Loss of α-1,2-mannosidase MAN1C1 promotes tumorigenesis of intrahepatic cholangiocarcinoma through enhancing CD133-FIP200 interaction

• Published in: Cell reports (Cambridge) Vol. 42; no. 12; p. 113588
• Main Authors: Wei, Yuanyan, Chen, Qihang, Chen, Jiayue, Zhou, Chenhao, Geng, Shuting, Shi, Danfang, Huang, Sijing, Liang, Zhiwei, Chen, Xiaoning, Ren, Ning, Jiang, Jianhai
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.12.2023; Elsevier
• Subjects: CD133; CP: Cancer; high mannose glycan; intrahepatic cholangiocarcinoma; N-glycan; tumor-initiating cell; α-1,2-mannosylation; CP: Cancer; α-1,2-mannosylation; high mannose glycan; tumor-initiating cell; N-glycan; intrahepatic cholangiocarcinoma; CD133

CD133 is widely used as a marker to isolate tumor-initiating cells in many types of cancers. The structure of N-glycan on CD133 is altered during the differentiation of tumor-initiating cells. However, the relationship between CD133 N-glycosylation and stem cell characteristics remains elusive. Here...