Aquaporin-4 in Neuromyelitis Optica Spectrum Disorders: A Target of Autoimmunity in the Central Nervous System

Since the discovery of a specific autoantibody in patients with neuromyelitis optica spectrum disorder (NMOSD) in 2004, the water channel aquaporin-4 (AQP4) has attracted attention as a target of autoimmune diseases of the central nervous system. In NMOSD, the autoantibody (NMO-IgG) binds to the ext...

Full description

Saved in:
Bibliographic Details
Published inBiomolecules (Basel, Switzerland) Vol. 12; no. 4; p. 591
Main Authors Abe, Yoichiro, Yasui, Masato
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 17.04.2022
MDPI
Subjects
Amino acids
Aquaporin 4
Aquaporin 4 - metabolism
aquaporin-4 (AQP4)
Aquaporins
Astrocytes
Autoantibodies
Autoimmune diseases
Autoimmunity
Central nervous system
Central Nervous System - metabolism
Complement System Proteins - metabolism
Cytotoxicity
Demyelinating diseases
Demyelination
Endocytosis
Humans
Immunoglobulin G
Localization
Multiple sclerosis
Musculoskeletal system
Nervous system
Neuromyelitis
Neuromyelitis Optica - metabolism
Neuromyelitis Optica - pathology
neuromyelitis optica spectrum disorders (NMOSD)
NMO-IgG
Orthogonal arrays of particles (OAPs)
Pathogenesis
Peptides
Review
astrocytes
aquaporin-4 (AQP4)
NMO-IgG
neuromyelitis optica spectrum disorders (NMOSD)
Orthogonal arrays of particles (OAPs)
Online AccessGet full text

Cover

Abstract Since the discovery of a specific autoantibody in patients with neuromyelitis optica spectrum disorder (NMOSD) in 2004, the water channel aquaporin-4 (AQP4) has attracted attention as a target of autoimmune diseases of the central nervous system. In NMOSD, the autoantibody (NMO-IgG) binds to the extracellular loops of AQP4 as expressed in perivascular astrocytic end-feet and disrupts astrocytes in a complement-dependent manner. NMO-IgG is an excellent marker for distinguishing the disease from other inflammatory demyelinating diseases, such as multiple sclerosis. The unique higher-order structure of AQP4—called orthogonal arrays of particles (OAPs)—as well as its subcellular localization may play a crucial role in the pathogenesis of the disease. Recent studies have also demonstrated complement-independent cytotoxic effects of NMO-IgG. Antibody-induced endocytosis of AQP4 has been suggested to be involved in this mechanism. This review focuses on the binding properties of antibodies that recognize the extracellular region of AQP4 and the characteristics of AQP4 that are implicated in the pathogenesis of NMOSD.
AbstractList Since the discovery of a specific autoantibody in patients with neuromyelitis optica spectrum disorder (NMOSD) in 2004, the water channel aquaporin-4 (AQP4) has attracted attention as a target of autoimmune diseases of the central nervous system. In NMOSD, the autoantibody (NMO-IgG) binds to the extracellular loops of AQP4 as expressed in perivascular astrocytic end-feet and disrupts astrocytes in a complement-dependent manner. NMO-IgG is an excellent marker for distinguishing the disease from other inflammatory demyelinating diseases, such as multiple sclerosis. The unique higher-order structure of AQP4—called orthogonal arrays of particles (OAPs)—as well as its subcellular localization may play a crucial role in the pathogenesis of the disease. Recent studies have also demonstrated complement-independent cytotoxic effects of NMO-IgG. Antibody-induced endocytosis of AQP4 has been suggested to be involved in this mechanism. This review focuses on the binding properties of antibodies that recognize the extracellular region of AQP4 and the characteristics of AQP4 that are implicated in the pathogenesis of NMOSD.
Since the discovery of a specific autoantibody in patients with neuromyelitis optica spectrum disorder (NMOSD) in 2004, the water channel aquaporin-4 (AQP4) has attracted attention as a target of autoimmune diseases of the central nervous system. In NMOSD, the autoantibody (NMO-IgG) binds to the extracellular loops of AQP4 as expressed in perivascular astrocytic end-feet and disrupts astrocytes in a complement-dependent manner. NMO-IgG is an excellent marker for distinguishing the disease from other inflammatory demyelinating diseases, such as multiple sclerosis. The unique higher-order structure of AQP4-called orthogonal arrays of particles (OAPs)-as well as its subcellular localization may play a crucial role in the pathogenesis of the disease. Recent studies have also demonstrated complement-independent cytotoxic effects of NMO-IgG. Antibody-induced endocytosis of AQP4 has been suggested to be involved in this mechanism. This review focuses on the binding properties of antibodies that recognize the extracellular region of AQP4 and the characteristics of AQP4 that are implicated in the pathogenesis of NMOSD.Since the discovery of a specific autoantibody in patients with neuromyelitis optica spectrum disorder (NMOSD) in 2004, the water channel aquaporin-4 (AQP4) has attracted attention as a target of autoimmune diseases of the central nervous system. In NMOSD, the autoantibody (NMO-IgG) binds to the extracellular loops of AQP4 as expressed in perivascular astrocytic end-feet and disrupts astrocytes in a complement-dependent manner. NMO-IgG is an excellent marker for distinguishing the disease from other inflammatory demyelinating diseases, such as multiple sclerosis. The unique higher-order structure of AQP4-called orthogonal arrays of particles (OAPs)-as well as its subcellular localization may play a crucial role in the pathogenesis of the disease. Recent studies have also demonstrated complement-independent cytotoxic effects of NMO-IgG. Antibody-induced endocytosis of AQP4 has been suggested to be involved in this mechanism. This review focuses on the binding properties of antibodies that recognize the extracellular region of AQP4 and the characteristics of AQP4 that are implicated in the pathogenesis of NMOSD.
Author Yasui, Masato
Abe, Yoichiro
AuthorAffiliation 1 Department of Pharmacology, Keio University School of Medicine, Tokyo 160-8582, Japan
2 Keio University Global Research Institute, Tokyo 108-8345, Japan
AuthorAffiliation_xml – name: 2 Keio University Global Research Institute, Tokyo 108-8345, Japan
– name: 1 Department of Pharmacology, Keio University School of Medicine, Tokyo 160-8582, Japan
Author_xml – sequence: 1
  givenname: Yoichiro
  orcidid: 0000-0001-6163-8794
  surname: Abe
  fullname: Abe, Yoichiro
– sequence: 2
  givenname: Masato
  surname: Yasui
  fullname: Yasui, Masato
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35454180$$D View this record in MEDLINE/PubMed
BookMark eNptkktr3DAQgEVJadI0t56LoJce6lYv23IPhWX7CoTmkBR6E7I03mixLUeSA_vvK3fTsAkVAgnp08fMaF6io9GPgNBrSj5w3pCPrfMDZUSQsqHP0AljVBas5r-PDvbH6CzGLclD5sn4C3TMS1EKKskJGle3s558cGMhsBvxT5iDH3bQu-QivpySMxpfTWBSmAf8xUUfLIT4Ca_wtQ4bSNh3eDUn74ZhHl3aLZJ0A3gNYwq6z8Jw5-eIr3YxwfAKPe90H-Hsfj1Fv759vV7_KC4uv5-vVxeFEbVIRVlKLo0mJUjDalJXmlhupCFCSAFSS1nJ2nZVxauSsoZZSzVnhrXSUtHWgp-i873Xer1VU3CDDjvltVN_D3zYKB1ybj2oznLddrKptbHCANW2AQGagIGacCaz6_PeNc3tANbsE3skfXwzuhu18XeqIZyUkmbBu3tB8LczxKQGFw30vR4hl0axqhSsacpqQd8-Qbd-DmMu1UKxzBDJM_XmMKKHUP59awbe7wETfIwBugeEErU0jjpsnIyzJ7hxSSfnl3xc__9HfwBosMcX
CitedBy_id crossref_primary_10_1002_ccr3_70095
crossref_primary_10_1002_ibra_12062
crossref_primary_10_1039_D3RA03989G
crossref_primary_10_14412_2074_2711_2024_2S_65_73
crossref_primary_10_3390_ijms23147908
crossref_primary_10_22730_jmls_2022_19_3_130
crossref_primary_10_1038_s41598_023_45457_w
crossref_primary_10_7759_cureus_31334
crossref_primary_10_3390_app13085029
crossref_primary_10_1002_brb3_3433
crossref_primary_10_3390_ijms26031330
crossref_primary_10_1111_febs_16717
crossref_primary_10_1016_j_jns_2024_123041
crossref_primary_10_1016_j_msard_2024_105803
crossref_primary_10_4103_NRR_NRR_D_23_01325
crossref_primary_10_17816_RCF21135_48
crossref_primary_10_1177_07487304221146242
crossref_primary_10_1021_acs_biochem_3c00688
crossref_primary_10_17816_RCF321506
crossref_primary_10_1007_s11064_023_04067_8
Cites_doi 10.1007/s00401-018-1950-8
10.1074/jbc.271.9.4577
10.1371/journal.pone.0010455
10.1038/s41582-021-00568-8
10.1242/jcs.110.22.2855
10.1152/ajpcell.00182.2014
10.1093/brain/awm047
10.1073/pnas.91.26.13052
10.1021/bi802231q
10.1002/ana.22551
10.1074/jbc.M110.144576
10.1242/jcs.108.9.2993
10.1007/s00401-013-1172-z
10.1074/jbc.M111.280701
10.1002/glia.20661
10.1046/j.1460-9568.1998.00360.x
10.1073/pnas.92.10.4328
10.1074/jbc.270.39.22907
10.1186/s40478-019-0707-5
10.1007/s12035-021-02491-x
10.1016/j.ygeno.2007.12.003
10.1002/glia.23126
10.1212/WNL.0000000000001729
10.3390/ijms21041531
10.1074/jbc.M112.344325
10.1083/jcb.147.3.645
10.1203/00006450-200009000-00012
10.1002/glia.22635
10.1016/S0021-9258(17)37486-0
10.1074/jbc.M110.123000
10.1016/j.mcn.2013.02.002
10.1084/jem.20050304
10.1007/s00415-020-10235-5
10.1186/s40478-019-0766-7
10.1084/jem.20081241
10.1002/glia.22417
10.1083/jcb.200106158
10.1074/jbc.M109.071670
10.1152/ajprenal.00439.2003
10.1016/j.jim.2007.02.005
10.1212/01.WNL.0000289761.64862.ce
10.1016/j.jmb.2005.10.081
10.1093/brain/awl371
10.4049/jimmunol.181.8.5730
10.1074/jbc.M111.227298
10.1073/pnas.2235843100
10.1111/j.1471-4159.2008.05302.x
10.1002/glia.20855
10.1073/pnas.1109980108
10.1006/geno.1997.4641
10.1111/j.1471-4159.2012.07652.x
10.1152/ajpcell.2000.278.6.C1108
10.1152/ajpcell.1997.273.5.C1549
10.1016/j.jneuroim.2009.04.001
10.1073/pnas.95.20.11981
10.1016/0014-5793(96)00092-0
10.1002/glia.21177
10.1016/j.neuroscience.2010.02.008
10.1073/pnas.241508198
10.1006/geno.1996.0214
10.1016/j.bbrc.2008.09.155
10.1091/mbc.e13-06-0331
10.1016/j.jneuroim.2009.07.014
10.1242/jcs.042341
10.1016/S0140-6736(04)17551-X
10.1172/JCI67554
10.1152/ajpcell.1999.276.3.C621
10.1093/brain/awp309
10.1093/brain/awq177
10.1186/s12974-021-02249-1
10.1021/bi702146k
10.1186/s40478-015-0259-2
10.1073/pnas.93.20.10908
10.1021/bi990941s
10.1002/ana.21837
10.1016/j.bbamem.2007.12.007
10.1002/ana.21802
10.1002/glia.21234
10.1074/jbc.M109.069245
10.1073/pnas.1701960114
10.1523/JNEUROSCI.18-07-02506.1998
10.1111/bph.13340
10.1016/j.bbrc.2014.08.026
10.1172/JCI2545
10.1002/ana.22657
10.1111/j.1600-0854.2011.01299.x
10.1089/mab.2013.0007
10.1152/physrev.00031.2020
10.1016/S0014-5793(99)01256-9
10.1523/JNEUROSCI.17-01-00171.1997
10.1186/s12974-018-1333-z
10.1111/j.1460-9568.1996.tb01568.x
10.1002/glia.24032
10.1002/1873-3468.12910
10.1016/j.jneuroim.2013.03.003
10.1016/j.neuropharm.2019.107827
10.1007/s00401-017-1734-6
10.1083/jcb.145.2.391
10.1091/mbc.e08-03-0322
10.1002/glia.23909
10.1016/j.bbrc.2009.06.085
10.1016/j.jaut.2012.07.008
10.1007/s00401-012-0986-4
ContentType Journal Article
Copyright 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2022 by the authors. 2022
Copyright_xml – notice: 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2022 by the authors. 2022
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7T5
7TM
7TO
7X7
7XB
88E
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.3390/biom12040591
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Immunology Abstracts
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Journals
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
AIDS and Cancer Research Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Immunology Abstracts
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
Publicly Available Content Database

CrossRef
MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 2218-273X
ExternalDocumentID oai_doaj_org_article_fd3abf897acd4ce1ad9e4ea0ece70328
PMC9030581
35454180
10_3390_biom12040591
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID 53G
5VS
7X7
88E
8FE
8FH
8FI
8FJ
AADQD
AAFWJ
AAYXX
ABDBF
ABUWG
ACUHS
ADBBV
AFKRA
AFPKN
AFZYC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
CCPQU
CITATION
EBD
ESX
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HYE
IAO
IHR
ITC
KQ8
LK8
M1P
M48
M7P
MODMG
M~E
OK1
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
RPM
UKHRP
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7T5
7TM
7TO
7XB
8FK
AZQEC
DWQXO
GNUQQ
H94
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c474t-55838ca05e8c27076a0d3c8c04484e8a88687df663651292dd1a32c2b8d14b743
IEDL.DBID 7X7
ISSN 2218-273X
IngestDate Wed Aug 27 01:20:56 EDT 2025
Thu Aug 21 13:44:41 EDT 2025
Fri Jul 11 09:53:03 EDT 2025
Fri Jul 25 11:54:56 EDT 2025
Thu Apr 03 07:00:14 EDT 2025
Tue Jul 01 02:05:36 EDT 2025
Thu Apr 24 23:08:30 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords astrocytes
aquaporin-4 (AQP4)
NMO-IgG
neuromyelitis optica spectrum disorders (NMOSD)
Orthogonal arrays of particles (OAPs)
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c474t-55838ca05e8c27076a0d3c8c04484e8a88687df663651292dd1a32c2b8d14b743
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0001-6163-8794
OpenAccessLink https://www.proquest.com/docview/2652956083?pq-origsite=%requestingapplication%
PMID 35454180
PQID 2652956083
PQPubID 2032425
ParticipantIDs doaj_primary_oai_doaj_org_article_fd3abf897acd4ce1ad9e4ea0ece70328
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9030581
proquest_miscellaneous_2654299561
proquest_journals_2652956083
pubmed_primary_35454180
crossref_primary_10_3390_biom12040591
crossref_citationtrail_10_3390_biom12040591
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20220417
PublicationDateYYYYMMDD 2022-04-17
PublicationDate_xml – month: 4
  year: 2022
  text: 20220417
  day: 17
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Biomolecules (Basel, Switzerland)
PublicationTitleAlternate Biomolecules
PublicationYear 2022
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References Lu (ref_54) 1996; 93
Vincent (ref_19) 2008; 18
Hinson (ref_27) 2017; 114
Crane (ref_95) 2011; 286
Nicchia (ref_69) 2008; 56
ref_98
Rossi (ref_74) 2011; 59
Frigeri (ref_33) 1995; 92
Huang (ref_83) 2016; 7
Nicchia (ref_52) 2010; 168
Pisani (ref_82) 2011; 59
Nielsen (ref_44) 1997; 17
Crane (ref_107) 2008; 19
Abe (ref_78) 2017; 591
Fujita (ref_41) 1999; 459
Bradl (ref_5) 2009; 66
Terris (ref_32) 1995; 269
Hinson (ref_4) 2007; 69
Tradtrantip (ref_17) 2017; 134
Phuan (ref_99) 2012; 287
Hiroaki (ref_47) 2006; 355
Rash (ref_50) 1998; 95
Zelenin (ref_75) 2000; 48
Furman (ref_56) 2003; 100
Turtzo (ref_55) 1997; 41
Ma (ref_73) 1996; 33
Sepramaniam (ref_87) 2010; 285
Palazzo (ref_85) 2019; 7
Takumi (ref_39) 1998; 10
Nielsen (ref_36) 1997; 273
Hinson (ref_25) 2008; 205
Hasegawa (ref_30) 1994; 269
Rasmussen (ref_45) 2021; 102
Ratelade (ref_22) 2013; 126
Netti (ref_93) 2021; 58
Howe (ref_28) 2014; 62
Assentoft (ref_89) 2014; 307
Yang (ref_42) 2000; 278
Alikina (ref_76) 2012; 77
Marignier (ref_26) 2010; 133
Kadohira (ref_88) 2008; 377
Hinson (ref_100) 2012; 109
Miyazaki (ref_92) 2013; 260
Saitoh (ref_103) 2007; 322
Saadoun (ref_9) 2010; 133
Pisani (ref_64) 2021; 69
Kinoshita (ref_7) 2009; 386
Jung (ref_31) 1994; 91
Blake (ref_66) 1999; 147
Tani (ref_94) 2009; 211
Hillebrand (ref_11) 2019; 137
Yang (ref_48) 1996; 271
ref_86
Neely (ref_46) 1999; 38
Contentti (ref_16) 2021; 18
Misaka (ref_35) 1996; 381
Pisani (ref_96) 2011; 286
Rossi (ref_81) 2010; 285
Moe (ref_72) 2008; 91
Kato (ref_43) 2014; 451
Silberstein (ref_57) 2004; 287
Nicchia (ref_68) 2008; 105
Abe (ref_77) 2012; 120
Adams (ref_70) 2001; 155
Abe (ref_105) 2013; 56
Bennett (ref_6) 2009; 66
Takai (ref_104) 2016; 173
Zhang (ref_21) 2013; 123
Pisani (ref_84) 2017; 65
Tian (ref_65) 1997; 8
Rossi (ref_62) 2012; 13
Lennon (ref_3) 2005; 202
Sabater (ref_8) 2009; 215
Frigeri (ref_34) 1995; 108
Crane (ref_60) 2009; 284
Pittocks (ref_14) 2021; 17
Iorio (ref_97) 2013; 40
Cibelli (ref_63) 2021; 69
Neely (ref_71) 2001; 98
Illes (ref_15) 2021; 268
Duan (ref_102) 2020; 162
Roemer (ref_12) 2007; 130
Nagelhus (ref_38) 1998; 18
Rossi (ref_91) 2012; 60
Tradtrantip (ref_101) 2012; 71
Frigeri (ref_37) 1998; 102
Sepramaniam (ref_79) 2012; 287
Kachinsky (ref_67) 1999; 145
Lennon (ref_2) 2004; 364
Misu (ref_13) 2007; 130
Chen (ref_29) 2020; 130
Kurosawa (ref_23) 2015; 3
Suzuki (ref_59) 2008; 1778
Yang (ref_53) 1995; 270
Ramadhanti (ref_106) 2013; 32
Crane (ref_61) 2009; 122
Duan (ref_18) 2018; 15
Sorbo (ref_51) 2008; 47
Pisani (ref_80) 2014; 25
Nicchia (ref_90) 2009; 57
Wingerchuk (ref_1) 2015; 85
Zhang (ref_10) 2011; 70
Ratelade (ref_20) 2012; 123
Koyama (ref_40) 1999; 276
Verbavatz (ref_49) 1997; 110
Strand (ref_58) 2009; 48
Duan (ref_24) 2019; 7
References_xml – volume: 137
  start-page: 467
  year: 2019
  ident: ref_11
  article-title: Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-018-1950-8
– volume: 77
  start-page: 425
  year: 2012
  ident: ref_76
  article-title: Identification of new M23A mRNA of mouse aquaporin-4 expressed in brain, liver, and kidney
  publication-title: Biochemistry
– volume: 271
  start-page: 4577
  year: 1996
  ident: ref_48
  article-title: The mercurial insensitive water channel (AQP-4) forms orthogonal arrays in stably transfected Chinese hamster ovary cells
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.271.9.4577
– ident: ref_98
  doi: 10.1371/journal.pone.0010455
– volume: 17
  start-page: 759
  year: 2021
  ident: ref_14
  article-title: Hope for patients with neuromyelitis optica spectrum disorders—From mechanisms to trials
  publication-title: Nat. Rev. Neurol.
  doi: 10.1038/s41582-021-00568-8
– volume: 110
  start-page: 2855
  year: 1997
  ident: ref_49
  article-title: Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.110.22.2855
– volume: 307
  start-page: C957
  year: 2014
  ident: ref_89
  article-title: AQP4 plasma membrane trafficking or channel gating is not significantly modulated by phosphorylation at COOH-terminal serine residues
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00182.2014
– volume: 130
  start-page: 1224
  year: 2007
  ident: ref_13
  article-title: Loss of aquaporin 4 in lesions of neuromyelitis optica: Distinction from multiple sclerosis
  publication-title: Brain
  doi: 10.1093/brain/awm047
– volume: 91
  start-page: 13052
  year: 1994
  ident: ref_31
  article-title: Molecular characterization of an aquaporin cDNA from brain: Candidate osmoreceptor and regulator of water balance
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.91.26.13052
– volume: 48
  start-page: 5785
  year: 2009
  ident: ref_58
  article-title: Roles of aquaporin-4 isoforms and amino acids in square array assembly
  publication-title: Biochemistry
  doi: 10.1021/bi802231q
– volume: 70
  start-page: 943
  year: 2011
  ident: ref_10
  article-title: Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.22551
– volume: 285
  start-page: 29223
  year: 2010
  ident: ref_87
  article-title: MicroRNA 320a functions as a novel endogenous modulator of aquaporins 1 and 4 as well as a potential therapeutic target in cerebral ischemia
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.144576
– volume: 108
  start-page: 2993
  year: 1995
  ident: ref_34
  article-title: Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.108.9.2993
– volume: 126
  start-page: 699
  year: 2013
  ident: ref_22
  article-title: Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-013-1172-z
– volume: 287
  start-page: 12006
  year: 2012
  ident: ref_79
  article-title: MicroRNA-130a represses transcriptional activity of aquaporin 4 M1 promoter
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.280701
– volume: 56
  start-page: 869
  year: 2008
  ident: ref_69
  article-title: Dystrophin-dependent and -independent AQP4 pools are expressed in the mouse brain
  publication-title: Glia
  doi: 10.1002/glia.20661
– volume: 10
  start-page: 3584
  year: 1998
  ident: ref_39
  article-title: Select types of supporting cell in the inner ear express aquaporin-4 water channel protein
  publication-title: Eur. J. Neurosci.
  doi: 10.1046/j.1460-9568.1998.00360.x
– volume: 92
  start-page: 4328
  year: 1995
  ident: ref_33
  article-title: Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.92.10.4328
– volume: 269
  start-page: F775
  year: 1995
  ident: ref_32
  article-title: Distribution of aquaporin-4 water channel expression within rat kidney
  publication-title: Am. J. Physiol.
– volume: 270
  start-page: 22907
  year: 1995
  ident: ref_53
  article-title: cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.270.39.22907
– volume: 7
  start-page: 51
  year: 2019
  ident: ref_85
  article-title: AQP4ex is crucial for the anchoring of AQP4 at the astrocyte end-feet and for neuromyelitis optica antibody binding
  publication-title: Acta Neuropathol. Commun.
  doi: 10.1186/s40478-019-0707-5
– volume: 58
  start-page: 5178
  year: 2021
  ident: ref_93
  article-title: Aquaporin-4 Removal from the Plasma Membrane of Human Müller Cells by AQP4-IgG from patients with neuromyelitis optica induces changes in cell volume homeostasis: The first step of retinal injury?
  publication-title: Mol. Neurobiol.
  doi: 10.1007/s12035-021-02491-x
– volume: 91
  start-page: 367
  year: 2008
  ident: ref_72
  article-title: New isoforms of rat Aquaporin-4
  publication-title: Genomics
  doi: 10.1016/j.ygeno.2007.12.003
– volume: 65
  start-page: 790
  year: 2017
  ident: ref_84
  article-title: Translational readthrough generates new astrocyte AQP4 isoforms that modulate supramolecular clustering, glial endfeet localization, and water transport
  publication-title: Glia
  doi: 10.1002/glia.23126
– volume: 85
  start-page: 177
  year: 2015
  ident: ref_1
  article-title: International Panel for NMO Diagnosis. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000001729
– ident: ref_86
  doi: 10.3390/ijms21041531
– volume: 287
  start-page: 13829
  year: 2012
  ident: ref_99
  article-title: Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arrays
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.344325
– volume: 147
  start-page: 645
  year: 1999
  ident: ref_66
  article-title: Different dystrophin-like complexes are expressed in neurons and glia
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.147.3.645
– volume: 48
  start-page: 335
  year: 2000
  ident: ref_75
  article-title: Identification of a new form of AQP4 mRNA that is developmentally expressed in mouse brain
  publication-title: Pediatr. Res.
  doi: 10.1203/00006450-200009000-00012
– volume: 62
  start-page: 692
  year: 2014
  ident: ref_28
  article-title: Neuromyelitis optica IgG stimulates an immunological response in rat astrocyte cultures
  publication-title: Glia
  doi: 10.1002/glia.22635
– volume: 269
  start-page: 5497
  year: 1994
  ident: ref_30
  article-title: Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(17)37486-0
– volume: 286
  start-page: 9216
  year: 2011
  ident: ref_96
  article-title: Identification of two major conformational aquaporin-4 epitopes for neuromyelitis optica autoantibody binding
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.123000
– volume: 56
  start-page: 65
  year: 2013
  ident: ref_105
  article-title: Immunological function of aquaporin-4 in stab-wounded mouse brain in concert with a pro-inflammatory cytokine inducer, osteopontin
  publication-title: Mol. Cell Neurosci.
  doi: 10.1016/j.mcn.2013.02.002
– volume: 202
  start-page: 473
  year: 2005
  ident: ref_3
  article-title: IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20050304
– volume: 268
  start-page: 4522
  year: 2021
  ident: ref_15
  article-title: Recent progress in maintenance treatment of neuromyelitis optica spectrum disorder
  publication-title: J. Neurol.
  doi: 10.1007/s00415-020-10235-5
– volume: 7
  start-page: 112
  year: 2019
  ident: ref_24
  article-title: Complement-independent bystander injury in AQP4-IgG seropositive neuromyelitis optica produced by antibody-dependent cellular cytotoxicity
  publication-title: Acta Neuropathol. Commun.
  doi: 10.1186/s40478-019-0766-7
– volume: 205
  start-page: 2473
  year: 2008
  ident: ref_25
  article-title: Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20081241
– volume: 60
  start-page: 2027
  year: 2012
  ident: ref_91
  article-title: Neuromyelitis optica IgG does not alter aquaporin-4 water permeability, plasma membrane M1/M23 isoform content, or supramolecular assembly
  publication-title: Glia
  doi: 10.1002/glia.22417
– volume: 130
  start-page: 4025
  year: 2020
  ident: ref_29
  article-title: Astrocyte-microglia interaction drives evolving neuromyelitis optica lesion
  publication-title: J. Clin. Investig.
– volume: 155
  start-page: 113
  year: 2001
  ident: ref_70
  article-title: In vivo requirement of the alpha-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200106158
– volume: 284
  start-page: 35850
  year: 2009
  ident: ref_60
  article-title: Live cell analysis of aquaporin-4 m1/m23 interactions and regulated orthogonal array assembly in glial cells
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.071670
– volume: 287
  start-page: F501
  year: 2004
  ident: ref_57
  article-title: Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells
  publication-title: Am. J. Physiol. Renal. Physiol.
  doi: 10.1152/ajprenal.00439.2003
– volume: 322
  start-page: 104
  year: 2007
  ident: ref_103
  article-title: Viral envelope protein gp64 transgenic mouse facilitates the generation of monoclonal antibodies against exogenous membrane proteins displayed on baculovirus
  publication-title: J. Immunol. Methods
  doi: 10.1016/j.jim.2007.02.005
– volume: 69
  start-page: 2221
  year: 2007
  ident: ref_4
  article-title: Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica
  publication-title: Neurology
  doi: 10.1212/01.WNL.0000289761.64862.ce
– volume: 355
  start-page: 628
  year: 2006
  ident: ref_47
  article-title: Implications of the aquaporin-4 structure on array formation and cell adhesion
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2005.10.081
– volume: 130
  start-page: 1194
  year: 2007
  ident: ref_12
  article-title: Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis
  publication-title: Brain
  doi: 10.1093/brain/awl371
– volume: 18
  start-page: 5730
  year: 2008
  ident: ref_19
  article-title: Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.181.8.5730
– volume: 286
  start-page: 16516
  year: 2011
  ident: ref_95
  article-title: Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.227298
– volume: 100
  start-page: 13609
  year: 2003
  ident: ref_56
  article-title: Aquaporin-4 square array assembly: Opposing actions of M1 and M23 isoforms
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.2235843100
– volume: 105
  start-page: 2156
  year: 2008
  ident: ref_68
  article-title: Expression of multiple AQP4 pools in the plasma membrane and their association with the dystrophin complex
  publication-title: J. Neurochem.
  doi: 10.1111/j.1471-4159.2008.05302.x
– volume: 57
  start-page: 1363
  year: 2009
  ident: ref_90
  article-title: Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies
  publication-title: Glia
  doi: 10.1002/glia.20855
– volume: 109
  start-page: 1245
  year: 2012
  ident: ref_100
  article-title: Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1109980108
– volume: 41
  start-page: 267
  year: 1997
  ident: ref_55
  article-title: Cloning and chromosomal localization of mouse aquaporin 4: Exclusion of a candidate mutant phenotype, ataxia
  publication-title: Genomics
  doi: 10.1006/geno.1997.4641
– volume: 120
  start-page: 899
  year: 2012
  ident: ref_77
  article-title: An astrocyte-specific enhancer of the aquaporin-4 gene functions through a consensus sequence of POU transcription factors in concert with multiple upstream elements
  publication-title: J. Neurochem.
  doi: 10.1111/j.1471-4159.2012.07652.x
– volume: 7
  start-page: 77
  year: 2016
  ident: ref_83
  article-title: The binding property of a monoclonal antibody against the extracellular domains of aquaporin-4 directs aquaporin-4 toward endocytosis
  publication-title: Biochem. Biophys. Rep.
– volume: 278
  start-page: C1108
  year: 2000
  ident: ref_42
  article-title: Skeletal muscle function and water permeability in aquaporin-4 deficient mice
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.2000.278.6.C1108
– volume: 273
  start-page: C1549
  year: 1997
  ident: ref_36
  article-title: Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat
  publication-title: Am. J. Physiol.
  doi: 10.1152/ajpcell.1997.273.5.C1549
– volume: 211
  start-page: 110
  year: 2009
  ident: ref_94
  article-title: Identification of binding sites for anti-aquaporin 4 antibodies in patients with neuromyelitis optica
  publication-title: J. Neuroimmunol.
  doi: 10.1016/j.jneuroim.2009.04.001
– volume: 95
  start-page: 11981
  year: 1998
  ident: ref_50
  article-title: Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.95.20.11981
– volume: 381
  start-page: 208
  year: 1996
  ident: ref_35
  article-title: A water channel closely related to rat brain aquaporin 4 is expressed in acid- and pepsinogen-secretory cells of human stomach
  publication-title: FEBS Lett.
  doi: 10.1016/0014-5793(96)00092-0
– volume: 59
  start-page: 1056
  year: 2011
  ident: ref_74
  article-title: Aquaporin-4 Mz isoform: Brain expression, supramolecular assembly and neuromyelitis optica antibody binding
  publication-title: Glia
  doi: 10.1002/glia.21177
– volume: 168
  start-page: 903
  year: 2010
  ident: ref_52
  article-title: Higher order structure of aquaporin-4
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2010.02.008
– volume: 98
  start-page: 14108
  year: 2001
  ident: ref_71
  article-title: Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.241508198
– volume: 33
  start-page: 382
  year: 1996
  ident: ref_73
  article-title: Gene structure, cDNA cloning, and expression of a mouse mercurial-insensitive water channel
  publication-title: Genomics
  doi: 10.1006/geno.1996.0214
– volume: 377
  start-page: 463
  year: 2008
  ident: ref_88
  article-title: Phosphorylation in the C-terminal domain of Aquaporin-4 is required for Golgi transition in primary cultured astrocytes
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2008.09.155
– volume: 25
  start-page: 470
  year: 2014
  ident: ref_80
  article-title: A novel human aquaporin-4 splice variant exhibits a dominant-negative activity: A new mechanism to regulate water permeability
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e13-06-0331
– volume: 215
  start-page: 31
  year: 2009
  ident: ref_8
  article-title: Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: An in vitro study
  publication-title: J. Neuroimmunol.
  doi: 10.1016/j.jneuroim.2009.07.014
– volume: 122
  start-page: 813
  year: 2009
  ident: ref_61
  article-title: Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.042341
– volume: 364
  start-page: 2106
  year: 2004
  ident: ref_2
  article-title: A serum autoantibody marker of neuromyelitis optica: Distinction from multiple sclerosis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(04)17551-X
– volume: 123
  start-page: 2306
  year: 2013
  ident: ref_21
  article-title: Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI67554
– volume: 276
  start-page: C621
  year: 1999
  ident: ref_40
  article-title: Expression and localization of aquaporins in rat gastrointestinal tract
  publication-title: Am. J. Physiol.
  doi: 10.1152/ajpcell.1999.276.3.C621
– volume: 133
  start-page: 349
  year: 2010
  ident: ref_9
  article-title: Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice
  publication-title: Brain
  doi: 10.1093/brain/awp309
– volume: 133
  start-page: 2578
  year: 2010
  ident: ref_26
  article-title: Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury
  publication-title: Brain
  doi: 10.1093/brain/awq177
– volume: 18
  start-page: 208
  year: 2021
  ident: ref_16
  article-title: Neuromyelitis optica spectrum disorders: From pathophysiology to therapeutic strategies
  publication-title: J. Neuroinflammation
  doi: 10.1186/s12974-021-02249-1
– volume: 47
  start-page: 2631
  year: 2008
  ident: ref_51
  article-title: The molecular composition of square arrays
  publication-title: Biochemistry
  doi: 10.1021/bi702146k
– volume: 3
  start-page: 82
  year: 2015
  ident: ref_23
  article-title: Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody
  publication-title: Acta Neuropathol. Commun.
  doi: 10.1186/s40478-015-0259-2
– volume: 93
  start-page: 10908
  year: 1996
  ident: ref_54
  article-title: The human AQP4 gene: Definition of the locus encoding two water channel polypeptides in brain
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.93.20.10908
– volume: 38
  start-page: 11156
  year: 1999
  ident: ref_46
  article-title: Heterotetrameric composition of aquaporin-4 water channels
  publication-title: Biochemistry
  doi: 10.1021/bi990941s
– volume: 66
  start-page: 630
  year: 2009
  ident: ref_5
  article-title: Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.21837
– volume: 1778
  start-page: 1181
  year: 2008
  ident: ref_59
  article-title: Formation of aquaporin-4 arrays is inhibited by palmitoylation of N-terminal cysteine residues
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamem.2007.12.007
– volume: 66
  start-page: 617
  year: 2009
  ident: ref_6
  article-title: Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.21802
– volume: 59
  start-page: 1923
  year: 2011
  ident: ref_82
  article-title: Translational regulation mechanisms of aquaporin-4 supramolecular organization in astrocytes
  publication-title: Glia
  doi: 10.1002/glia.21234
– volume: 285
  start-page: 4562
  year: 2010
  ident: ref_81
  article-title: Evidences for a leaky scanning mechanism for the synthesis of the shorter M23 protein isoform of aquaporin-4: Implication in orthogonal array formation and neuromyelitis optica antibody interaction
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.069245
– volume: 114
  start-page: 5491
  year: 2017
  ident: ref_27
  article-title: Autoantibody-induced internalization of CNS AQP4 water channel and EAAT2 glutamate transporter requires astrocytic Fc receptor
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1701960114
– volume: 18
  start-page: 2506
  year: 1998
  ident: ref_38
  article-title: Aquaporin-4 water channel protein in the rat retina and optic nerve: Polarized expression in Müller cells and fibrous astrocytes
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.18-07-02506.1998
– volume: 173
  start-page: 103
  year: 2016
  ident: ref_104
  article-title: High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with the neuromyelitis optica autoantibody, NMO-IgG
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/bph.13340
– volume: 451
  start-page: 562
  year: 2014
  ident: ref_43
  article-title: Expression and localization of aquaporin-4 in sensory ganglia
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2014.08.026
– volume: 102
  start-page: 695
  year: 1998
  ident: ref_37
  article-title: Expression of aquaporin-4 in fast-twitch fibers of mammalian skeletal muscle
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI2545
– volume: 71
  start-page: 314
  year: 2012
  ident: ref_101
  article-title: Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.22657
– volume: 13
  start-page: 43
  year: 2012
  ident: ref_62
  article-title: Post-Golgi supramolecular assembly of aquaporin-4 in orthogonal arrays
  publication-title: Traffic
  doi: 10.1111/j.1600-0854.2011.01299.x
– volume: 32
  start-page: 270
  year: 2013
  ident: ref_106
  article-title: A novel monoclonal antibody against the C-terminal region of aquaporin-4
  publication-title: Monoclon. Antib. Immunodiagn. Immunother.
  doi: 10.1089/mab.2013.0007
– volume: 102
  start-page: 1025
  year: 2021
  ident: ref_45
  article-title: Fluid Transport in the Brain
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00031.2020
– volume: 459
  start-page: 305
  year: 1999
  ident: ref_41
  article-title: High-resolution immunogold cytochemistry indicates that AQP4 is concentrated along the basal membrane of parietal cell in rat stomach
  publication-title: FEBS Lett.
  doi: 10.1016/S0014-5793(99)01256-9
– volume: 17
  start-page: 171
  year: 1997
  ident: ref_44
  article-title: Specialized membrane domains for water transport in glial cells: High-resolution immunogold cytochemistry of aquaporin-4 in rat brain
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.17-01-00171.1997
– volume: 15
  start-page: 294
  year: 2018
  ident: ref_18
  article-title: Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica
  publication-title: J. Neuroinflamm.
  doi: 10.1186/s12974-018-1333-z
– volume: 8
  start-page: 2739
  year: 1997
  ident: ref_65
  article-title: Dystroglycan in the cerebellum is a laminin alpha 2-chain binding protein at the glial-vascular interface and is expressed in Purkinje cells
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/j.1460-9568.1996.tb01568.x
– volume: 69
  start-page: 2235
  year: 2021
  ident: ref_64
  article-title: Regulation of aquaporin-4 expression in the central nervous system investigated using M23-AQP4 null mouse
  publication-title: Glia
  doi: 10.1002/glia.24032
– volume: 591
  start-page: 3906
  year: 2017
  ident: ref_78
  article-title: The dual effects of the astrocyte-specific enhancer of the AQP4 M1 promoter
  publication-title: FEBS Lett.
  doi: 10.1002/1873-3468.12910
– volume: 260
  start-page: 107
  year: 2013
  ident: ref_92
  article-title: Establishment of monoclonal antibodies against the extracellular domain that block binding of NMO-IgG to AQP4
  publication-title: J. Neuroimmunol.
  doi: 10.1016/j.jneuroim.2013.03.003
– volume: 162
  start-page: 107827
  year: 2020
  ident: ref_102
  article-title: Affinity-matured ‘aquaporumab’ anti-aquaporin-4 antibody for therapy of seropositive neuromyelitis optica spectrum disorders
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2019.107827
– volume: 134
  start-page: 35
  year: 2017
  ident: ref_17
  article-title: Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-017-1734-6
– volume: 145
  start-page: 391
  year: 1999
  ident: ref_67
  article-title: A PDZ-containing scaffold related to the dystrophin complex at the basolateral membrane of epithelial cells
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.145.2.391
– volume: 19
  start-page: 3369
  year: 2008
  ident: ref_107
  article-title: Aquaporin-4 dynamics in orthogonal arrays in live cells visualized by quantum dot single particle tracking
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e08-03-0322
– volume: 69
  start-page: 473
  year: 2021
  ident: ref_63
  article-title: Orthogonal arrays of particle assembly are essential for normal aquaporin-4 expression level in the brain
  publication-title: Glia
  doi: 10.1002/glia.23909
– volume: 386
  start-page: 623
  year: 2009
  ident: ref_7
  article-title: Neuromyelitis optica: Passive transfer to rats by human immunoglobulin
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2009.06.085
– volume: 40
  start-page: 21
  year: 2013
  ident: ref_97
  article-title: Astrocytic autoantibody of neuromyelitis optica (NMO-IgG) binds to aquaporin-4 extracellular loops, monomers, tetramers and high order arrays
  publication-title: J. Autoimmun.
  doi: 10.1016/j.jaut.2012.07.008
– volume: 123
  start-page: 861
  year: 2012
  ident: ref_20
  article-title: Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-012-0986-4
SSID ssj0000800823
Score 2.32361
SecondaryResourceType review_article
Snippet Since the discovery of a specific autoantibody in patients with neuromyelitis optica spectrum disorder (NMOSD) in 2004, the water channel aquaporin-4 (AQP4)...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 591
SubjectTerms Amino acids
Aquaporin 4
Aquaporin 4 - metabolism
aquaporin-4 (AQP4)
Aquaporins
Astrocytes
Autoantibodies
Autoimmune diseases
Autoimmunity
Central nervous system
Central Nervous System - metabolism
Complement System Proteins - metabolism
Cytotoxicity
Demyelinating diseases
Demyelination
Endocytosis
Humans
Immunoglobulin G
Localization
Multiple sclerosis
Musculoskeletal system
Nervous system
Neuromyelitis
Neuromyelitis Optica - metabolism
Neuromyelitis Optica - pathology
neuromyelitis optica spectrum disorders (NMOSD)
NMO-IgG
Orthogonal arrays of particles (OAPs)
Pathogenesis
Peptides
Review
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1NT9wwELUQJy6oLdCmBeRKhUsVETve2OGWIhDiUC4gcYv8MVG36mYXNltp_31nnOxqt2rVSy85xBPL8YztN_b4DWOfEBE76aBMC5WZVDl8mBJ8aqUNwmPTpYtsn1-L20d19zR62kj1RTFhPT1w33EXTcita0yprQ_Kg7ChBAU2Aw-auOBo9sU1b8OZ-j7gICPzPtI9R7_-gm6zC4kmOyrF1hoUqfr_hC9_D5PcWHduXrH9ATDyqm_oa7YD7Rt2ULXoLE-W_JzHEM64N37A2up5YWcUUpcqPm55ZN6YLIFC3Ob8fkb71pwyzncviwlfEW_OL3nFH2JEOJ82vFp003G8NdItqRJEiHzYA8YKX35OF3Pe85wfsseb64er23RIqJB6pVWXjuiM1NtsBMZLnenCZiH3xmfooykw1pjC6NAgCCkIB8gQhM2ll84EoRxijSO2205beMc4aNAOrM6VDUoE9Ltk2eAHPpR0VVck7POqi2s_sI1T0osfNXodpJB6UyEJO1tLz3qWjb_IfSFtrWWIGzu-QIupB4up_2UxCTte6boeBuy8lgWdeBYISBP2cV2MQ43OT2wL2LckQ6s3Is6Eve1NY92SHJGoEiZLmN4ymq2mbpe042-RzrukOdeI9__j3z6wPUn3M4iMUh-zXTQnOEHU1LnTOEB-AUkfGoA
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Nb9QwEB1V5cIFAeUjUJCRgAsKxI43dpAQCoiqQgIuXam3yLEduqibbHezVfffM-Mkqy4ULjkkY8vyjOM39swbgJeIiCtR-TzOZKJjWeFD597GRhjHLQ5dVIHt83t2PJVfTyenezBWGx0mcHWja0f1pKbL87dXF5uPuOA_kMeJLvs7SlTnAq1xQmnst3BPUrREvw1A_9eAi7RI-8j3vxrt7EmBuv8mvPln2OS1fejoLtwZACQreo3fgz3f3IeDokHneb5hr1kI6Qxn5QfQFBdrs6AQu1iyWcMCE8d84ynkbcV-LOgcm1EF-m65nrORiHP1nhXsJESIs7ZmxbprZyGLpNtQJ4gY2XAmjB0uL9v1ivW85w9gevTl5PNxPBRYiK1UsosndGdqTTLx2gqVqMwkLrXaJuizSa-N1plWrkZQkhEuEM5xkworKu24rBB7PIT9pm38Y2BeeVV5o1JpnOQO_TCR19jAupxSd3kEb8YpLu3APk5FMM5L9EJIIeV1hUTwaiu96Fk3_iH3ibS1lSGu7PCiXf4sh6VX1i41Va1zZayT1nPjci-9Sbz1itgEIzgcdV2O9leKjG5AMwSoEbzYfsalR_cppvE4tyRDuzki0Age9aaxHUmKyFRynUSgdoxmZ6i7X5rZWaD3zukfrPmT_w_rKdwWlIlBtJPqEPbRUPwzxEdd9TyY_m8kMxJH
  priority: 102
  providerName: Scholars Portal
Title Aquaporin-4 in Neuromyelitis Optica Spectrum Disorders: A Target of Autoimmunity in the Central Nervous System
URI https://www.ncbi.nlm.nih.gov/pubmed/35454180
https://www.proquest.com/docview/2652956083
https://www.proquest.com/docview/2654299561
https://pubmed.ncbi.nlm.nih.gov/PMC9030581
https://doaj.org/article/fd3abf897acd4ce1ad9e4ea0ece70328
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Nb9QwELWgvXBBQPkILSsjARcUNXa8scMFpahVhURBqJX2Fjm2U1Zik-0mW2n_PTOON3QRcPEhdizLM7bfjMdvCHkDiLjilcvjTCQqFhUUKncm1lxbZmDovPJsnxfZ-ZX4PJvOgsOtC2GV2z3Rb9S2NegjP-YZXkllgBg-Lm9izBqFt6shhcZ9so_UZRjSJWdy9LEgGlI8HeLdU7Duj_FNO-OguNOc7ZxEnrD_byjzz2DJO6fP2SPyMMBGWgxyfkzuueYJOSgaMJkXG_qO-kBO7yE_IE1xs9ZLDKyLBZ031PNvLDYOA906-nWJ3muKeef71XpBt_Sb3Qda0EsfF07bmhbrvp37tyP9BjsBnEiDJxg6XN22644ObOdPydXZ6eWn8zikVYiNkKKPp3hTanQydcpwmchMJzY1yiRgqQmntFKZkrYGKJIhGuDWMp1ywytlmagAcTwje03buBeEOulk5bRMhbaCWbC-eF7DD8bm-GCXReT9dopLEzjHMfXFzxJsDxRIeVcgEXk7tl4OXBv_aHeC0hrbIEO2_9Cursuw4MraprqqVS61scI4pm3uhNOJM04ih2BEjrayLsOy7crfShaR12M1LDi8RdGNg7nFNniGA-6MyPNBNcaRpIBHBVNJROSO0uwMdbemmf_wpN457ryKvfz_sA7JA47vL5BsUh6RPVAU9wpQUV9NvOpPyP7J6cW37xPvW4Dyi1C_AOvqEx4
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-N7gFeEDA-MgYYifGCoiWOmzhICGWwqWOjINRJe8sc24FKa9K1Kaj_FH8jd_koKwLe9pKHxLEs353vd-f7AHiBiDjjmY3dUHjSFRk-ZGy1q7gyvsal86yu9jkMB6fiw1n_bAN-drkwFFbZnYn1QW1KTT7yPR7SlVSIiOHt9NKlrlF0u9q10GjY4tguf6DJNn9z9B7pu8v54cHo3cBtuwq4WkSicvt0UaiV17dS8wjNeOWZQEvtoaEirFRShjIyOWrikJQhN8ZXAdc8k8YXGSpcnPcGbIoATZkebO4fDD9_WXl1CH9JHjQR9kEQe3uURe9zFJV-7K_pvrpFwN9w7Z_hmVf03eEduN0CVZY0nHUXNmxxD7aSAo30yZK9ZHXoaO2T34IiuVyoKYXyuYKNC1ZX_JgsLYXWzdmnKfnLGXW6r2aLCesKfs5fs4SN6kh0VuYsWVTluM5WqZY0CSJT1vqeccLZ93IxZ0199ftwei1b_gB6RVnYR8BsZKPMqigQygjfoL3H4xx_0CamFGHfgVfdFqe6rXJOzTYuUrR2iCDpVYI4sLsaPW2qe_xj3D5RazWGanLXL8rZ17QV8TQ3gcpyGUdKG6Gtr0xshVWe1TaiqoUO7HS0TtuDYp7-ZmsHnq8-o4jTvY0qLO4tjSHUgEjXgYcNa6xWEiACFr70HIjWmGZtqetfivG3uox4TGe99Lf_v6xncHMw-niSnhwNjx_DLU7ZH1TqMtqBHjKNfYKYrMqetoLA4Py6Ze8XiT5L9A
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKkRAXBJRHSgEjUS4o2tjxxg4SQoGyaikqHFppb8GxHVipm2z3Adq_xq9jxnnQRcCtlxwSx7I8M56HZ74h5DlYxAUvXBomIlKhKOChUmdCzbVlBpbOC4_2eZIcnokP4-F4i_zsamEwrbI7E_1BbWuDMfIBT_BKKgGLYVC2aRGfD0ZvZhchdpDCm9aunUbDIsdu_QPct8XrowOg9T7no_en7w7DtsNAaIQUy3CIl4ZGR0OnDJfg0uvIxkaZCJwW4ZRWKlHSlqCVE1SM3FqmY254oSwTBShfmPcauS7jIUMZk2PZx3fQElM8bnLt4ziNBlhPzzgIzTBlG1rQNwv4m4X7Z6LmJc03uk1utSYrzRoeu0O2XHWX7GQVuOvTNX1BfRKpj87vkCq7WOkZJvWFgk4q6rE_pmuHSXYL-mmGkXOKPe-X89WUdtCfi1c0o6c-J53WJc1Wy3ri61aWa5wEbFTaRqFhwvn3erWgDdL6PXJ2JRt-n2xXdeUeEuqkk4XTMhbaCmbB8-NpCT8Ym2KxMAvIy26Lc9PinWPbjfMc_B4kSH6ZIAHZ70fPGpyPf4x7i9TqxyA6t39Rz7_mrbDnpY11UapUamOFcUzb1AmnI2ecRPzCgOx1tM7bI2OR_2bwgDzrP4Ow4w2OrhzsLY5B-wFs3oA8aFijX0kMtrBgKgqI3GCajaVufqkm3zygeIqnvmK7_1_WU3IDJC7_eHRy_Ijc5FgGgpiXco9sA8-4x2CcLYsnXgoo-XLVYvcLNDVOxA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Aquaporin-4+in+Neuromyelitis+Optica+Spectrum+Disorders%3A+A+Target+of+Autoimmunity+in+the+Central+Nervous+System&rft.jtitle=Biomolecules+%28Basel%2C+Switzerland%29&rft.au=Abe%2C+Yoichiro&rft.au=Yasui%2C+Masato&rft.date=2022-04-17&rft.pub=MDPI+AG&rft.eissn=2218-273X&rft.volume=12&rft.issue=4&rft.spage=591&rft_id=info:doi/10.3390%2Fbiom12040591&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2218-273X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2218-273X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2218-273X&client=summon