Nutritional status modifies pregnane X receptor regulated transcriptome
Pregnane X receptor (PXR) regulates glucose and lipid metabolism, but little is known of the nutritional regulation of PXR function. We investigated the genome wide effects of the nutritional status on the PXR mediated gene regulation in the liver. Mice were treated with a PXR ligand pregnenolone 16...
Saved in:
Published in | Scientific reports Vol. 9; no. 1; pp. 16728 - 13 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
13.11.2019
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Pregnane X receptor (PXR) regulates glucose and lipid metabolism, but little is known of the nutritional regulation of PXR function. We investigated the genome wide effects of the nutritional status on the PXR mediated gene regulation in the liver. Mice were treated with a PXR ligand pregnenolone 16α-carbonitrile (PCN) for 4 days and subsequently either fasted for 5 hours or after 4-hour fast treated with intragastric glucose 1 hour before sample collection. Gene expression microarray study indicated that PCN both induced and repressed much higher number of genes in the glucose fed mice and the induction of multiple well-established PXR target genes was potentiated by glucose. A subset of genes, including bile acid synthesis gene
Cyp8b1
, responded in an opposite direction during fasting and after glucose feeding. PXR knockout abolished these effects. In agreement with the
Cyp8b1
regulation, PCN also modified the bile acid composition in the glucose fed mice. Contribution of glucose, insulin and glucagon on the observed nutritional effects was investigated in primary hepatocytes. However, only mild impact on PXR function was observed. These results show that nutritional status modifies the PXR regulated transcriptome both qualitatively and quantitatively and reveal a complex crosstalk between PXR and energy homeostasis. |
---|---|
AbstractList | Pregnane X receptor (PXR) regulates glucose and lipid metabolism, but little is known of the nutritional regulation of PXR function. We investigated the genome wide effects of the nutritional status on the PXR mediated gene regulation in the liver. Mice were treated with a PXR ligand pregnenolone 16α-carbonitrile (PCN) for 4 days and subsequently either fasted for 5 hours or after 4-hour fast treated with intragastric glucose 1 hour before sample collection. Gene expression microarray study indicated that PCN both induced and repressed much higher number of genes in the glucose fed mice and the induction of multiple well-established PXR target genes was potentiated by glucose. A subset of genes, including bile acid synthesis gene
Cyp8b1
, responded in an opposite direction during fasting and after glucose feeding. PXR knockout abolished these effects. In agreement with the
Cyp8b1
regulation, PCN also modified the bile acid composition in the glucose fed mice. Contribution of glucose, insulin and glucagon on the observed nutritional effects was investigated in primary hepatocytes. However, only mild impact on PXR function was observed. These results show that nutritional status modifies the PXR regulated transcriptome both qualitatively and quantitatively and reveal a complex crosstalk between PXR and energy homeostasis. Pregnane X receptor (PXR) regulates glucose and lipid metabolism, but little is known of the nutritional regulation of PXR function. We investigated the genome wide effects of the nutritional status on the PXR mediated gene regulation in the liver. Mice were treated with a PXR ligand pregnenolone 16α-carbonitrile (PCN) for 4 days and subsequently either fasted for 5 hours or after 4-hour fast treated with intragastric glucose 1 hour before sample collection. Gene expression microarray study indicated that PCN both induced and repressed much higher number of genes in the glucose fed mice and the induction of multiple well-established PXR target genes was potentiated by glucose. A subset of genes, including bile acid synthesis gene Cyp8b1, responded in an opposite direction during fasting and after glucose feeding. PXR knockout abolished these effects. In agreement with the Cyp8b1 regulation, PCN also modified the bile acid composition in the glucose fed mice. Contribution of glucose, insulin and glucagon on the observed nutritional effects was investigated in primary hepatocytes. However, only mild impact on PXR function was observed. These results show that nutritional status modifies the PXR regulated transcriptome both qualitatively and quantitatively and reveal a complex crosstalk between PXR and energy homeostasis. Abstract Pregnane X receptor (PXR) regulates glucose and lipid metabolism, but little is known of the nutritional regulation of PXR function. We investigated the genome wide effects of the nutritional status on the PXR mediated gene regulation in the liver. Mice were treated with a PXR ligand pregnenolone 16α-carbonitrile (PCN) for 4 days and subsequently either fasted for 5 hours or after 4-hour fast treated with intragastric glucose 1 hour before sample collection. Gene expression microarray study indicated that PCN both induced and repressed much higher number of genes in the glucose fed mice and the induction of multiple well-established PXR target genes was potentiated by glucose. A subset of genes, including bile acid synthesis gene Cyp8b1 , responded in an opposite direction during fasting and after glucose feeding. PXR knockout abolished these effects. In agreement with the Cyp8b1 regulation, PCN also modified the bile acid composition in the glucose fed mice. Contribution of glucose, insulin and glucagon on the observed nutritional effects was investigated in primary hepatocytes. However, only mild impact on PXR function was observed. These results show that nutritional status modifies the PXR regulated transcriptome both qualitatively and quantitatively and reveal a complex crosstalk between PXR and energy homeostasis. |
ArticleNumber | 16728 |
Author | Hassani-Nezhad-Gashti, Fatemeh Kummu, Outi Hakkola, Jukka Rysä, Jaana Karpale, Mikko |
Author_xml | – sequence: 1 givenname: Fatemeh surname: Hassani-Nezhad-Gashti fullname: Hassani-Nezhad-Gashti, Fatemeh organization: Research Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu, Medical Research Center Oulu, Oulu University Hospital and University of Oulu – sequence: 2 givenname: Outi surname: Kummu fullname: Kummu, Outi organization: Research Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu, Medical Research Center Oulu, Oulu University Hospital and University of Oulu – sequence: 3 givenname: Mikko surname: Karpale fullname: Karpale, Mikko organization: Research Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu, Medical Research Center Oulu, Oulu University Hospital and University of Oulu – sequence: 4 givenname: Jaana orcidid: 0000-0003-2205-6323 surname: Rysä fullname: Rysä, Jaana organization: School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland – sequence: 5 givenname: Jukka orcidid: 0000-0001-5048-4363 surname: Hakkola fullname: Hakkola, Jukka email: jukka.hakkola@oulu.fi organization: Research Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu, Medical Research Center Oulu, Oulu University Hospital and University of Oulu |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31723190$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kE1LAzEQhoNUtFb_gAdZ8Lyaycd2cxGkaBWKXhS8hTQ7W1fapCZZwX9vtH5eDCEZMu-8M3n2yMB5h4QcAj0ByuvTKECquqSgSsmBQqm2yJBRIUvGGRv8infJQYxPNC_JlAC1Q3Y5jBkHRYdketOn0KXOO7MsYjKpj8XKN13bYSzWARfOOCweioAW18mHHCz6pUnYFCkYF23o8vMK98l2a5YRDz7vEbm_vLibXJWz2-n15HxWWjEWqZQgKznmtZRQj1s7Z43lXLRzY6oGmFBKUgmiBptnrQBFXTOLCuYGqLTSIh-Rs43vup-vsLHo8hhLvQ7dyoRX7U2n_2Zc96gX_kVXteSq4tng-NMg-OceY9JPvg_591FnJCJvls8RYRuVDT7GgO13B6D6nb_e8NeZv_7gr1UuOvo923fJF-0s4BtBzCm3wPDT-x_bN6C9kt8 |
CitedBy_id | crossref_primary_10_1111_bph_15433 crossref_primary_10_3390_cells11030313 crossref_primary_10_3390_molecules27227830 crossref_primary_10_1002_jat_4538 crossref_primary_10_1016_j_gene_2022_147039 crossref_primary_10_1016_j_bbrc_2022_05_055 crossref_primary_10_1007_s00204_023_03575_4 crossref_primary_10_3389_fendo_2020_00488 crossref_primary_10_1016_j_phymed_2024_155432 crossref_primary_10_3390_cells9102306 crossref_primary_10_1124_dmd_122_000862 crossref_primary_10_3390_cells9112445 |
Cites_doi | 10.1038/clpt.2013.48 10.1016/S0300-483X(00)00300-0 10.1016/j.bbrc.2011.02.048 10.1074/jbc.M405423200 10.3390/nu10080982 10.3109/03602532.2012.740049 10.1042/BJ20070481 10.1016/j.addr.2010.08.006 10.1016/j.livres.2017.05.001 10.1242/jcs.062638 10.1124/dmd.31.11.1296 10.1128/MCB.24.18.7931-7940.2004 10.1097/FPC.0b013e3282f706e0 10.1016/j.bbagrm.2016.02.015 10.1124/mol.117.110155 10.1016/j.bbagrm.2016.01.006 10.1016/j.cellsig.2017.09.003 10.1016/j.bcp.2011.09.006 10.1074/jbc.M610072200 10.1124/jpet.106.107573 10.1038/srep46751 10.2337/db12-1039 10.1016/j.bbagrm.2016.03.012 10.1073/pnas.051551698 10.1016/j.bcp.2018.01.001 10.1053/j.gastro.2017.01.055 |
ContentType | Journal Article |
Copyright | The Author(s) 2019 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
Copyright_xml | – notice: The Author(s) 2019 – notice: 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
DBID | C6C CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PIMPY PQEST PQQKQ PQUKI PRINS Q9U 5PM |
DOI | 10.1038/s41598-019-53101-9 |
DatabaseName | SpringerOpen Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) ProQuest_Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central ProQuest Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest Science Journals Biological Science Database Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) |
DatabaseTitleList | MEDLINE CrossRef Publicly Available Content Database |
Database_xml | – sequence: 1 dbid: C6C name: SpringerOpen url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 2045-2322 |
EndPage | 13 |
ExternalDocumentID | 10_1038_s41598_019_53101_9 31723190 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GrantInformation_xml | – fundername: Diabetes research foundation, Finland – fundername: Academy of Finland (Suomen Akatemia) grantid: 286743 funderid: https://doi.org/10.13039/501100002341 – fundername: Novo Nordisk Fonden (Novo Nordisk Foundation) grantid: NNF14OC0010653; NNF15OC0015846 funderid: https://doi.org/10.13039/501100009708 – fundername: ; – fundername: ; grantid: NNF14OC0010653; NNF15OC0015846 – fundername: ; grantid: 286743 |
GroupedDBID | 0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ADBBV ADRAZ AENEX AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS EJD ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RIG RNT RNTTT RPM SNYQT UKHRP AFPKN CGR CUY CVF ECM EIF NPM AAYXX CITATION 7XB 8FK K9. PQEST PQUKI PRINS Q9U 5PM |
ID | FETCH-LOGICAL-c474t-5156573855187fcb2dc334fbaa6d124995051481c05261e4882ce91ba105c5ce3 |
IEDL.DBID | RPM |
ISSN | 2045-2322 |
IngestDate | Tue Sep 17 21:10:04 EDT 2024 Thu Oct 10 23:02:01 EDT 2024 Fri Aug 23 01:26:55 EDT 2024 Sat Sep 28 08:25:42 EDT 2024 Fri Oct 11 20:46:26 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c474t-5156573855187fcb2dc334fbaa6d124995051481c05261e4882ce91ba105c5ce3 |
ORCID | 0000-0001-5048-4363 0000-0003-2205-6323 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853963/ |
PMID | 31723190 |
PQID | 2314314214 |
PQPubID | 2041939 |
PageCount | 13 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6853963 proquest_journals_2314314214 crossref_primary_10_1038_s41598_019_53101_9 pubmed_primary_31723190 springer_journals_10_1038_s41598_019_53101_9 |
PublicationCentury | 2000 |
PublicationDate | 2019-11-13 |
PublicationDateYYYYMMDD | 2019-11-13 |
PublicationDate_xml | – month: 11 year: 2019 text: 2019-11-13 day: 13 |
PublicationDecade | 2010 |
PublicationPlace | London |
PublicationPlace_xml | – name: London – name: England |
PublicationTitle | Scientific reports |
PublicationTitleAbbrev | Sci Rep |
PublicationTitleAlternate | Sci Rep |
PublicationYear | 2019 |
Publisher | Nature Publishing Group UK Nature Publishing Group |
Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
References | Chiang (CR21) 2017; 1 Itoh (CR27) 2006; 319 Chávez-Talavera, Tailleux, Lefebvre, Staels (CR25) 2017; 152 Hakkola, Rysä, Hukkanen (CR3) 2016; 1859 Hassani-Nezhad-Gashti (CR7) 2018; 148 Kodama, Moore, Yamamoto, Negishi (CR5) 2007; 407 Oladimeji, Chen (CR4) 2018; 93 Wallace, Redinbo (CR1) 2013; 45 Gotoh, Miyauchi, Moore, Negishi (CR15) 2017; 40 Oladimeji, Lin, Brewer, Chen (CR26) 2017; 7 He (CR10) 2013; 62 Ben-Ari (CR18) 2010; 123 Staudinger (CR22) 2001; 98 Nakamura, Moore, Negishi, Sueyoshi (CR9) 2007; 282 Bhalla, Ozalp, Fang, Xiang, Kemper (CR16) 2004; 279 Kodama, Koike, Negishi, Yamamoto (CR6) 2004; 24 Pasquel (CR14) 2016; 1859 Zhou (CR17) 2016; 1859 Buler, Aatsinki, Skoumal, Hakkola (CR11) 2011; 82 Teng, Jekerle, Piquette-Miller (CR23) 2003; 31 Moore, Kliewer (CR2) 2000; 153 Roth, Looser, Kaufmann, Meyer (CR12) 2008; 18 Rysä (CR8) 2013; 93 Biswas, Pasquel, Tyagi, Mani (CR13) 2011; 406 Tolson, Wang (CR19) 2010; 62 Sultana (CR24) 2018; 10 Staudinger, Liu, Madan, Habeebu, Klaassen (CR20) 2001; 29 BD Wallace (53101_CR1) 2013; 45 A Biswas (53101_CR13) 2011; 406 AH Tolson (53101_CR19) 2010; 62 J Staudinger (53101_CR20) 2001; 29 J Hakkola (53101_CR3) 2016; 1859 K Nakamura (53101_CR9) 2007; 282 PO Oladimeji (53101_CR26) 2017; 7 S Teng (53101_CR23) 2003; 31 M Buler (53101_CR11) 2011; 82 S Kodama (53101_CR5) 2007; 407 H Sultana (53101_CR24) 2018; 10 Y Ben-Ari (53101_CR18) 2010; 123 D Pasquel (53101_CR14) 2016; 1859 S Kodama (53101_CR6) 2004; 24 J He (53101_CR10) 2013; 62 PO Oladimeji (53101_CR4) 2018; 93 S Gotoh (53101_CR15) 2017; 40 J Rysä (53101_CR8) 2013; 93 O Chávez-Talavera (53101_CR25) 2017; 152 F Hassani-Nezhad-Gashti (53101_CR7) 2018; 148 S Bhalla (53101_CR16) 2004; 279 M Itoh (53101_CR27) 2006; 319 JT Moore (53101_CR2) 2000; 153 A Roth (53101_CR12) 2008; 18 C Zhou (53101_CR17) 2016; 1859 JYL Chiang (53101_CR21) 2017; 1 JL Staudinger (53101_CR22) 2001; 98 |
References_xml | – volume: 93 start-page: 556 year: 2013 end-page: 563 ident: CR8 article-title: Pregnane X receptor agonists impair postprandial glucose tolerance publication-title: Clin. Pharmacol. Ther. doi: 10.1038/clpt.2013.48 contributor: fullname: Rysä – volume: 153 start-page: 1 year: 2000 end-page: 10 ident: CR2 article-title: Use of the nuclear receptor PXR to predict drug interactions publication-title: Toxicology doi: 10.1016/S0300-483X(00)00300-0 contributor: fullname: Kliewer – volume: 406 start-page: 371 year: 2011 end-page: 376 ident: CR13 article-title: Acetylation of pregnane X receptor protein determines selective function independent of ligand activation publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2011.02.048 contributor: fullname: Mani – volume: 29 start-page: 1467 year: 2001 end-page: 1472 ident: CR20 article-title: Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor publication-title: Drug Metab. Dispos. contributor: fullname: Klaassen – volume: 279 start-page: 45139 year: 2004 end-page: 45147 ident: CR16 article-title: Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism publication-title: J. Biol. Chem. doi: 10.1074/jbc.M405423200 contributor: fullname: Kemper – volume: 10 start-page: 982 year: 2018 ident: CR24 article-title: Effects of Vitamin K on the Expression of Genes Involved in Bile Acid Synthesis and Glucose Homeostasis in Mice with Humanized PXR publication-title: Nutrients doi: 10.3390/nu10080982 contributor: fullname: Sultana – volume: 45 start-page: 79 year: 2013 end-page: 100 ident: CR1 article-title: Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective publication-title: Drug Metab. Rev. doi: 10.3109/03602532.2012.740049 contributor: fullname: Redinbo – volume: 407 start-page: 373 year: 2007 end-page: 381 ident: CR5 article-title: Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene publication-title: Biochem. J. doi: 10.1042/BJ20070481 contributor: fullname: Negishi – volume: 62 start-page: 1238 year: 2010 end-page: 1249 ident: CR19 article-title: Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2010.08.006 contributor: fullname: Wang – volume: 1 start-page: 3 year: 2017 end-page: 9 ident: CR21 article-title: Bile acid metabolism and signaling in liver disease and therapy publication-title: Liver Res doi: 10.1016/j.livres.2017.05.001 contributor: fullname: Chiang – volume: 123 start-page: 1761 year: 2010 end-page: 1774 ident: CR18 article-title: The life of an mRNA in space and time publication-title: J. Cell. Sci. doi: 10.1242/jcs.062638 contributor: fullname: Ben-Ari – volume: 31 start-page: 1296 year: 2003 end-page: 1299 ident: CR23 article-title: Induction of ABCC3 (MRP3) by pregnane X receptor activators publication-title: Drug Metab. Dispos. doi: 10.1124/dmd.31.11.1296 contributor: fullname: Piquette-Miller – volume: 24 start-page: 7931 year: 2004 end-page: 7940 ident: CR6 article-title: Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.18.7931-7940.2004 contributor: fullname: Yamamoto – volume: 18 start-page: 325 year: 2008 end-page: 337 ident: CR12 article-title: Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes publication-title: Pharmacogenet. Genomics doi: 10.1097/FPC.0b013e3282f706e0 contributor: fullname: Meyer – volume: 1859 start-page: 1112 year: 2016 end-page: 1120 ident: CR17 article-title: Novel functions of PXR in cardiometabolic disease publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagrm.2016.02.015 contributor: fullname: Zhou – volume: 93 start-page: 119 year: 2018 end-page: 127 ident: CR4 article-title: PXR: More Than Just a Master Xenobiotic Receptor publication-title: Mol. Pharmacol. doi: 10.1124/mol.117.110155 contributor: fullname: Chen – volume: 1859 start-page: 1155 year: 2016 end-page: 1169 ident: CR14 article-title: Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagrm.2016.01.006 contributor: fullname: Pasquel – volume: 40 start-page: 200 year: 2017 end-page: 209 ident: CR15 article-title: Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal publication-title: Cell. Signal. doi: 10.1016/j.cellsig.2017.09.003 contributor: fullname: Negishi – volume: 82 start-page: 2008 year: 2011 end-page: 2015 ident: CR11 article-title: Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2011.09.006 contributor: fullname: Hakkola – volume: 282 start-page: 9768 year: 2007 end-page: 9776 ident: CR9 article-title: Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver publication-title: J. Biol. Chem. doi: 10.1074/jbc.M610072200 contributor: fullname: Sueyoshi – volume: 319 start-page: 693 year: 2006 end-page: 702 ident: CR27 article-title: Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha publication-title: J. Pharmacol. Exp. Ther. doi: 10.1124/jpet.106.107573 contributor: fullname: Itoh – volume: 7 year: 2017 ident: CR26 article-title: Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase publication-title: Sci Rep doi: 10.1038/srep46751 contributor: fullname: Chen – volume: 62 start-page: 1876 year: 2013 end-page: 1887 ident: CR10 article-title: PXR ablation alleviates diet-induced and genetic obesity and insulin resistance in mice publication-title: Diabetes doi: 10.2337/db12-1039 contributor: fullname: He – volume: 1859 start-page: 1072 year: 2016 end-page: 1082 ident: CR3 article-title: Regulation of hepatic energy metabolism by the nuclear receptor PXR publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagrm.2016.03.012 contributor: fullname: Hukkanen – volume: 98 start-page: 3369 year: 2001 end-page: 3374 ident: CR22 article-title: The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.051551698 contributor: fullname: Staudinger – volume: 148 start-page: 253 year: 2018 end-page: 264 ident: CR7 article-title: Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2018.01.001 contributor: fullname: Hassani-Nezhad-Gashti – volume: 152 start-page: 1679 year: 2017 end-page: 1694 ident: CR25 article-title: Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease publication-title: Gastroenterology doi: 10.1053/j.gastro.2017.01.055 contributor: fullname: Staels – volume: 82 start-page: 2008 year: 2011 ident: 53101_CR11 publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2011.09.006 contributor: fullname: M Buler – volume: 279 start-page: 45139 year: 2004 ident: 53101_CR16 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M405423200 contributor: fullname: S Bhalla – volume: 148 start-page: 253 year: 2018 ident: 53101_CR7 publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2018.01.001 contributor: fullname: F Hassani-Nezhad-Gashti – volume: 282 start-page: 9768 year: 2007 ident: 53101_CR9 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M610072200 contributor: fullname: K Nakamura – volume: 40 start-page: 200 year: 2017 ident: 53101_CR15 publication-title: Cell. Signal. doi: 10.1016/j.cellsig.2017.09.003 contributor: fullname: S Gotoh – volume: 7 year: 2017 ident: 53101_CR26 publication-title: Sci Rep doi: 10.1038/srep46751 contributor: fullname: PO Oladimeji – volume: 18 start-page: 325 year: 2008 ident: 53101_CR12 publication-title: Pharmacogenet. Genomics doi: 10.1097/FPC.0b013e3282f706e0 contributor: fullname: A Roth – volume: 62 start-page: 1238 year: 2010 ident: 53101_CR19 publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2010.08.006 contributor: fullname: AH Tolson – volume: 1859 start-page: 1072 year: 2016 ident: 53101_CR3 publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagrm.2016.03.012 contributor: fullname: J Hakkola – volume: 31 start-page: 1296 year: 2003 ident: 53101_CR23 publication-title: Drug Metab. Dispos. doi: 10.1124/dmd.31.11.1296 contributor: fullname: S Teng – volume: 10 start-page: 982 year: 2018 ident: 53101_CR24 publication-title: Nutrients doi: 10.3390/nu10080982 contributor: fullname: H Sultana – volume: 93 start-page: 556 year: 2013 ident: 53101_CR8 publication-title: Clin. Pharmacol. Ther. doi: 10.1038/clpt.2013.48 contributor: fullname: J Rysä – volume: 62 start-page: 1876 year: 2013 ident: 53101_CR10 publication-title: Diabetes doi: 10.2337/db12-1039 contributor: fullname: J He – volume: 45 start-page: 79 year: 2013 ident: 53101_CR1 publication-title: Drug Metab. Rev. doi: 10.3109/03602532.2012.740049 contributor: fullname: BD Wallace – volume: 407 start-page: 373 year: 2007 ident: 53101_CR5 publication-title: Biochem. J. doi: 10.1042/BJ20070481 contributor: fullname: S Kodama – volume: 1859 start-page: 1112 year: 2016 ident: 53101_CR17 publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagrm.2016.02.015 contributor: fullname: C Zhou – volume: 29 start-page: 1467 year: 2001 ident: 53101_CR20 publication-title: Drug Metab. Dispos. contributor: fullname: J Staudinger – volume: 24 start-page: 7931 year: 2004 ident: 53101_CR6 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.18.7931-7940.2004 contributor: fullname: S Kodama – volume: 152 start-page: 1679 year: 2017 ident: 53101_CR25 publication-title: Gastroenterology doi: 10.1053/j.gastro.2017.01.055 contributor: fullname: O Chávez-Talavera – volume: 98 start-page: 3369 year: 2001 ident: 53101_CR22 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.051551698 contributor: fullname: JL Staudinger – volume: 123 start-page: 1761 year: 2010 ident: 53101_CR18 publication-title: J. Cell. Sci. doi: 10.1242/jcs.062638 contributor: fullname: Y Ben-Ari – volume: 1859 start-page: 1155 year: 2016 ident: 53101_CR14 publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagrm.2016.01.006 contributor: fullname: D Pasquel – volume: 1 start-page: 3 year: 2017 ident: 53101_CR21 publication-title: Liver Res doi: 10.1016/j.livres.2017.05.001 contributor: fullname: JYL Chiang – volume: 153 start-page: 1 year: 2000 ident: 53101_CR2 publication-title: Toxicology doi: 10.1016/S0300-483X(00)00300-0 contributor: fullname: JT Moore – volume: 319 start-page: 693 year: 2006 ident: 53101_CR27 publication-title: J. Pharmacol. Exp. Ther. doi: 10.1124/jpet.106.107573 contributor: fullname: M Itoh – volume: 93 start-page: 119 year: 2018 ident: 53101_CR4 publication-title: Mol. Pharmacol. doi: 10.1124/mol.117.110155 contributor: fullname: PO Oladimeji – volume: 406 start-page: 371 year: 2011 ident: 53101_CR13 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2011.02.048 contributor: fullname: A Biswas |
SSID | ssj0000529419 |
Score | 2.4154599 |
Snippet | Pregnane X receptor (PXR) regulates glucose and lipid metabolism, but little is known of the nutritional regulation of PXR function. We investigated the genome... Abstract Pregnane X receptor (PXR) regulates glucose and lipid metabolism, but little is known of the nutritional regulation of PXR function. We investigated... |
SourceID | pubmedcentral proquest crossref pubmed springer |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 16728 |
SubjectTerms | 38/39 38/61 38/77 631/337/2019 631/443/319/1557 64/60 692/4020/4021/288/2032 82/58 Animals Bile Bile Acids and Salts - metabolism Cells, Cultured Cholesterol - metabolism DNA microarrays Energy balance Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Gene regulation Genomes Glucagon Glucose Glucose - pharmacology Glucose metabolism Hepatocytes Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism Homeostasis Humanities and Social Sciences Insulin Lipid metabolism Mice Mice, Inbred C57BL Mice, Knockout multidisciplinary Nutrition Nutritional Status Pregnane X Receptor - physiology Pregnenolone Science Science (multidisciplinary) Sweetening Agents - pharmacology Transcriptome - drug effects |
SummonAdditionalLinks | – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED90Q_BF_LY6pQ--adjaJl37JCqbQ3CIONhbWfOhe1hb1-7B_95L2m7MoW-BhCTcXe5-l0vuAK6FRDvAhSJo6xVB7cdIoJRLhEfjECUs8EyxiZehPxjR5zEbVxduefWsstaJRlGLlOs78jbiELR11HXoXfZFdNUoHV2tSmhsQxM7dJi2-dAbvr4tb1l0HIs6YfVbBpdu52ix9K8yJyQofuhLh-sWaQNmbr6W_BUyNZaovw97FYS070ueH8CWTA5hpywq-X0ET8M6wT4O0v-FFrk9S8VUoU9sZ3P5kUwSaY9tVHUyQ48bG6YcvRR2oQ2XUSPpTB7DqN97fxyQqlwC4bRLC4LIxGc6OQ1zgq7isSu451EVTya-0CWmQ6ZznQcO1yleHIkn1-UydOIJQizOuPROoJGkiTwDWyCOVB5D1nU4VT7OpYKO1K6Hkm6smAU3NcmirMyKEZlothdEJYEjJHBkCByFFrRqqkbVCcmjFT8tOC0JvJwKMQ12hx0LumukXw7QObHXe5Lpp8mN7SP8QJ1iwW3NpNWSf-_w_P8dXsCuqwVGv_7zWtAo5gt5iVikiK8qgfsBHJrctQ priority: 102 providerName: ProQuest – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3NS8MwFH_MieBF_LY6pQdvGl3z0TUHERHnELaTg93KmiY6cN3cOnD_vS_9mMzNg7dC0rT88pL3eyTv9wAuY41-QMWGoK83BHc_QQJjKIkZjyRaWMCyYhPtjt_q8pee6FWgLHdUADhdG9rZelLdycfN1-f8Hhf8XZ4yHtxO0QnZRDFPErQoDI_lBmxSzri1-HZB93Otbyq5J4vcmfWvLvunFdK5enfy1wFq5peau7BTEEr3IbeAPajoZB-28hKT8wN47pRy-9jJZg_Npu5wFA8MRsjueKLfkn6i3Z6LG58eY_yND1lxeh27qXVj2aYyGupD6DafXh9bpCieQBRv8JQgT_GFlaoRXtAwKqKxYoybqN_3Y1twWgqrfB54ygq-eBrXMVVaelEfCZcSSrMjqCajRJ-AGyOrNEzgRNYVNz6OZYK6toGI0TQywoGrErJwnGtkhNnZNgvCHOAQAQ4zgEPpQK1ENSynO0SWiUyGU487cJwDvBgKGQ42y7oDjSXoFx2sQvZySzJ4z5SyfSQjuMM4cF1O0s8n__7D0_91P4Ntag3I3g1kNaimk5k-R6aSRheZ-X0Db-bi7Q priority: 102 providerName: Scholars Portal – databaseName: SpringerOpen dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV07T8MwED5BERIL4k2goAxsEBHHdhqPqKJUSHSiUrco8QM6kFZtOvDvOTtJUSgMbJHsPHQ-332X830HcKM0-gGpTIC-3gRo_XiQGBMFirJcoIYl1DWbeBnFwzF7nvBJTZNja2Fa-Xua3C_RwdgiMCIC1BYMfcU27HASh1aD-3F__T_FZqwYEXVdzO-3tn3PBqDcPBf5IznqfM7gAPZrsOg_VKt7CFu6OILdqn3k5zE8jRoqfZxkK4NWS_9jpqYGo19_vtBvRVZof-KjUdNzjK3xwjWe18ovrYtyBmP2oU9gPHh87Q-DujFCIFmPlQFikJhbGhpOkp6ReaQkpczkWRYr20xacMtqnhBpyVyIxj0aSS1IniGYklxqegqdYlboc_AVIkZDOS5SKJmJ8VkmCbUNMoyOcsM9uG1Els4r_ovU5a1pklYCTlHAqRNwKjzoNlJN672wTBFBIkphEWEenFUCXj8K0QsOi9CDXkv06wmW_bo9UkzfHQt2jEADrYcHd80ifb_y7y-8-N_0S9iLrALZc3-0C51ysdJXiELK_Nqp3xcsddRi priority: 102 providerName: Springer Nature |
Title | Nutritional status modifies pregnane X receptor regulated transcriptome |
URI | https://link.springer.com/article/10.1038/s41598-019-53101-9 https://www.ncbi.nlm.nih.gov/pubmed/31723190 https://www.proquest.com/docview/2314314214 https://pubmed.ncbi.nlm.nih.gov/PMC6853963 |
Volume | 9 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dS8MwED-2ieCL-G39GH3wTbutTdKPRy2bQ9gY4mBvZU0THbiu7OPB_95L2s7N4YsvpaUhCb9ccnfk7ncAd4lAPcATaaGulxaefszypXSshNA4QAnziS420eu73SF9GbFRBViZC6OD9nk8aaSf00Y6-dCxldmUN8s4seagF7qoY1BwmlWoeoRsuOg5obcTUDsoEmRwtOYClZRKJLMDCyUO3WdFFYp6E00bdRRv6qMdI3M3VvLXhanWQ50jOCwMSPMxn-gxVER6Avt5ScmvU3jul_T62EhlC60W5nSWTCR6xGY2F-_pOBXmyMSDTmTob-OLLkYvEnOp1JY-RGZTcQbDTvst7FpFsQSLU48uLbRLXKaoaZjte5LHTsIJoTIej91EFZgOmGI6922uCF5sgfvW4SKw4zEaWJxxQc6hls5ScQlmglakJAwXrsWpdLEv6beEcjykcGLJDLgvIYuynBMj0nfZxI9yrCPEOtJYR4EBNyWqUbE_FhFCj5YLdWxqwEUO8LqrcmUM8LagXzdQjNjbf1BQNDN2IRgGPJSL9DPk3zO8-vdA13DgKLFSYYHkBmrL-UrcopGyjOsomiOvDntP7f7gFb9CN6xrhx-fPerXtdB-A_mP6aM |
link.rule.ids | 230,315,733,786,790,870,891,12083,21416,24346,27955,27956,31752,33777,41153,42222,43343,43838,51609,53825,53827,74100,74657 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT8MwDLZgE4IL4k1hQA_cINrapl17QoA2BmwVQpu0W7TmATusK3sc-Pc4fWwaE9wqpUoi27G_xMlngGshMQ5woQjGekXQ-7nEV8omwqFRgBbmO2mxiU7otXr0pe_28wO3aX6tsvCJqaMWY67PyKuIQzDWUduid8kX0VWjdHY1L6GxCWVNuemXoPzQCN_eF6csOo9FrSB_LYNDV6cYsfSrMisgaH64lw5WI9IazFy_LfkrZZpGouYe7OYQ0rzPdL4PGzI-gK2sqOT3ITyFBcE-_qTfC82n5mgshgr3xGYykR_xIJZm30RXJxPcceNHWo5eCnOmA1fqRsYjeQS9ZqP72CJ5uQTCaZ3OCCITz9XkNK7l1xWPbMEdh6poMPCELjEduJrr3Le4pnixJK5cm8vAigYIsbjLpXMMpXgcy1MwBeJI5biouhqnysO-lF-TeuuhpB0p14CbQmQsyVgxWJrNdnyWCZihgFkqYBYYUCmkyvIVMmVLfRpwkgl40RViGmwOagbUV0S_-EFzYq-2xMPPlBvbQ_iBPsWA20JJyyH_nuHZ_zO8gu1Wt9Nm7efw9Rx2bG08-iagU4HSbDKXF4hLZtFlbnw_sz7fqw |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT8MwDLZgCMQF8aYwoAduEG1t09cJIWCM18SBSbtFax6ww7qxdgf-PU7abhoT3ColSiPbsT_Hjg1wISTaAS4UQVuvCGo_n0RKuUR4NIlRwiLPNJt47QTtLn3q-b0y_ykr0yornWgUtRhxfUfeQByCto66Dm2oMi3i7a51Pf4iuoOUjrSW7TRWYQ2tZFO3cQh74ey-RUe0qBOX72ZwE40MbZd-X-bEBAURvep40TYtAc7lvMlfwVNjk1rbsFWCSfum4P4OrMh0F9aL9pLfe_DQqUrt4yT9cmia2cORGCj0ju3xRH6k_VTaPRuVnhyj740fpjG9FHauTZhRKKOh3Idu6_79tk3KxgmE05DmBDFK4OsyNb4ThYonruCeR1XS7wdCN5uOfV31PHK4LvbiSDzDLpexk_QRbHGfS-8AaukolUdgC0SUyvORiU1OVYBrqagptROipJso34LLimRsXNTHYCau7UWsIDBDAjNDYBZbUK-oysqzkrE5Zy04LAg8WwrRDQ7HTQvCBdLPJujq2Isj6eDTVMkOEIigdrHgqmLS_Jd_7_D4_x2ewwZKHXt57DyfwKarZUenBHp1qOWTqTxFgJInZ0byfgAm7-Jo |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Nutritional+status+modifies+pregnane+X+receptor+regulated+transcriptome&rft.jtitle=Scientific+reports&rft.au=Hassani-Nezhad-Gashti%2C+Fatemeh&rft.au=Kummu%2C+Outi&rft.au=Karpale%2C+Mikko&rft.au=Rys%C3%A4%2C+Jaana&rft.date=2019-11-13&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2045-2322&rft.volume=9&rft.issue=1&rft_id=info:doi/10.1038%2Fs41598-019-53101-9&rft.externalDocID=10_1038_s41598_019_53101_9 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |