Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people

• Published in: Aging clinical and experimental research Vol. 33; no. 4; pp. 759 - 773
• Main Authors: Barnsley, J., Buckland, G., Chan, P. E., Ong, A., Ramos, A. S., Baxter, M., Laskou, F., Dennison, E. M., Cooper, C., Patel, Harnish P.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2021; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Bone diseases; Bone Diseases, Metabolic; Clinical medicine; Fractures; Fractures, Bone; Geriatrics/Gerontology; Homeostasis; Hospitals; Humans; Hydroxyapatite; Medicine; Medicine & Public Health; Metabolism; Morbidity; Mortality; Older people; Osteoporosis; Osteoporosis - drug therapy; Pathophysiology; Prevalence; Proteins; Review; Sarcopenia; Osteoporosis; Older People; Treatment; Pathophysiology; Bone development; Osteosarcopenia

Osteoporosis, a common chronic metabolic bone disease is associated with considerable morbidity and mortality. As the prevalence of osteoporosis increases with age, a paralleled elevation in the rate of incident fragility fractures will be observed. This narrative review explores the origins of bone...