF modulates its interaction with ADAMTS13. publication-title: Blood contributor: fullname: Laffan – volume: 115 start-page: 4910 year: 2010 end-page: 4913 ident: bib46 article-title: The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function. publication-title: Blood contributor: fullname: Crawley – volume: 7 start-page: e45111 year: 2012 ident: bib59 article-title: Coagulation factor X interaction with macrophages through its N-glycans protects it from a rapid clearance. publication-title: PLoS One contributor: fullname: Christophe – volume: 31 start-page: 156 year: 2006 end-page: 163 ident: bib57 article-title: N-linked oligosaccharides as outfitters for glycoprotein folding, form and function. publication-title: Trends Biochem Sci contributor: fullname: Surolia – volume: 13 start-page: 592 year: 2015 end-page: 600 ident: bib25 article-title: No evidence for a direct effect of von Willebrand factor's ABH blood group antigens on von Willebrand factor clearance. publication-title: J Thromb Haemost contributor: fullname: Cheung – volume: 115 start-page: 2666 year: 2010 end-page: 2673 ident: bib13 article-title: Expression of terminal alpha2-6-linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13. publication-title: Blood contributor: fullname: Byrne – volume: 121 start-page: 1382 year: 2010 end-page: 1392 ident: bib41 article-title: Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. publication-title: Circulation contributor: fullname: Dehghan – volume: 5 start-page: e8668 year: 2010 ident: bib50 article-title: The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages. publication-title: PLoS One contributor: fullname: Dockrell – volume: 267 start-page: 8723 year: 1992 end-page: 8731 ident: bib11 article-title: Structures of the asparagine-linked oligosaccharide chains of human von Willebrand factor. Occurrence of blood group A, B, and H(O) structures. publication-title: J Biol Chem contributor: fullname: Mizuochi – volume: 266 start-page: 23022 year: 1991 end-page: 23026 ident: bib54 article-title: The effect of carbohydrate on the structure and stability of erythropoietin. publication-title: J Biol Chem contributor: fullname: Aoki – volume: 7 start-page: e37508 year: 2012 ident: bib58 article-title: In vivo analysis of the role of O-glycosylations of von Willebrand factor. publication-title: PLoS One contributor: fullname: Legendre – volume: 151 start-page: 22 year: 1983 end-page: 26 ident: bib9 article-title: Structure determination of the major asparagine-linked sugar chain of human factor VIII–von Willebrand factor. publication-title: FEBS Lett contributor: fullname: Samor – volume: 108 start-page: 3344 year: 2006 end-page: 3351 ident: bib28 article-title: Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival. publication-title: Blood contributor: fullname: Christopherson – volume: 11 start-page: 202 year: 2013 end-page: 211 ident: bib14 article-title: Clearance of von Willebrand factor. publication-title: J Thromb Haemost contributor: fullname: Denis – volume: 10 start-page: 1929 year: 2012 end-page: 1937 ident: bib22 article-title: Shear stress is required for the endocytic uptake of the factor VIII-von Willebrand factor complex by macrophages. publication-title: J Thromb Haemost contributor: fullname: Meijer – volume: 122 start-page: 3735 year: 2013 end-page: 3740 ident: bib1 article-title: von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy. publication-title: Blood contributor: fullname: Lillicrap – volume: 3 start-page: 2228 year: 2005 end-page: 2237 ident: bib17 article-title: Cysteine-mutations in von Willebrand factor associated with increased clearance. publication-title: J Thromb Haemost contributor: fullname: Westein – volume: 8 start-page: 2338 year: 2010 end-page: 2340 ident: bib61 article-title: von Willebrand factor clearance does not involve proteolysis by ADAMTS-13. publication-title: J Thromb Haemost contributor: fullname: Rayes – volume: 8 start-page: 137 year: 2010 end-page: 145 ident: bib8 article-title: The plasma von Willebrand factor O-glycome comprises a surprising variety of structures including ABH antigens and disialosyl motifs. publication-title: J Thromb Haemost contributor: fullname: Nowak – volume: 108 start-page: 3746 year: 2006 end-page: 3752 ident: bib60 article-title: P-selectin glycoprotein ligand 1 and beta2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor. publication-title: Blood contributor: fullname: Christophe – volume: 69 start-page: 1691 year: 1987 end-page: 1695 ident: bib36 article-title: The effect of ABO blood group on the diagnosis of von Willebrand disease. publication-title: Blood contributor: fullname: Montgomery – volume: 111 start-page: 4979 year: 2008 end-page: 4985 ident: bib18 article-title: Identification of type 1 von Willebrand disease patients with reduced von Willebrand factor survival by assay of the VWF propeptide in the European study: molecular and clinical markers for the diagnosis and management of type 1 VWD (MCMDM-1VWD). publication-title: Blood contributor: fullname: Budde – volume: 32 start-page: 894 year: 2012 end-page: 901 ident: bib38 article-title: Identification of galectin-1 and galectin-3 as novel partners for von Willebrand factor. publication-title: Arterioscler Thromb Vasc Biol contributor: fullname: Pegon – volume: 115 start-page: 4870 year: 2010 end-page: 4877 ident: bib67 article-title: Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B. publication-title: Blood contributor: fullname: Legendre – volume: 279 start-page: 12102 year: 2004 end-page: 12109 ident: bib52 article-title: An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation. publication-title: J Biol Chem contributor: fullname: Terraube – volume: 121 start-page: 5228 year: 2013 end-page: 5237 ident: bib40 article-title: The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels. publication-title: Blood contributor: fullname: Notley – volume: 125 start-page: 2019 year: 2015 end-page: 2028 ident: bib2 article-title: von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends. publication-title: Blood contributor: fullname: Denis – volume: 101 start-page: 3933 year: 2003 end-page: 3939 ident: bib53 article-title: Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency. publication-title: Blood contributor: fullname: Grimbergen – volume: 118 start-page: 3212 year: 2011 end-page: 3221 ident: bib63 article-title: Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor. publication-title: Blood contributor: fullname: Lane – volume: 13 start-page: 815 year: 2015 end-page: 820 ident: bib26 article-title: Shear stress-independent binding of von Willebrand factor-type 2B mutants p.R1306Q & p.V1316M to LRP1 explains their increased clearance. publication-title: J Thromb Haemost contributor: fullname: Denis – volume: 7 start-page: 71 issue: Suppl 1 year: 2009 ident: 2019111904482047700_B16 article-title: Reduced von Willebrand factor survival in von Willebrand disease: pathophysiologic and clinical relevance. publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2009.03381.x contributor: fullname: Castaman – volume: 13 start-page: 821 issue: 5 year: 2015 ident: 2019111904482047700_B24 article-title: von Willebrand factor arginine 1205 substitution results in accelerated macrophage-dependent clearance in vivo. publication-title: J Thromb Haemost doi: 10.1111/jth.12875 contributor: fullname: Rawley – volume: 279 start-page: 12102 issue: 13 year: 2004 ident: 2019111904482047700_B52 article-title: An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation. publication-title: J Biol Chem doi: 10.1074/jbc.M310436200 contributor: fullname: Lenting – volume: 3 start-page: 2228 issue: 10 year: 2005 ident: 2019111904482047700_B17 article-title: Cysteine-mutations in von Willebrand factor associated with increased clearance. publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2005.01571.x contributor: fullname: Schooten – volume: 112 start-page: 1704 issue: 5 year: 2008 ident: 2019111904482047700_B21 article-title: Macrophages contribute to the cellular uptake of von Willebrand factor and factor VIII in vivo. publication-title: Blood doi: 10.1182/blood-2008-01-133181 contributor: fullname: van Schooten – volume: 69 start-page: 1691 issue: 6 year: 1987 ident: 2019111904482047700_B36 article-title: The effect of ABO blood group on the diagnosis of von Willebrand disease. publication-title: Blood doi: 10.1182/blood.V69.6.1691.1691 contributor: fullname: Gill – volume: 109 start-page: 2430 issue: 6 year: 2007 ident: 2019111904482047700_B33 article-title: Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels. publication-title: Blood doi: 10.1182/blood-2006-06-032706 contributor: fullname: van Schooten – volume: 115 start-page: 4870 issue: 23 year: 2010 ident: 2019111904482047700_B67 article-title: Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B. publication-title: Blood doi: 10.1182/blood-2009-11-254193 contributor: fullname: Rayes – volume: 115 start-page: 2666 issue: 13 year: 2010 ident: 2019111904482047700_B13 article-title: Expression of terminal alpha2-6-linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13. publication-title: Blood doi: 10.1182/blood-2009-09-241547 contributor: fullname: McGrath – volume: 76 start-page: 1102 issue: 3 year: 1985 ident: 2019111904482047700_B4 article-title: Biosynthesis of von Willebrand protein by human megakaryocytes. publication-title: J Clin Invest doi: 10.1172/JCI112064 contributor: fullname: Sporn – volume: 14 start-page: 648 issue: 6 year: 2008 ident: 2019111904482047700_B34 article-title: The Ashwell receptor mitigates the lethal coagulopathy of sepsis. publication-title: Nat Med doi: 10.1038/nm1760 contributor: fullname: Grewal – volume: 88 start-page: 1692 issue: 5 year: 1996 ident: 2019111904482047700_B30 article-title: Clearance of normal and type 2A von Willebrand factor in the rat. publication-title: Blood doi: 10.1182/blood.V88.5.1692.1692 contributor: fullname: Stoddart – volume: 119 start-page: 2126 issue: 9 year: 2012 ident: 2019111904482047700_B23 article-title: Macrophage LRP1 contributes to the clearance of von Willebrand factor. publication-title: Blood doi: 10.1182/blood-2011-08-373605 contributor: fullname: Rastegarlari – volume: 11 start-page: 202 issue: suppl 1 year: 2013 ident: 2019111904482047700_B14 article-title: Clearance of von Willebrand factor. publication-title: J Thromb Haemost doi: 10.1111/jth.12226 contributor: fullname: Casari – volume: 125 start-page: 2019 issue: 13 year: 2015 ident: 2019111904482047700_B2 article-title: von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends. publication-title: Blood doi: 10.1182/blood-2014-06-528406 contributor: fullname: Lenting – volume: 158 start-page: 295 issue: 2 year: 1986 ident: 2019111904482047700_B10 article-title: Primary structure of a new tetraantennary glycan of the N-acetyllactosaminic type isolated from human factor VIII/von Willebrand factor. publication-title: Eur J Biochem doi: 10.1111/j.1432-1033.1986.tb09750.x contributor: fullname: Samor – volume: 99 start-page: 10042 issue: 15 year: 2002 ident: 2019111904482047700_B32 article-title: Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands. publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.142005099 contributor: fullname: Ellies – volume: 281 start-page: 1555 issue: 3 year: 2006 ident: 2019111904482047700_B49 article-title: ADAMTS13 substrate recognition of von Willebrand factor A2 domain. publication-title: J Biol Chem doi: 10.1074/jbc.M508316200 contributor: fullname: Zanardelli – volume: 108 start-page: 3344 issue: 10 year: 2006 ident: 2019111904482047700_B28 article-title: Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival. publication-title: Blood doi: 10.1182/blood-2006-04-015065 contributor: fullname: Haberichter – volume: 122 start-page: 4107 issue: 25 year: 2013 ident: 2019111904482047700_B48 article-title: Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis. publication-title: Blood doi: 10.1182/blood-2013-04-496851 contributor: fullname: McGrath – volume: 7 start-page: e45111 issue: 9 year: 2012 ident: 2019111904482047700_B59 article-title: Coagulation factor X interaction with macrophages through its N-glycans protects it from a rapid clearance. publication-title: PLoS One doi: 10.1371/journal.pone.0045111 contributor: fullname: Kurdi – volume: 124 start-page: 857 issue: 4 year: 1998 ident: 2019111904482047700_B56 article-title: Promotion of polypeptide folding by interactions with Asn-Glycans. publication-title: J Biochem doi: 10.1093/oxfordjournals.jbchem.a022190 contributor: fullname: Kimura – volume: 115 start-page: 370 issue: 2 year: 2010 ident: 2019111904482047700_B65 article-title: Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13. publication-title: Blood doi: 10.1182/blood-2009-03-210369 contributor: fullname: Wu – volume: 13 start-page: 815 issue: 5 year: 2015 ident: 2019111904482047700_B26 article-title: Shear stress-independent binding of von Willebrand factor-type 2B mutants p.R1306Q & p.V1316M to LRP1 explains their increased clearance. publication-title: J Thromb Haemost doi: 10.1111/jth.12885 contributor: fullname: Wohner – volume: 123 start-page: 5071 issue: 12 year: 2013 ident: 2019111904482047700_B27 article-title: von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin αIIbβ3. publication-title: J Clin Invest doi: 10.1172/JCI69458 contributor: fullname: Casari – volume: 46 start-page: 1836 issue: 10 year: 2006 ident: 2019111904482047700_B5 article-title: ABO blood group determines plasma von Willebrand factor levels: a biologic function after all? publication-title: Transfusion doi: 10.1111/j.1537-2995.2006.00975.x contributor: fullname: Jenkins – volume: 8 start-page: 137 issue: 1 year: 2010 ident: 2019111904482047700_B8 article-title: The plasma von Willebrand factor O-glycome comprises a surprising variety of structures including ABH antigens and disialosyl motifs. publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2009.03665.x contributor: fullname: Canis – volume: 10 start-page: 1929 issue: 9 year: 2012 ident: 2019111904482047700_B22 article-title: Shear stress is required for the endocytic uptake of the factor VIII-von Willebrand factor complex by macrophages. publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2012.04860.x contributor: fullname: Castro-Núñez – volume: 5 start-page: e8668 issue: 1 year: 2010 ident: 2019111904482047700_B50 article-title: The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages. publication-title: PLoS One doi: 10.1371/journal.pone.0008668 contributor: fullname: Daigneault – volume: 447 start-page: 217 issue: 2 year: 2012 ident: 2019111904482047700_B7 article-title: Mapping the N-glycome of human von Willebrand factor. publication-title: Biochem J doi: 10.1042/BJ20120810 contributor: fullname: Canis – volume: 32 start-page: 894 issue: 4 year: 2012 ident: 2019111904482047700_B38 article-title: Identification of galectin-1 and galectin-3 as novel partners for von Willebrand factor. publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.111.240309 contributor: fullname: Saint-Lu – volume: 13 start-page: 592 issue: 4 year: 2015 ident: 2019111904482047700_B25 article-title: No evidence for a direct effect of von Willebrand factor’s ABH blood group antigens on von Willebrand factor clearance. publication-title: J Thromb Haemost doi: 10.1111/jth.12867 contributor: fullname: Groeneveld – volume: 148 start-page: 834 issue: 6 year: 2010 ident: 2019111904482047700_B47 article-title: Platelet von Willebrand factor--structure, function and biological importance. publication-title: Br J Haematol doi: 10.1111/j.1365-2141.2009.08052.x contributor: fullname: McGrath – volume: 121 start-page: 5228 issue: 26 year: 2013 ident: 2019111904482047700_B40 article-title: The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels. publication-title: Blood doi: 10.1182/blood-2012-10-457507 contributor: fullname: Rydz – volume: 117 start-page: 4358 issue: 16 year: 2011 ident: 2019111904482047700_B19 article-title: Pathologic mechanisms of type 1 VWD mutations R1205H and Y1584C through in vitro and in vivo mouse models. publication-title: Blood doi: 10.1182/blood-2010-08-303727 contributor: fullname: Pruss – volume: 101 start-page: 3933 issue: 10 year: 2003 ident: 2019111904482047700_B53 article-title: Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency. publication-title: Blood doi: 10.1182/blood-2002-07-2081 contributor: fullname: Bovenschen – ident: 2019111904482047700_B37 contributor: fullname: Harris – volume: 151 start-page: 22 issue: 1 year: 1983 ident: 2019111904482047700_B9 article-title: Structure determination of the major asparagine-linked sugar chain of human factor VIII--von Willebrand factor. publication-title: FEBS Lett doi: 10.1016/0014-5793(83)80334-2 contributor: fullname: Debeire – volume: 25 start-page: 3171 issue: 11 year: 1986 ident: 2019111904482047700_B6 article-title: Amino acid sequence of human von Willebrand factor. publication-title: Biochemistry doi: 10.1021/bi00359a015 contributor: fullname: Titani – volume: 267 start-page: 8723 issue: 13 year: 1992 ident: 2019111904482047700_B11 article-title: Structures of the asparagine-linked oligosaccharide chains of human von Willebrand factor. Occurrence of blood group A, B, and H(O) structures. publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)50338-6 contributor: fullname: Matsui – volume: 96 start-page: 111 issue: 1 year: 1999 ident: 2019111904482047700_B31 article-title: Mvwf, a dominant modifier of murine von Willebrand factor, results from altered lineage-specific expression of a glycosyltransferase. publication-title: Cell doi: 10.1016/S0092-8674(00)80964-2 contributor: fullname: Mohlke – volume: 7 start-page: e37508 issue: 5 year: 2012 ident: 2019111904482047700_B58 article-title: In vivo analysis of the role of O-glycosylations of von Willebrand factor. publication-title: PLoS One doi: 10.1371/journal.pone.0037508 contributor: fullname: Badirou – volume: 45 start-page: 97 issue: 2 year: 1989 ident: 2019111904482047700_B51 article-title: Macrophage subset repopulation in the spleen: differential kinetics after liposome-mediated elimination. publication-title: J Leukoc Biol doi: 10.1002/jlb.45.2.97 contributor: fullname: van Rooijen – volume: 324 start-page: 1330 issue: 5932 year: 2009 ident: 2019111904482047700_B66 article-title: Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor. publication-title: Science doi: 10.1126/science.1170905 contributor: fullname: Zhang – volume: 6 start-page: 263 issue: 3 year: 1989 ident: 2019111904482047700_B12 article-title: Primary structure of the major O-glycosidically linked carbohydrate unit of human von Willebrand factor. publication-title: Glycoconj J doi: 10.1007/BF01047846 contributor: fullname: Samor – volume: 99 start-page: 180 issue: 1 year: 2002 ident: 2019111904482047700_B15 article-title: Reduced von Willebrand factor survival in type Vicenza von Willebrand disease. publication-title: Blood doi: 10.1182/blood.V99.1.180 contributor: fullname: Casonato – volume: 97 start-page: 1855 issue: 12 year: 2012 ident: 2019111904482047700_B39 article-title: Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5. publication-title: Haematologica doi: 10.3324/haematol.2012.063297 contributor: fullname: Pegon – volume: 122 start-page: 3735 issue: 23 year: 2013 ident: 2019111904482047700_B1 article-title: von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy. publication-title: Blood doi: 10.1182/blood-2013-06-498303 contributor: fullname: Lillicrap – volume: 7 start-page: 2096 issue: 12 year: 2009 ident: 2019111904482047700_B45 article-title: Shear-induced unfolding activates von Willebrand factor A2 domain for proteolysis. publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2009.03640.x contributor: fullname: Baldauf – volume: 121 start-page: 3801 issue: 19 year: 2013 ident: 2019111904482047700_B62 article-title: Elucidating the role of carbohydrate determinants in regulating hemostasis: insights and opportunities. publication-title: Blood doi: 10.1182/blood-2012-10-415000 contributor: fullname: Preston – volume: 111 start-page: 4979 issue: 10 year: 2008 ident: 2019111904482047700_B18 article-title: Identification of type 1 von Willebrand disease patients with reduced von Willebrand factor survival by assay of the VWF propeptide in the European study: molecular and clinical markers for the diagnosis and management of type 1 VWD (MCMDM-1VWD). publication-title: Blood doi: 10.1182/blood-2007-09-110940 contributor: fullname: Haberichter – volume: 115 start-page: 4910 issue: 23 year: 2010 ident: 2019111904482047700_B46 article-title: The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function. publication-title: Blood doi: 10.1182/blood-2009-12-257949 contributor: fullname: Luken – volume: 118 start-page: 3212 issue: 12 year: 2011 ident: 2019111904482047700_B63 article-title: Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor. publication-title: Blood doi: 10.1182/blood-2011-02-306597 contributor: fullname: Crawley – volume: 99 start-page: 2123 issue: 6 year: 1984 ident: 2019111904482047700_B3 article-title: Biosynthesis of von Willebrand protein by human endothelial cells: processing steps and their intracellular localization. publication-title: J Cell Biol doi: 10.1083/jcb.99.6.2123 contributor: fullname: Wagner – volume: 269 start-page: 1273 issue: 5228 year: 1995 ident: 2019111904482047700_B55 article-title: Conformation and function of the N-linked glycan in the adhesion domain of human CD2. publication-title: Science doi: 10.1126/science.7544493 contributor: fullname: Wyss – volume: 31 start-page: 156 issue: 3 year: 2006 ident: 2019111904482047700_B57 article-title: N-linked oligosaccharides as outfitters for glycoprotein folding, form and function. publication-title: Trends Biochem Sci doi: 10.1016/j.tibs.2006.01.003 contributor: fullname: Mitra – volume: 252 start-page: 5538 issue: 15 year: 1977 ident: 2019111904482047700_B29 article-title: Relationship of sialic acid to function and in vivo survival of human factor VIII/von Willebrand factor protein. publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)63384-3 contributor: fullname: Sodetz – volume: 121 start-page: 2336 issue: 12 year: 2013 ident: 2019111904482047700_B20 article-title: VWF propeptide and ratios between VWF, VWF propeptide, and FVIII in the characterization of type 1 von Willebrand disease. publication-title: Blood doi: 10.1182/blood-2012-09-455089 contributor: fullname: Eikenboom – volume: 116 start-page: 640 issue: 4 year: 2010 ident: 2019111904482047700_B43 article-title: Specific N-linked glycosylation sites modulate synthesis and secretion of von Willebrand factor. publication-title: Blood doi: 10.1182/blood-2010-02-267450 contributor: fullname: McKinnon – volume: 466 start-page: 992 issue: 7309 year: 2010 ident: 2019111904482047700_B64 article-title: A mechanically stabilized receptor-ligand flex-bond important in the vasculature. publication-title: Nature doi: 10.1038/nature09295 contributor: fullname: Kim – volume: 111 start-page: 3042 issue: 6 year: 2008 ident: 2019111904482047700_B42 article-title: N-linked glycosylation of VWF modulates its interaction with ADAMTS13. publication-title: Blood doi: 10.1182/blood-2007-06-095042 contributor: fullname: McKinnon – volume: 108 start-page: 3746 issue: 12 year: 2006 ident: 2019111904482047700_B60 article-title: P-selectin glycoprotein ligand 1 and beta2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor. publication-title: Blood doi: 10.1182/blood-2006-03-010322 contributor: fullname: Pendu – volume: 8 start-page: 2338 issue: 10 year: 2010 ident: 2019111904482047700_B61 article-title: von Willebrand factor clearance does not involve proteolysis by ADAMTS-13. publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2010.04012.x contributor: fullname: Badirou – volume: 111 start-page: 3540 issue: 7 year: 2008 ident: 2019111904482047700_B35 article-title: A shorter von Willebrand factor survival in O blood group subjects explains how ABO determinants influence plasma von Willebrand factor. publication-title: Blood doi: 10.1182/blood-2007-11-122945 contributor: fullname: Gallinaro – volume: 266 start-page: 23022 issue: 34 year: 1991 ident: 2019111904482047700_B54 article-title: The effect of carbohydrate on the structure and stability of erythropoietin. publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)54457-4 contributor: fullname: Narhi – volume: 127 start-page: 1711 issue: 13 year: 2016 ident: 2019111904482047700_B44 article-title: N-linked glycan stabilization of the VWF A2 domain. publication-title: Blood doi: 10.1182/blood-2015-09-672014 contributor: fullname: Lynch – volume: 121 start-page: 1382 issue: 12 year: 2010 ident: 2019111904482047700_B41 article-title: Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.109.869156 contributor: fullname: Smith |
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Snippet | Enhanced von Willebrand factor (VWF) clearance is important in the etiology of von Willebrand disease. However, the molecular mechanisms underlying VWF... Key Points The A1 domain of VWF contains a cryptic binding site that plays a key role in regulating macrophage binding and clearance. The N-linked glycans... |
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StartPage | 1959 |
SubjectTerms | Amino Acid Substitution Animals Cell Line, Tumor Humans Macrophages - cytology Macrophages - metabolism Mice Mice, Knockout Mutation, Missense Polysaccharides - chemistry Polysaccharides - genetics Polysaccharides - metabolism Protein Domains von Willebrand Factor - chemistry von Willebrand Factor - genetics von Willebrand Factor - metabolism |
Title | N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance |
URI | https://dx.doi.org/10.1182/blood-2016-04-709436 https://www.ncbi.nlm.nih.gov/pubmed/27554083 |
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