A plasma membrane localized protein phosphatase in Toxoplasma gondii, PPM5C, regulates attachment to host cells

• Published in: Scientific reports Vol. 9; no. 1; p. 5924
• Main Authors: Yang, Chunlin, Broncel, Malgorzata, Dominicus, Caia, Sampson, Emily, Blakely, William J., Treeck, Moritz, Arrizabalaga, Gustavo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.04.2019; Nature Publishing Group
• Subjects: 13/109; 14/34; 42/70; 631/326/417/1716; 631/337/458/1733; 82/29; 82/58; Calcium; Calcium Signaling; Cell culture; Cell Membrane - metabolism; Cell Membrane - parasitology; Cell-Matrix Junctions - metabolism; Cell-Matrix Junctions - parasitology; Clonal deletion; Fibroblasts - metabolism; Fibroblasts - parasitology; Host-Parasite Interactions; Humanities and Social Sciences; Humans; Kinases; Localization; Membrane proteins; Membranes; multidisciplinary; Parasite attachment; Parasites; Parasitophorous vacuole; Phenotypes; Phosphatase; Phosphoprotein Phosphatases - genetics; Phosphoprotein Phosphatases - metabolism; Phosphorylation; Propagation; Protein kinase; Protein phosphatase; Proteins; Protozoan Proteins - genetics; Protozoan Proteins - metabolism; Science; Science (multidisciplinary); Tissue culture; Toxoplasma - metabolism; Toxoplasma gondii; Toxoplasmosis - metabolism; Toxoplasmosis - parasitology

The propagation of Toxoplasma gondii is accomplished by repeated lytic cycles of parasite attachment to a host cell, invasion, replication within a parasitophorous vacuole, and egress from the cell. This lytic cycle is delicately regulated by calcium-dependent reversible phosphorylation of the molec...