LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity - Krishnamurty, Akshay T.; Shyer, Justin A.; Thai, Minh; Gandham, Vineela; Buechler, Matthew B.; Yang, Yeqing Angela; Pradhan, Rachana N.; Wang, Amber W.; Sanchez, Patricia L.; Qu, Yan; Breart, Beatrice; Chalouni, Cécile; et al. (Nature (London), 2022)
Keywords: 13/1; 13/106; 13/31; 14/63; 38/39; 38/91; 59; 631/250/2520; 631/250/580/1884; 631/67/1059/2325; 631/67/327; 631/67/580; 64/60; Animal models; Animals; B7-H1 Antigen; Cancer; Cancer-Associated Fibroblasts - metabolism; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Depletion; Diphtheria; Diphtheria toxin; Effector cells; Extracellular matrix; Fibroblasts; Gene expression; Humanities and Social Sciences; Humans; Immune checkpoint; Immunity; Immunotherapy; Leucine; Lymphocytes; Lymphocytes T; Membrane Proteins - metabolism; Mice; multidisciplinary; Myofibroblasts - metabolism; Pancreatic cancer; Pancreatic Neoplasms - immunology; Pancreatic Neoplasms - pathology; Population; Receptors; Receptors, Transforming Growth Factor beta; Science; Science (multidisciplinary); Stromal Cells; Toxins; Transforming Growth Factor beta - metabolism; Tumor Microenvironment; Tumors