HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide

• Published in: Cell reports (Cambridge) Vol. 42; no. 7; p. 112755
• Main Authors: Wang, Shuishu, Matassoli, Flavio, Zhang, Baoshan, Liu, Tracy, Shen, Chen-Hsiang, Bylund, Tatsiana, Johnston, Timothy, Henry, Amy R., Teng, I-Ting, Tripathi, Prabhanshu, Becker, Jordan E., Changela, Anita, Chaudhary, Ridhi, Cheng, Cheng, Gaudinski, Martin, Gorman, Jason, Harris, Darcy R., Lee, Myungjin, Morano, Nicholas C., Novik, Laura, O’Dell, Sijy, Olia, Adam S., Parchment, Danealle K., Rawi, Reda, Roberts-Torres, Jesmine, Stephens, Tyler, Tsybovsky, Yaroslav, Wang, Danyi, Van Wazer, David J., Zhou, Tongqing, Doria-Rose, Nicole A., Koup, Richard A., Shapiro, Lawrence, Douek, Daniel C., McDermott, Adrian B., Kwong, Peter D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.07.2023; Elsevier
• Subjects: AIDS Vaccines; Antibodies, Neutralizing; antibody-antigen binding; CP: Immunology; cryo-EM structure; env Gene Products, Human Immunodeficiency Virus; envelope trimer; fusion peptide; glycan hole; HIV Antibodies; HIV Infections; HIV Seropositivity; HIV vaccine; HIV-1; Humans; immunogen design; Peptides; reproducible antibody class; site of vulnerability; CP: Immunology; fusion peptide; antibody-antigen binding; glycan hole; immunogen design; cryo-EM structure; HIV vaccine; envelope trimer; reproducible antibody class; site of vulnerability

Elicitation of antibodies that neutralize the tier-2 neutralization-resistant isolates that typify HIV-1 transmission has been a long-sought goal. Success with prefusion-stabilized envelope trimers eliciting autologous neutralizing antibodies has been reported in multiple vaccine-test species, thoug...