Postischemic regulation of central histamine receptors

• Published in: Neuroscience Vol. 136; no. 1; pp. 371 - 379
• Main Authors: Lozada, A., Munyao, N., Sallmen, T., Lintunen, M., Leurs, R., Lindsberg, P.J., Panula, P.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 2005; Elsevier
• Subjects: Animals; Autoradiography; Biological and medical sciences; Blotting, Western; Brain - metabolism; Brain Ischemia - metabolism; hippocampus; histamine H 1 receptor; histamine H 2 receptor; histamine H 3 receptor; In Situ Hybridization; Male; Medical sciences; Neurology; Rats; Rats, Wistar; Receptors, Histamine H1 - genetics; Receptors, Histamine H1 - metabolism; Receptors, Histamine H2 - metabolism; Receptors, Histamine H3 - metabolism; Reperfusion Injury - metabolism; striatum; thalamus; Vascular diseases and vascular malformations of the nervous system; histamine H 2 receptor; CA1; striatum; hippocampus; histamine H 3 receptor; histamine H 1 receptor; CBF; MAO B; MAO; thalamus; LDF; Rat; Central nervous system; Cardiovascular disease; Encephalon; Vascular disease; Reperfusion; histamine H1 receptor; Thalamus; Cerebrovascular disease; histamine H3 receptor; Nervous system diseases; H3 histamine receptor; Rodentia; Basal ganglion; Corpus striatum; Cerebral disorder; Vertebrata; Mammalia; Animal; Central nervous system disease; Brain ischemia; H1 Histamine receptor; Hippocampus; H2 Histamine receptor; histamine H2 receptor

This study characterizes changes occurring in the central histaminergic system associated with ischemia–reperfusion pathology in the rat. Specifically, after a postocclusion time period of 48 h, we have analyzed histamine H 1 receptor mRNA expression, histamine H 2 receptor protein amount and bindin...