A Tri-fusion Reporter Mouse Reveals Tissue-Specific FGF1B Promoter Activity in vivo

• Published in: Scientific reports Vol. 9; no. 1; pp. 11143 - 13
• Main Authors: Liu, Shan-Wen, Hsu, Ching-Han, Chen, Mei-Ru, Chiu, Ing-Ming, Lin, Kurt M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.07.2019; Nature Publishing Group
• Subjects: 13/106; 13/51; 14; 14/5; 38; 59; 59/78; 631/136/2434/1822; 631/1647/2017/1958; 631/1647/245/2160; 631/1647/245/2222; 64/110; 96/44; Animals; Brain stem; Busulfan; Cell fusion; Cell proliferation; Cell Proliferation - genetics; CHO Cells; Cricetulus; Fibroblast growth factor 1; Fibroblast Growth Factor 1 - genetics; Genes, Reporter - genetics; Green fluorescent protein; Green Fluorescent Proteins - genetics; Herpes simplex; Humanities and Social Sciences; Kinases; Leydig cells; Leydig Cells - physiology; Luciferases, Firefly - genetics; Luminescent Proteins - genetics; Male; Mice; Mice, Transgenic; multidisciplinary; Nasopharynx; Neural stem cells; Neuroimaging; Promoter Regions, Genetic - genetics; Reporter gene; Reproductive system; Science; Science (multidisciplinary); Spermatogenesis; Spermatogenesis - genetics; Spine; Stem cell transplantation; Stem cells; Thymidine; Thymidine kinase; Thymidine Kinase - genetics; Toxicity; Transgenic mice

Transgenic mice harboring imaging reporters take full advantage of imaging technologies in studies using living mice. Here, we established a tri-fusion multimodal reporter gene containing fragments from firefly luciferase, enhanced green fluorescent protein, and herpes simplex virus type 1 thymidine...