Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy

• Published in: Science translational medicine Vol. 6; no. 226; p. 226ra32
• Main Authors: Zamarin, Dmitriy, Holmgaard, Rikke B, Subudhi, Sumit K, Park, Joon Seok, Mansour, Mena, Palese, Peter, Merghoub, Taha, Wolchok, Jedd D, Allison, James P
• Format: Journal Article
• Language: English
• Published: United States 05.03.2014
• Subjects: Animals; CD4-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - cytology; CTLA-4 Antigen - metabolism; Immune System; Immunotherapy - methods; Inflammation; Interferon Type I - metabolism; Killer Cells, Natural - cytology; Lymphocytes - cytology; Melanoma, Experimental; Mice; Neoplasm Transplantation; Newcastle disease virus; Oncolytic Virotherapy - methods; Oncolytic Viruses

Preexisting lymphocytic infiltration of tumors is associated with superior prognostic outcomes in a variety of cancers. Recent studies also suggest that lymphocytic responses may identify patients more likely to benefit from therapies targeting immune checkpoints, suggesting that therapeutic efficac...