G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2

• Published in: Blood Vol. 129; no. 5; pp. 587 - 597
• Main Authors: Kawano, Yuko, Fukui, Chie, Shinohara, Masakazu, Wakahashi, Kanako, Ishii, Shinichi, Suzuki, Tomohide, Sato, Mari, Asada, Noboru, Kawano, Hiroki, Minagawa, Kentaro, Sada, Akiko, Furuyashiki, Tomoyuki, Uematsu, Satoshi, Akira, Shizuo, Uede, Toshimitsu, Narumiya, Shuh, Matsui, Toshimitsu, Katayama, Yoshio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.02.2017
• Subjects: Adrenergic beta-Agonists - pharmacology; Animals; Bone Marrow Cells - cytology; Bone Marrow Cells - drug effects; Bone Marrow Cells - metabolism; Cell Line; Dinoprostone - metabolism; Fever - chemically induced; Fever - genetics; Gene Deletion; Granulocyte Colony-Stimulating Factor - administration & dosage; Granulocyte Colony-Stimulating Factor - adverse effects; Granulocyte Colony-Stimulating Factor - pharmacology; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - drug effects; Hematopoietic Stem Cells - metabolism; Male; Mice, Inbred C57BL; Neutrophils - cytology; Neutrophils - drug effects; Neutrophils - metabolism; Prostaglandin-E Synthases - genetics; Prostaglandin-E Synthases - metabolism; Receptors, Adrenergic, beta - metabolism

Granulocyte colony-stimulating factor (G-CSF) is widely used for peripheral blood stem/progenitor mobilization. G-CSF causes low-grade fever that is ameliorated by nonsteroidal anti-inflammatory drugs (NSAIDs), suggesting the activation of arachidonic acid (AA) cascade. How G-CSF regulated this reac...