Investigating the Structure of Neurotoxic Protein Aggregates Inside Cells

• Published in: Trends in cell biology Vol. 30; no. 12; pp. 951 - 966
• Main Authors: Bäuerlein, Felix J.B., Fernández-Busnadiego, Rubén, Baumeister, Wolfgang
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2020; Elsevier BV
• Subjects: Aggregates; Aging; Cellular structure; cryo-electron tomography; Disease; Electron microscopy; Huntingtin; Huntington's disease; Huntingtons disease; inclusion bodies; Light microscopy; Medical treatment; Microscopy; neurodegeneration; Neurodegenerative diseases; Neurotoxicity; Optical microscopy; protein aggregation; Protein structure; Proteins; super-resolution light microscopy; super-resolution light microscopy; neurodegeneration; electron microscopy; inclusion bodies; cryo-electron tomography; protein aggregation

Neurodegenerative diseases affect the lives of millions of people across the world, being particularly prevalent in the aging population. Despite huge research efforts, conclusive insights into the disease mechanisms are still lacking. Therefore, therapeutic strategies are limited to symptomatic tre...