Two Pituitary Neuroendocrine Tumors (PitNETs) with Very High Proliferation and TP53 Mutation — High-Grade PitNET or PitNEC?

• Published in: Endocrine pathology Vol. 33; no. 2; pp. 257 - 262
• Main Authors: Saeger, Wolfgang, Mawrin, Christian, Meinhardt, Matthias, Wefers, Annika K., Jacobsen, Frank
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2022; Springer Nature B.V
• Subjects: Bone tumors; Brain cancer; Carcinoma; Endocrinology; Gastrointestinal tract; Medicine; Medicine & Public Health; Metastases; Metastasis; Mitosis; Mutation; Neuroendocrine tumors; Oncology; Pathology; Pituitary; Prolactin; PitNEC; PitNET; Pituitary; Neuroendocrine carcinoma

We report two pituitary neuroendocrine tumors (PitNETs) with very high Ki67 labeling indices, many mitoses and TP53 mutation (nearly all tumor cell nuclei were positive for p53). One of the tumors had bone and liver metastases. One was a corticotroph cell tumor; the other was a lactotroph tumor. The...