Heterogeneous Nuclear Ribonucleoprotein F Mediates Insulin Inhibition of Bcl2-Modifying Factor Expression and Tubulopathy in Diabetic Kidney

We investigated the molecular mechanism(s) by which insulin prevents Bcl2-modifying factor (Bmf)-induced renal proximal tubular cell (RPTC) apoptosis and loss in diabetic mice. Transgenic mice (Tg) mice specifically overexpressing human BMF in RPTCs and non-Tg littermates were studied at 10 to 20 we...

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Published inScientific reports Vol. 9; no. 1; p. 6687
Main Authors Ghosh, Anindya, Zhao, Shuiling, Lo, Chao-Sheng, Maachi, Hasna, Chenier, Isabelle, Lateef, Muhammad Abdul, Abdo, Shaaban, Filep, Janos G., Ingelfinger, Julie R., Zhang, Shao-Ling, Chan, John S. D.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 30.04.2019
Nature Publishing Group
Subjects
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38/44
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Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - metabolism
Animals
Apoptosis
Apoptosis - drug effects
Apoptosis - genetics
Biomarkers
Blood pressure
Blood Pressure - genetics
Creatinine
Diabetes
Diabetes mellitus
Diabetic Nephropathies - etiology
Diabetic Nephropathies - metabolism
Diabetic Nephropathies - pathology
Disease Models, Animal
Gene Expression Regulation - drug effects
Genetic Loci
Glucose - metabolism
Heterogeneous-Nuclear Ribonucleoprotein Group F-H - metabolism
Humanities and Social Sciences
Humans
Immunohistochemistry
Insulin
Insulin - metabolism
Insulin - pharmacology
Kidney Tubules, Proximal - metabolism
Kidney Tubules, Proximal - pathology
Kidneys
Kinases
MAP kinase
Mice
Mice, Transgenic
multidisciplinary
Protein kinase
Regulatory sequences
Science
Science (multidisciplinary)
siRNA
Transcription
Transfection
Transgenic mice
Online AccessGet full text

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Abstract We investigated the molecular mechanism(s) by which insulin prevents Bcl2-modifying factor (Bmf)-induced renal proximal tubular cell (RPTC) apoptosis and loss in diabetic mice. Transgenic mice (Tg) mice specifically overexpressing human BMF in RPTCs and non-Tg littermates were studied at 10 to 20 weeks of age. Non-diabetic littermates, diabetic Akita mice +/− insulin implant, Akita Tg mice specifically overexpressing heterogeneous nuclear ribonucleoprotein F (hnRNP F) in their RPTCs and immortalized rat renal proximal tubular cells (IRPTCs) were also studied. BMF -Tg mice exhibited higher systolic blood pressure, urinary albumin/creatinine ratio, RPTC apoptosis and urinary RPTCs than non-Tg mice. Insulin treatment in Akita mice and Akita mice overexpressing hnRNP F suppressed Bmf expression and RPTC apoptosis. In hyperinsulinemic-euglycemic wild type mice, renal Bmf expression was down-regulated with up-regulation of hnRNP F . In vitro , insulin inhibited high glucose-stimulation of Bmf expression, predominantly via p44/42 mitogen-activated protein kinase (MAPK) signaling. Transfection of p44/42 MAPK or hnRNP F small interfering RNA (siRNA) prevented insulin inhibition of Bmf expression. HnRNP F inhibited Bmf transcription via hnRNP F-responsive element in the Bmf promoter. Our results demonstrate that hnRNP F suppression of Bmf transcription is an important mechanism by which insulin protects RPTCs from apoptosis in diabetes.
AbstractList We investigated the molecular mechanism(s) by which insulin prevents Bcl2-modifying factor (Bmf)-induced renal proximal tubular cell (RPTC) apoptosis and loss in diabetic mice. Transgenic mice (Tg) mice specifically overexpressing human BMF in RPTCs and non-Tg littermates were studied at 10 to 20 weeks of age. Non-diabetic littermates, diabetic Akita mice +/- insulin implant, Akita Tg mice specifically overexpressing heterogeneous nuclear ribonucleoprotein F (hnRNP F) in their RPTCs and immortalized rat renal proximal tubular cells (IRPTCs) were also studied. BMF-Tg mice exhibited higher systolic blood pressure, urinary albumin/creatinine ratio, RPTC apoptosis and urinary RPTCs than non-Tg mice. Insulin treatment in Akita mice and Akita mice overexpressing hnRNP F suppressed Bmf expression and RPTC apoptosis. In hyperinsulinemic-euglycemic wild type mice, renal Bmf expression was down-regulated with up-regulation of hnRNP F. In vitro, insulin inhibited high glucose-stimulation of Bmf expression, predominantly via p44/42 mitogen-activated protein kinase (MAPK) signaling. Transfection of p44/42 MAPK or hnRNP F small interfering RNA (siRNA) prevented insulin inhibition of Bmf expression. HnRNP F inhibited Bmf transcription via hnRNP F-responsive element in the Bmf promoter. Our results demonstrate that hnRNP F suppression of Bmf transcription is an important mechanism by which insulin protects RPTCs from apoptosis in diabetes.
We investigated the molecular mechanism(s) by which insulin prevents Bcl2-modifying factor (Bmf)-induced renal proximal tubular cell (RPTC) apoptosis and loss in diabetic mice. Transgenic mice (Tg) mice specifically overexpressing human BMF in RPTCs and non-Tg littermates were studied at 10 to 20 weeks of age. Non-diabetic littermates, diabetic Akita mice +/− insulin implant, Akita Tg mice specifically overexpressing heterogeneous nuclear ribonucleoprotein F (hnRNP F) in their RPTCs and immortalized rat renal proximal tubular cells (IRPTCs) were also studied. BMF -Tg mice exhibited higher systolic blood pressure, urinary albumin/creatinine ratio, RPTC apoptosis and urinary RPTCs than non-Tg mice. Insulin treatment in Akita mice and Akita mice overexpressing hnRNP F suppressed Bmf expression and RPTC apoptosis. In hyperinsulinemic-euglycemic wild type mice, renal Bmf expression was down-regulated with up-regulation of hnRNP F . In vitro , insulin inhibited high glucose-stimulation of Bmf expression, predominantly via p44/42 mitogen-activated protein kinase (MAPK) signaling. Transfection of p44/42 MAPK or hnRNP F small interfering RNA (siRNA) prevented insulin inhibition of Bmf expression. HnRNP F inhibited Bmf transcription via hnRNP F-responsive element in the Bmf promoter. Our results demonstrate that hnRNP F suppression of Bmf transcription is an important mechanism by which insulin protects RPTCs from apoptosis in diabetes.
We investigated the molecular mechanism(s) by which insulin prevents Bcl2-modifying factor (Bmf)-induced renal proximal tubular cell (RPTC) apoptosis and loss in diabetic mice. Transgenic mice (Tg) mice specifically overexpressing human BMF in RPTCs and non-Tg littermates were studied at 10 to 20 weeks of age. Non-diabetic littermates, diabetic Akita mice +/− insulin implant, Akita Tg mice specifically overexpressing heterogeneous nuclear ribonucleoprotein F (hnRNP F) in their RPTCs and immortalized rat renal proximal tubular cells (IRPTCs) were also studied. BMF-Tg mice exhibited higher systolic blood pressure, urinary albumin/creatinine ratio, RPTC apoptosis and urinary RPTCs than non-Tg mice. Insulin treatment in Akita mice and Akita mice overexpressing hnRNP F suppressed Bmf expression and RPTC apoptosis. In hyperinsulinemic-euglycemic wild type mice, renal Bmf expression was down-regulated with up-regulation of hnRNP F. In vitro, insulin inhibited high glucose-stimulation of Bmf expression, predominantly via p44/42 mitogen-activated protein kinase (MAPK) signaling. Transfection of p44/42 MAPK or hnRNP F small interfering RNA (siRNA) prevented insulin inhibition of Bmf expression. HnRNP F inhibited Bmf transcription via hnRNP F-responsive element in the Bmf promoter. Our results demonstrate that hnRNP F suppression of Bmf transcription is an important mechanism by which insulin protects RPTCs from apoptosis in diabetes.
Abstract We investigated the molecular mechanism(s) by which insulin prevents Bcl2-modifying factor (Bmf)-induced renal proximal tubular cell (RPTC) apoptosis and loss in diabetic mice. Transgenic mice (Tg) mice specifically overexpressing human BMF in RPTCs and non-Tg littermates were studied at 10 to 20 weeks of age. Non-diabetic littermates, diabetic Akita mice +/− insulin implant, Akita Tg mice specifically overexpressing heterogeneous nuclear ribonucleoprotein F (hnRNP F) in their RPTCs and immortalized rat renal proximal tubular cells (IRPTCs) were also studied. BMF -Tg mice exhibited higher systolic blood pressure, urinary albumin/creatinine ratio, RPTC apoptosis and urinary RPTCs than non-Tg mice. Insulin treatment in Akita mice and Akita mice overexpressing hnRNP F suppressed Bmf expression and RPTC apoptosis. In hyperinsulinemic-euglycemic wild type mice, renal Bmf expression was down-regulated with up-regulation of hnRNP F . In vitro , insulin inhibited high glucose-stimulation of Bmf expression, predominantly via p44/42 mitogen-activated protein kinase (MAPK) signaling. Transfection of p44/42 MAPK or hnRNP F small interfering RNA (siRNA) prevented insulin inhibition of Bmf expression. HnRNP F inhibited Bmf transcription via hnRNP F-responsive element in the Bmf promoter. Our results demonstrate that hnRNP F suppression of Bmf transcription is an important mechanism by which insulin protects RPTCs from apoptosis in diabetes.
ArticleNumber 6687
Author Maachi, Hasna
Abdo, Shaaban
Chan, John S. D.
Zhang, Shao-Ling
Ghosh, Anindya
Lo, Chao-Sheng
Lateef, Muhammad Abdul
Zhao, Shuiling
Filep, Janos G.
Chenier, Isabelle
Ingelfinger, Julie R.
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Cites_doi 10.1210/en.2003-0220
10.1111/j.1365-2818.1988.tb04609.x
10.1152/ajprenal.00137.2002
10.1111/j.1523-1755.2005.00058.x
10.1001/archinternmed.2008.2
10.1210/en.2016-1576
10.1126/science.1062257
10.1038/cddiscovery.2015.41
10.2337/db13-1830
10.1007/s00467-015-3169-4
10.1016/S0046-8177(70)80061-2
10.1210/endo.143.8.8931
10.1152/ajpendo.00607.2007
10.1080/13813450701669084
10.1152/ajprenal.2001.280.1.F54
10.1681/ASN.2007010074
10.1159/000076749
10.1152/ajprenal.00340.2011
10.1093/ndt/15.suppl_6.74
10.1681/ASN.2004080715
10.1038/sj/cdd/4400998
10.1210/endo.142.6.8214
10.1681/asn.2005121342
10.1007/s00125-013-2910-4
10.1084/jem.20071658
10.1038/ki.2012.20
10.2337/db07-0013
10.1038/sj.leu.2403183
10.1007/s00125-015-3700-y
10.1093/ckj/sfx133
10.1038/sj.ki.5000210
10.2337/diab.46.5.887
10.1046/j.1523-1755.1999.00721.x
10.2337/db11-1349
10.1056/NEJM199309303291401
10.2337/db11-0141
10.2337/diabetes.51.5.1580
10.1096/fj.02-0130fje
10.1023/B:MCBI.0000021346.03260.7e
10.1002/path.1087
10.1038/sj.ki.5002188
10.1074/jbc.M601945200
10.1042/bj20031251
10.1038/ki.1994.290
10.1186/s12860-015-0058-4
10.1172/jci4431
10.1097/01.ASN.0000057854.32413.81
10.2337/db16-1588
10.1371/journal.pone.0051266
10.2337/db16-0796
10.1128/mcb.01155-09
10.1016/S0092-8674(00)81874-7
10.1681/ASN.V1271391
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References Mishra, Emancipator, Kern, Simonson (CR15) 2005; 67
Puthalakath, Strasser (CR32) 2002; 9
Sachetelli (CR49) 2006; 69
Korsheninnikova (CR46) 2007; 113
Nagata (CR10) 1997; 88
Labi (CR37) 2008; 205
Najafian, Kim, Crosson, Mauer (CR8) 2003; 14
Legouis (CR34) 2015; 16
Yoshioka, Kayo, Ikeda, Koizumi (CR44) 1997; 46
Chen (CR25) 2001; 142
Puthalakath (CR33) 2001; 293
Najafian, Crosson, Kim, Mauer (CR9) 2006; 17
Gundersen (CR54) 1988; 151
Wang (CR48) 2012; 7
Hsieh (CR16) 2003; 144
Wei (CR27) 2006; 281
Lo (CR47) 2015; 58
Ghosh (CR31) 2017; 158
Lo (CR29) 2017; 66
Pfeiffer, Halang, Düssmann, Byrne, Prehn (CR39) 2015; 1
Schelling (CR42) 2016; 31
Brezniceanu (CR20) 2007; 71
Brezniceanu (CR21) 2008; 57
de Boer (CR24) 2008; 168
Kumar, Zimpelmann, Robertson, Burns (CR13) 2004; 96
Afsar (CR41) 2018; 11
Wei, Guo, Zhang, Ingelfinger, Chan (CR26) 2005; 16
Gilbert, Cooper (CR3) 1999; 56
Lau (CR22) 2012; 61
Lo (CR28) 2012; 61
Grgic (CR40) 2012; 82
Wang (CR43) 1999; 103
Véniant, Heudes, Clozel, Bruneval, Ménard (CR52) 1994; 46
Tang (CR55) 1995; 268
Liu (CR18) 2008; 19
Ding, Sigmund (CR50) 2001; 280
Abdo (CR51) 2014; 63
Hubner, Cavanagh-Kyros, Rincon, Flavell, Davis (CR38) 2010; 30
Marcussen (CR6) 2000; 15
Allen, Harwood, Varagunam, Raftery, Yaqoob (CR12) 2003; 17
CR53
Lo (CR19) 2012; 302
Morales (CR35) 2004; 18
Gilbert (CR4) 2017; 66
Lindop, Gibson, Downie, Vass, Cohen (CR7) 2002; 197
(CR23) 1993; 329
Schainuck, Striker, Cutler, Benditt (CR2) 1970; 1
Kang (CR11) 2003; 284
Hsieh (CR17) 2002; 143
Kumar, Robertson, Burns (CR14) 2004; 259
Drummond, Mauer (CR1) 2002; 51
Javaid, Olson, Meyer (CR5) 2001; 12
Day (CR36) 2004; 377
Coletta (CR45) 2008; 294
Abdo (CR30) 2013; 56
R Mishra (43218_CR15) 2005; 67
ML Brezniceanu (43218_CR20) 2007; 71
TJ Hsieh (43218_CR16) 2003; 144
DK Coletta (43218_CR45) 2008; 294
E Wang (43218_CR48) 2012; 7
Y Ding (43218_CR50) 2001; 280
DA Allen (43218_CR12) 2003; 17
GJ Lau (43218_CR22) 2012; 61
H Puthalakath (43218_CR33) 2001; 293
CS Lo (43218_CR47) 2015; 58
M Véniant (43218_CR52) 1994; 46
AA Morales (43218_CR35) 2004; 18
A Hubner (43218_CR38) 2010; 30
F Liu (43218_CR18) 2008; 19
M Yoshioka (43218_CR44) 1997; 46
S Abdo (43218_CR30) 2013; 56
A Ghosh (43218_CR31) 2017; 158
B Afsar (43218_CR41) 2018; 11
JR Schelling (43218_CR42) 2016; 31
B Najafian (43218_CR9) 2006; 17
K Drummond (43218_CR1) 2002; 51
S Nagata (43218_CR10) 1997; 88
S Abdo (43218_CR51) 2014; 63
LI Schainuck (43218_CR2) 1970; 1
IH de Boer (43218_CR24) 2008; 168
SS Tang (43218_CR55) 1995; 268
CC Wei (43218_CR27) 2006; 281
J Wang (43218_CR43) 1999; 103
TJ Hsieh (43218_CR17) 2002; 143
RE Gilbert (43218_CR4) 2017; 66
CS Lo (43218_CR28) 2012; 61
CC Wei (43218_CR26) 2005; 16
I Grgic (43218_CR40) 2012; 82
CL Day (43218_CR36) 2004; 377
B Javaid (43218_CR5) 2001; 12
HJG Gundersen (43218_CR54) 1988; 151
S Pfeiffer (43218_CR39) 2015; 1
CS Lo (43218_CR19) 2012; 302
The Diabetes Control and Complications Trial Research Group (43218_CR23) 1993; 329
N Marcussen (43218_CR6) 2000; 15
B Najafian (43218_CR8) 2003; 14
ML Brezniceanu (43218_CR21) 2008; 57
D Kumar (43218_CR13) 2004; 96
D Kumar (43218_CR14) 2004; 259
RE Gilbert (43218_CR3) 1999; 56
D Legouis (43218_CR34) 2015; 16
43218_CR53
GB Lindop (43218_CR7) 2002; 197
X Chen (43218_CR25) 2001; 142
BP Kang (43218_CR11) 2003; 284
CS Lo (43218_CR29) 2017; 66
E Korsheninnikova (43218_CR46) 2007; 113
H Puthalakath (43218_CR32) 2002; 9
V Labi (43218_CR37) 2008; 205
S Sachetelli (43218_CR49) 2006; 69
References_xml – volume: 12
  start-page: 1391
  year: 2001
  end-page: 1400
  ident: CR5
  article-title: Glomerular injury and tubular loss in adriamycin nephrosis
  publication-title: Journal of the American Society of Nephrology: JASN
  contributor:
    fullname: Meyer
– volume: 144
  start-page: 4338
  year: 2003
  end-page: 4349
  ident: CR16
  article-title: High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells
  publication-title: Endocrinology
  doi: 10.1210/en.2003-0220
  contributor:
    fullname: Hsieh
– volume: 151
  start-page: 3
  year: 1988
  end-page: 21
  ident: CR54
  article-title: The nucleator
  publication-title: J Microsc
  doi: 10.1111/j.1365-2818.1988.tb04609.x
  contributor:
    fullname: Gundersen
– volume: 284
  start-page: F455
  year: 2003
  end-page: 466
  ident: CR11
  article-title: High glucose promotes mesangial cell apoptosis by oxidant-dependent mechanism
  publication-title: American journal of physiology. Renal physiology
  doi: 10.1152/ajprenal.00137.2002
  contributor:
    fullname: Kang
– volume: 67
  start-page: 82
  year: 2005
  end-page: 93
  ident: CR15
  article-title: High glucose evokes an intrinsic proapoptotic signaling pathway in mesangial cells
  publication-title: Kidney international
  doi: 10.1111/j.1523-1755.2005.00058.x
  contributor:
    fullname: Simonson
– volume: 168
  start-page: 1867
  year: 2008
  end-page: 1873
  ident: CR24
  article-title: Insulin therapy, hyperglycemia, and hypertension in type 1 diabetes mellitus
  publication-title: Arch Intern Med
  doi: 10.1001/archinternmed.2008.2
  contributor:
    fullname: de Boer
– volume: 158
  start-page: 903
  year: 2017
  end-page: 919
  ident: CR31
  article-title: Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice
  publication-title: Endocrinology
  doi: 10.1210/en.2016-1576
  contributor:
    fullname: Ghosh
– volume: 293
  start-page: 1829
  year: 2001
  end-page: 1832
  ident: CR33
  article-title: Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
  publication-title: Science (New York, N.Y.)
  doi: 10.1126/science.1062257
  contributor:
    fullname: Puthalakath
– volume: 1
  year: 2015
  ident: CR39
  article-title: BH3-Only protein bmf is required for the maintenance of glucose homeostasis in an model of HNF1α-MODY diabetes
  publication-title: Cell Death Discovery
  doi: 10.1038/cddiscovery.2015.41
  contributor:
    fullname: Prehn
– volume: 63
  start-page: 3483
  year: 2014
  end-page: 3496
  ident: CR51
  article-title: Catalase overexpression prevents nuclear factor erythroid 2-related factor 2 stimulation of renal angiotensinogen gene expression
  publication-title: hypertension, and kidney injury in diabetic mice. Diabetes
  doi: 10.2337/db13-1830
  contributor:
    fullname: Abdo
– volume: 31
  start-page: 693
  year: 2016
  end-page: 706
  ident: CR42
  article-title: Tubular atrophy in the pathogenesis of chronic kidney disease progression
  publication-title: Pediatric nephrology (Berlin, Germany)
  doi: 10.1007/s00467-015-3169-4
  contributor:
    fullname: Schelling
– volume: 1
  start-page: 631
  year: 1970
  end-page: 641
  ident: CR2
  article-title: Structural-functional correlations in renal disease. II. The correlations
  publication-title: Human pathology
  doi: 10.1016/S0046-8177(70)80061-2
  contributor:
    fullname: Benditt
– volume: 143
  start-page: 2975
  year: 2002
  end-page: 2985
  ident: CR17
  article-title: High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells
  publication-title: Endocrinology
  doi: 10.1210/endo.143.8.8931
  contributor:
    fullname: Hsieh
– volume: 294
  start-page: E910
  year: 2008
  end-page: 917
  ident: CR45
  article-title: Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle .
  publication-title: Endocrinology and metabolism
  doi: 10.1152/ajpendo.00607.2007
  contributor:
    fullname: Coletta
– volume: 113
  start-page: 173
  year: 2007
  end-page: 185
  ident: CR46
  article-title: Dynamics of insulin signalling in liver during hyperinsulinemic euglycaemic clamp conditions and the effects of high-fat feeding in male mice
  publication-title: Archives of physiology and biochemistry
  doi: 10.1080/13813450701669084
  contributor:
    fullname: Korsheninnikova
– volume: 280
  start-page: F54
  year: 2001
  end-page: 60
  ident: CR50
  article-title: Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice
  publication-title: American journal of physiology. Renal physiology
  doi: 10.1152/ajprenal.2001.280.1.F54
  contributor:
    fullname: Sigmund
– volume: 19
  start-page: 269
  year: 2008
  end-page: 280
  ident: CR18
  article-title: Overexpression of angiotensinogen increases tubular apoptosis in diabetes
  publication-title: Journal of the American Society of Nephrology: JASN
  doi: 10.1681/ASN.2007010074
  contributor:
    fullname: Liu
– volume: 96
  start-page: e77
  year: 2004
  end-page: 88
  ident: CR13
  article-title: Tubular and interstitial cell apoptosis in the streptozotocin-diabetic rat kidney
  publication-title: Nephron. Experimental nephrology
  doi: 10.1159/000076749
  contributor:
    fullname: Burns
– volume: 302
  start-page: F840
  year: 2012
  end-page: 852
  ident: CR19
  article-title: Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice
  publication-title: American journal of physiology. Renal physiology
  doi: 10.1152/ajprenal.00340.2011
  contributor:
    fullname: Lo
– volume: 15
  start-page: 74
  issue: Suppl 6
  year: 2000
  end-page: 75
  ident: CR6
  article-title: Tubulointerstitial damage leads to atubular glomeruli: significance and possible role in progression
  publication-title: Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association
  doi: 10.1093/ndt/15.suppl_6.74
  contributor:
    fullname: Marcussen
– volume: 16
  start-page: 616
  year: 2005
  end-page: 628
  ident: CR26
  article-title: Heterogenous nuclear ribonucleoprotein F modulates angiotensinogen gene expression in rat kidney proximal tubular cells
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2004080715
  contributor:
    fullname: Chan
– volume: 9
  start-page: 505
  year: 2002
  end-page: 512
  ident: CR32
  article-title: Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
  publication-title: Cell death and differentiation
  doi: 10.1038/sj/cdd/4400998
  contributor:
    fullname: Strasser
– volume: 142
  start-page: 2577
  year: 2001
  end-page: 2585
  ident: CR25
  article-title: Characterization of a putative insulin-responsive element and its binding protein(s) in rat angiotensinogen gene promoter: regulation by glucose and insulin
  publication-title: Endocrinology
  doi: 10.1210/endo.142.6.8214
  contributor:
    fullname: Chen
– volume: 17
  start-page: S53
  year: 2006
  end-page: 60
  ident: CR9
  article-title: Glomerulotubular junction abnormalities are associated with proteinuria in type 1 diabetes
  publication-title: Journal of the American Society of Nephrology: JASN
  doi: 10.1681/asn.2005121342
  contributor:
    fullname: Mauer
– volume: 56
  start-page: 1649
  year: 2013
  end-page: 1660
  ident: CR30
  article-title: Heterogeneous nuclear ribonucleoproteins F and K mediate insulin inhibition of renal angiotensinogen gene expression and prevention of hypertension and kidney injury in diabetic mice
  publication-title: Diabetologia
  doi: 10.1007/s00125-013-2910-4
  contributor:
    fullname: Abdo
– volume: 205
  start-page: 641
  year: 2008
  end-page: 655
  ident: CR37
  article-title: Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development
  publication-title: The Journal of experimental medicine
  doi: 10.1084/jem.20071658
  contributor:
    fullname: Labi
– volume: 82
  start-page: 172
  year: 2012
  end-page: 183
  ident: CR40
  article-title: Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis
  publication-title: Kidney international
  doi: 10.1038/ki.2012.20
  contributor:
    fullname: Grgic
– volume: 57
  start-page: 451
  year: 2008
  end-page: 459
  ident: CR21
  article-title: Attenuation of interstitial fibrosis and tubular apoptosis in db/db transgenic mice overexpressing catalase in renal proximal tubular cells
  publication-title: Diabetes
  doi: 10.2337/db07-0013
  contributor:
    fullname: Brezniceanu
– volume: 18
  start-page: 41
  year: 2004
  end-page: 47
  ident: CR35
  article-title: Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells
  publication-title: Leukemia
  doi: 10.1038/sj.leu.2403183
  contributor:
    fullname: Morales
– volume: 58
  start-page: 2443
  year: 2015
  end-page: 2454
  ident: CR47
  article-title: Overexpression of heterogeneous nuclear ribonucleoprotein F stimulates renal Ace-2 gene expression and prevents TGF-beta1-induced kidney injury in a mouse model of diabetes
  publication-title: Diabetologia
  doi: 10.1007/s00125-015-3700-y
  contributor:
    fullname: Lo
– volume: 268
  start-page: F435
  year: 1995
  end-page: 446
  ident: CR55
  article-title: Temperature-sensitive SV40 immortalized rat proximal tubule cell line has functional renin-angiotensin system
  publication-title: The American journal of physiology
  contributor:
    fullname: Tang
– volume: 11
  start-page: 295
  year: 2018
  end-page: 301
  ident: CR41
  article-title: Capillary rarefaction from the kidney point of view
  publication-title: Clinical kidney journal
  doi: 10.1093/ckj/sfx133
  contributor:
    fullname: Afsar
– volume: 69
  start-page: 1016
  year: 2006
  end-page: 1023
  ident: CR49
  article-title: RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney
  publication-title: Kidney international
  doi: 10.1038/sj.ki.5000210
  contributor:
    fullname: Sachetelli
– volume: 46
  start-page: 887
  year: 1997
  end-page: 894
  ident: CR44
  article-title: A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
  publication-title: Diabetes
  doi: 10.2337/diab.46.5.887
  contributor:
    fullname: Koizumi
– ident: CR53
– volume: 56
  start-page: 1627
  year: 1999
  end-page: 1637
  ident: CR3
  article-title: The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury?
  publication-title: Kidney international
  doi: 10.1046/j.1523-1755.1999.00721.x
  contributor:
    fullname: Cooper
– volume: 61
  start-page: 2597
  year: 2012
  end-page: 2608
  ident: CR28
  article-title: Heterogeneous nuclear ribonucleoprotein F suppresses angiotensinogen gene expression and attenuates hypertension and kidney injury in diabetic mice
  publication-title: Diabetes
  doi: 10.2337/db11-1349
  contributor:
    fullname: Lo
– volume: 329
  start-page: 977
  year: 1993
  end-page: 986
  ident: CR23
  article-title: The effect of intensive treatment of diabetes on the development and progression of long term complications in insulin dependent diabetic mellitus
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199309303291401
– volume: 61
  start-page: 474
  year: 2012
  end-page: 484
  ident: CR22
  article-title: Bcl-2-modifying factor induces renal proximal tubular cell apoptosis in diabetic mice
  publication-title: Diabetes
  doi: 10.2337/db11-0141
  contributor:
    fullname: Lau
– volume: 51
  start-page: 1580
  year: 2002
  end-page: 1587
  ident: CR1
  article-title: The early natural history of nephropathy in type 1 diabetes: II. Early renal structural changes in type 1 diabetes
  publication-title: Diabetes
  doi: 10.2337/diabetes.51.5.1580
  contributor:
    fullname: Mauer
– volume: 17
  start-page: 908
  year: 2003
  end-page: 910
  ident: CR12
  article-title: High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases
  publication-title: FASEB journal: official publication of the Federation of American Societies for Experimental Biology
  doi: 10.1096/fj.02-0130fje
  contributor:
    fullname: Yaqoob
– volume: 259
  start-page: 67
  year: 2004
  end-page: 70
  ident: CR14
  article-title: Evidence of apoptosis in human diabetic kidney
  publication-title: Molecular and cellular biochemistry
  doi: 10.1023/B:MCBI.0000021346.03260.7e
  contributor:
    fullname: Burns
– volume: 197
  start-page: 1
  year: 2002
  end-page: 3
  ident: CR7
  article-title: The glomerulo-tubular junction: a target in renal diseases
  publication-title: The Journal of pathology
  doi: 10.1002/path.1087
  contributor:
    fullname: Cohen
– volume: 71
  start-page: 912
  year: 2007
  end-page: 923
  ident: CR20
  article-title: Catalase overexpression attenuates angiotensinogen expression and apoptosis in diabetic mice
  publication-title: Kidney international
  doi: 10.1038/sj.ki.5002188
  contributor:
    fullname: Brezniceanu
– volume: 281
  start-page: 25344
  year: 2006
  end-page: 25355
  ident: CR27
  article-title: Heterogeneous nuclear ribonucleoprotein K modulates angiotensinogen gene expression in kidney cells
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M601945200
  contributor:
    fullname: Wei
– volume: 377
  start-page: 597
  year: 2004
  end-page: 605
  ident: CR36
  article-title: Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands
  publication-title: The Biochemical journal
  doi: 10.1042/bj20031251
  contributor:
    fullname: Day
– volume: 46
  start-page: 421
  year: 1994
  end-page: 429
  ident: CR52
  article-title: Calcium blockade versus ACE inhibition in clipped and unclipped kidneys of 2K-1C rats
  publication-title: Kidney Int
  doi: 10.1038/ki.1994.290
  contributor:
    fullname: Ménard
– volume: 16
  year: 2015
  ident: CR34
  article-title: analysis of renal proximal tubular cells
  publication-title: BMC cell biology
  doi: 10.1186/s12860-015-0058-4
  contributor:
    fullname: Legouis
– volume: 103
  start-page: 27
  year: 1999
  end-page: 37
  ident: CR43
  article-title: A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse
  publication-title: The Journal of clinical investigation
  doi: 10.1172/jci4431
  contributor:
    fullname: Wang
– volume: 14
  start-page: 908
  year: 2003
  end-page: 917
  ident: CR8
  article-title: Atubular glomeruli and glomerulotubular junction abnormalities in diabetic nephropathy
  publication-title: Journal of the American Society of Nephrology: JASN
  doi: 10.1097/01.ASN.0000057854.32413.81
  contributor:
    fullname: Mauer
– volume: 66
  start-page: 1964
  year: 2017
  end-page: 1978
  ident: CR29
  article-title: Heterogeneous Nuclear Ribonucleoprotein F Stimulates Sirtuin-1 Gene Expression and Attenuates Nephropathy Progression in Diabetic Mice
  publication-title: Diabetes
  doi: 10.2337/db16-1588
  contributor:
    fullname: Lo
– volume: 7
  start-page: e51266
  year: 2012
  ident: CR48
  article-title: Global profiling of alternative splicing events and gene expression regulated by hnRNPH/F
  publication-title: PloS one
  doi: 10.1371/journal.pone.0051266
  contributor:
    fullname: Wang
– volume: 66
  start-page: 791
  year: 2017
  end-page: 800
  ident: CR4
  article-title: Proximal Tubulopathy: Prime Mover and Key Therapeutic Target in Diabetic Kidney Disease
  publication-title: Diabetes
  doi: 10.2337/db16-0796
  contributor:
    fullname: Gilbert
– volume: 30
  start-page: 98
  year: 2010
  end-page: 105
  ident: CR38
  article-title: Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim
  publication-title: Molecular and cellular biology
  doi: 10.1128/mcb.01155-09
  contributor:
    fullname: Davis
– volume: 88
  start-page: 355
  year: 1997
  end-page: 365
  ident: CR10
  article-title: Apoptosis by death factor
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81874-7
  contributor:
    fullname: Nagata
– volume: 284
  start-page: F455
  year: 2003
  ident: 43218_CR11
  publication-title: American journal of physiology. Renal physiology
  doi: 10.1152/ajprenal.00137.2002
  contributor:
    fullname: BP Kang
– volume: 82
  start-page: 172
  year: 2012
  ident: 43218_CR40
  publication-title: Kidney international
  doi: 10.1038/ki.2012.20
  contributor:
    fullname: I Grgic
– volume: 17
  start-page: 908
  year: 2003
  ident: 43218_CR12
  publication-title: FASEB journal: official publication of the Federation of American Societies for Experimental Biology
  doi: 10.1096/fj.02-0130fje
  contributor:
    fullname: DA Allen
– volume: 16
  start-page: 616
  year: 2005
  ident: 43218_CR26
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2004080715
  contributor:
    fullname: CC Wei
– volume: 66
  start-page: 791
  year: 2017
  ident: 43218_CR4
  publication-title: Diabetes
  doi: 10.2337/db16-0796
  contributor:
    fullname: RE Gilbert
– volume: 7
  start-page: e51266
  year: 2012
  ident: 43218_CR48
  publication-title: PloS one
  doi: 10.1371/journal.pone.0051266
  contributor:
    fullname: E Wang
– volume: 15
  start-page: 74
  issue: Suppl 6
  year: 2000
  ident: 43218_CR6
  publication-title: Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association
  doi: 10.1093/ndt/15.suppl_6.74
  contributor:
    fullname: N Marcussen
– volume: 377
  start-page: 597
  year: 2004
  ident: 43218_CR36
  publication-title: The Biochemical journal
  doi: 10.1042/bj20031251
  contributor:
    fullname: CL Day
– volume: 294
  start-page: E910
  year: 2008
  ident: 43218_CR45
  publication-title: Endocrinology and metabolism
  doi: 10.1152/ajpendo.00607.2007
  contributor:
    fullname: DK Coletta
– volume: 69
  start-page: 1016
  year: 2006
  ident: 43218_CR49
  publication-title: Kidney international
  doi: 10.1038/sj.ki.5000210
  contributor:
    fullname: S Sachetelli
– volume: 31
  start-page: 693
  year: 2016
  ident: 43218_CR42
  publication-title: Pediatric nephrology (Berlin, Germany)
  doi: 10.1007/s00467-015-3169-4
  contributor:
    fullname: JR Schelling
– volume: 17
  start-page: S53
  year: 2006
  ident: 43218_CR9
  publication-title: Journal of the American Society of Nephrology: JASN
  doi: 10.1681/asn.2005121342
  contributor:
    fullname: B Najafian
– volume: 71
  start-page: 912
  year: 2007
  ident: 43218_CR20
  publication-title: Kidney international
  doi: 10.1038/sj.ki.5002188
  contributor:
    fullname: ML Brezniceanu
– volume: 293
  start-page: 1829
  year: 2001
  ident: 43218_CR33
  publication-title: Science (New York, N.Y.)
  doi: 10.1126/science.1062257
  contributor:
    fullname: H Puthalakath
– volume: 11
  start-page: 295
  year: 2018
  ident: 43218_CR41
  publication-title: Clinical kidney journal
  doi: 10.1093/ckj/sfx133
  contributor:
    fullname: B Afsar
– volume: 61
  start-page: 2597
  year: 2012
  ident: 43218_CR28
  publication-title: Diabetes
  doi: 10.2337/db11-1349
  contributor:
    fullname: CS Lo
– volume: 158
  start-page: 903
  year: 2017
  ident: 43218_CR31
  publication-title: Endocrinology
  doi: 10.1210/en.2016-1576
  contributor:
    fullname: A Ghosh
– volume: 46
  start-page: 421
  year: 1994
  ident: 43218_CR52
  publication-title: Kidney Int
  doi: 10.1038/ki.1994.290
  contributor:
    fullname: M Véniant
– volume: 280
  start-page: F54
  year: 2001
  ident: 43218_CR50
  publication-title: American journal of physiology. Renal physiology
  doi: 10.1152/ajprenal.2001.280.1.F54
  contributor:
    fullname: Y Ding
– volume: 281
  start-page: 25344
  year: 2006
  ident: 43218_CR27
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M601945200
  contributor:
    fullname: CC Wei
– volume: 67
  start-page: 82
  year: 2005
  ident: 43218_CR15
  publication-title: Kidney international
  doi: 10.1111/j.1523-1755.2005.00058.x
  contributor:
    fullname: R Mishra
– volume: 1
  start-page: 631
  year: 1970
  ident: 43218_CR2
  publication-title: Human pathology
  doi: 10.1016/S0046-8177(70)80061-2
  contributor:
    fullname: LI Schainuck
– volume: 51
  start-page: 1580
  year: 2002
  ident: 43218_CR1
  publication-title: Diabetes
  doi: 10.2337/diabetes.51.5.1580
  contributor:
    fullname: K Drummond
– volume: 96
  start-page: e77
  year: 2004
  ident: 43218_CR13
  publication-title: Nephron. Experimental nephrology
  doi: 10.1159/000076749
  contributor:
    fullname: D Kumar
– volume: 143
  start-page: 2975
  year: 2002
  ident: 43218_CR17
  publication-title: Endocrinology
  doi: 10.1210/endo.143.8.8931
  contributor:
    fullname: TJ Hsieh
– volume: 61
  start-page: 474
  year: 2012
  ident: 43218_CR22
  publication-title: Diabetes
  doi: 10.2337/db11-0141
  contributor:
    fullname: GJ Lau
– volume: 58
  start-page: 2443
  year: 2015
  ident: 43218_CR47
  publication-title: Diabetologia
  doi: 10.1007/s00125-015-3700-y
  contributor:
    fullname: CS Lo
– volume: 19
  start-page: 269
  year: 2008
  ident: 43218_CR18
  publication-title: Journal of the American Society of Nephrology: JASN
  doi: 10.1681/ASN.2007010074
  contributor:
    fullname: F Liu
– volume: 16
  year: 2015
  ident: 43218_CR34
  publication-title: BMC cell biology
  doi: 10.1186/s12860-015-0058-4
  contributor:
    fullname: D Legouis
– volume: 30
  start-page: 98
  year: 2010
  ident: 43218_CR38
  publication-title: Molecular and cellular biology
  doi: 10.1128/mcb.01155-09
  contributor:
    fullname: A Hubner
– volume: 113
  start-page: 173
  year: 2007
  ident: 43218_CR46
  publication-title: Archives of physiology and biochemistry
  doi: 10.1080/13813450701669084
  contributor:
    fullname: E Korsheninnikova
– volume: 142
  start-page: 2577
  year: 2001
  ident: 43218_CR25
  publication-title: Endocrinology
  doi: 10.1210/endo.142.6.8214
  contributor:
    fullname: X Chen
– volume: 144
  start-page: 4338
  year: 2003
  ident: 43218_CR16
  publication-title: Endocrinology
  doi: 10.1210/en.2003-0220
  contributor:
    fullname: TJ Hsieh
– volume: 12
  start-page: 1391
  year: 2001
  ident: 43218_CR5
  publication-title: Journal of the American Society of Nephrology: JASN
  doi: 10.1681/ASN.V1271391
  contributor:
    fullname: B Javaid
– volume: 46
  start-page: 887
  year: 1997
  ident: 43218_CR44
  publication-title: Diabetes
  doi: 10.2337/diab.46.5.887
  contributor:
    fullname: M Yoshioka
– volume: 9
  start-page: 505
  year: 2002
  ident: 43218_CR32
  publication-title: Cell death and differentiation
  doi: 10.1038/sj/cdd/4400998
  contributor:
    fullname: H Puthalakath
– volume: 66
  start-page: 1964
  year: 2017
  ident: 43218_CR29
  publication-title: Diabetes
  doi: 10.2337/db16-1588
  contributor:
    fullname: CS Lo
– ident: 43218_CR53
– volume: 259
  start-page: 67
  year: 2004
  ident: 43218_CR14
  publication-title: Molecular and cellular biochemistry
  doi: 10.1023/B:MCBI.0000021346.03260.7e
  contributor:
    fullname: D Kumar
– volume: 197
  start-page: 1
  year: 2002
  ident: 43218_CR7
  publication-title: The Journal of pathology
  doi: 10.1002/path.1087
  contributor:
    fullname: GB Lindop
– volume: 88
  start-page: 355
  year: 1997
  ident: 43218_CR10
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81874-7
  contributor:
    fullname: S Nagata
– volume: 329
  start-page: 977
  year: 1993
  ident: 43218_CR23
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199309303291401
  contributor:
    fullname: The Diabetes Control and Complications Trial Research Group
– volume: 268
  start-page: F435
  year: 1995
  ident: 43218_CR55
  publication-title: The American journal of physiology
  contributor:
    fullname: SS Tang
– volume: 103
  start-page: 27
  year: 1999
  ident: 43218_CR43
  publication-title: The Journal of clinical investigation
  doi: 10.1172/jci4431
  contributor:
    fullname: J Wang
– volume: 168
  start-page: 1867
  year: 2008
  ident: 43218_CR24
  publication-title: Arch Intern Med
  doi: 10.1001/archinternmed.2008.2
  contributor:
    fullname: IH de Boer
– volume: 56
  start-page: 1627
  year: 1999
  ident: 43218_CR3
  publication-title: Kidney international
  doi: 10.1046/j.1523-1755.1999.00721.x
  contributor:
    fullname: RE Gilbert
– volume: 302
  start-page: F840
  year: 2012
  ident: 43218_CR19
  publication-title: American journal of physiology. Renal physiology
  doi: 10.1152/ajprenal.00340.2011
  contributor:
    fullname: CS Lo
– volume: 57
  start-page: 451
  year: 2008
  ident: 43218_CR21
  publication-title: Diabetes
  doi: 10.2337/db07-0013
  contributor:
    fullname: ML Brezniceanu
– volume: 205
  start-page: 641
  year: 2008
  ident: 43218_CR37
  publication-title: The Journal of experimental medicine
  doi: 10.1084/jem.20071658
  contributor:
    fullname: V Labi
– volume: 63
  start-page: 3483
  year: 2014
  ident: 43218_CR51
  publication-title: hypertension, and kidney injury in diabetic mice. Diabetes
  doi: 10.2337/db13-1830
  contributor:
    fullname: S Abdo
– volume: 151
  start-page: 3
  year: 1988
  ident: 43218_CR54
  publication-title: J Microsc
  doi: 10.1111/j.1365-2818.1988.tb04609.x
  contributor:
    fullname: HJG Gundersen
– volume: 1
  year: 2015
  ident: 43218_CR39
  publication-title: Cell Death Discovery
  doi: 10.1038/cddiscovery.2015.41
  contributor:
    fullname: S Pfeiffer
– volume: 14
  start-page: 908
  year: 2003
  ident: 43218_CR8
  publication-title: Journal of the American Society of Nephrology: JASN
  doi: 10.1097/01.ASN.0000057854.32413.81
  contributor:
    fullname: B Najafian
– volume: 56
  start-page: 1649
  year: 2013
  ident: 43218_CR30
  publication-title: Diabetologia
  doi: 10.1007/s00125-013-2910-4
  contributor:
    fullname: S Abdo
– volume: 18
  start-page: 41
  year: 2004
  ident: 43218_CR35
  publication-title: Leukemia
  doi: 10.1038/sj.leu.2403183
  contributor:
    fullname: AA Morales
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Snippet We investigated the molecular mechanism(s) by which insulin prevents Bcl2-modifying factor (Bmf)-induced renal proximal tubular cell (RPTC) apoptosis and loss...
Abstract We investigated the molecular mechanism(s) by which insulin prevents Bcl2-modifying factor (Bmf)-induced renal proximal tubular cell (RPTC) apoptosis...
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Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - metabolism
Animals
Apoptosis
Apoptosis - drug effects
Apoptosis - genetics
Biomarkers
Blood pressure
Blood Pressure - genetics
Creatinine
Diabetes
Diabetes mellitus
Diabetic Nephropathies - etiology
Diabetic Nephropathies - metabolism
Diabetic Nephropathies - pathology
Disease Models, Animal
Gene Expression Regulation - drug effects
Genetic Loci
Glucose - metabolism
Heterogeneous-Nuclear Ribonucleoprotein Group F-H - metabolism
Humanities and Social Sciences
Humans
Immunohistochemistry
Insulin
Insulin - metabolism
Insulin - pharmacology
Kidney Tubules, Proximal - metabolism
Kidney Tubules, Proximal - pathology
Kidneys
Kinases
MAP kinase
Mice
Mice, Transgenic
multidisciplinary
Protein kinase
Regulatory sequences
Science
Science (multidisciplinary)
siRNA
Transcription
Transfection
Transgenic mice
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Title Heterogeneous Nuclear Ribonucleoprotein F Mediates Insulin Inhibition of Bcl2-Modifying Factor Expression and Tubulopathy in Diabetic Kidney
URI https://link.springer.com/article/10.1038/s41598-019-43218-2
https://www.ncbi.nlm.nih.gov/pubmed/31040360
https://www.proquest.com/docview/2217462153
https://pubmed.ncbi.nlm.nih.gov/PMC6491582
Volume 9
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