Creatine supplementation in Walker-256 tumor-bearing rats prevents skeletal muscle atrophy by attenuating systemic inflammation and protein degradation signaling

• Published in: European journal of nutrition Vol. 59; no. 2; pp. 661 - 669
• Main Authors: Cella, Paola S., Marinello, Poliana C., Borges, Fernando H., Ribeiro, Diogo F., Chimin, Patrícia, Testa, Mayra T. J., Guirro, Philippe B., Duarte, José A., Cecchini, Rubens, Guarnier, Flávia A., Deminice, Rafael
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2020; Springer Nature B.V
• Subjects: Animals; Atrophy; Body weight; body weight changes; Body weight loss; Carcinoma 256, Walker - metabolism; Chemistry; Chemistry and Materials Science; Creatine; Creatine - administration & dosage; Creatine - pharmacology; Dietary Supplements; Disease Models, Animal; Drinking water; Food intake; Immunoblotting; Inflammation; Inflammation - prevention & control; Interleukin 6; laboratory animals; Male; Muscle, Skeletal - drug effects; muscular atrophy; Muscular Atrophy - prevention & control; Musculoskeletal system; neoplasm cells; neoplasms; Nutrition; Original Contribution; Oxidative stress; Proteasomes; protein degradation; Proteolysis; Proteolysis - drug effects; pulp; quantitative polymerase chain reaction; Rats; Rats, Wistar; Signal Transduction - drug effects; Skeletal muscle; Spleen; T cell receptors; Tumor cells; tumor necrosis factor-alpha; Tumor necrosis factor-α; Ubiquitin; Water intake; White pulp; Oxidative stress; Cachexia; Proteolysis; Muscle loss; Cancer

Purpose The aim of this study was to investigate the effects of creatine supplementation on muscle wasting in Walker-256 tumor-bearing rats. Methods Wistar rats were randomly assigned into three groups ( n  = 10/group): control (C), tumor bearing (T), and tumor bearing supplemented with creatine (TC...